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Protein Ontology report - mitotic spindle assembly checkpoint protein MAD2A
PR:000010038 - http://purl.obolibrary.org/obo/PR_000010038
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010038   
  PRO namemitotic spindle assembly checkpoint protein MAD2A 
  Synonyms
PRO-Short-label: EXACT:MAD2L1
Gene-based: RELATED:MAD2 | Mad2a
Other: EXACT:MAD2-like protein 1 | mitotic arrest deficient 2-like protein 1
  Definition"A protein that is a translation product of the human MAD2L1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 8                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000010038

mitotic spindle assembly checkpoint protein MAD2A

MAD2L1


"A protein that is a translation product of the human MAD2L1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O14417

mitotic spindle checkpoint component mad2 (Schizosaccharomyces pombe 972h-)

Spom972h-MAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O14417, PRO:KER]


Yes
organism-gene



PR:P40958

mitotic spindle checkpoint component MAD2 (yeast)

yMAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of yeast." [OMA:P40958, PMID:15249665, PMID:15514023, PMID:17504936, PRO:KER]

Yes

organism-gene



PR:P79935

mitotic spindle assembly checkpoint protein MAD2A (frog)

frog-MAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of frog." [PRO:KER]


Yes
organism-gene



PR:Q13257

mitotic spindle assembly checkpoint protein MAD2A (human)

hMAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human." [PMID:12719470, PMID:15525512, PMID:15592459, PMID:20624902, PRO:KER]

Yes

Yes
organism-sequence



PR:Q13257-1

mitotic spindle assembly checkpoint protein MAD2A isoform 1 (human)

hMAD2L1/iso:1


"A mitotic spindle assembly checkpoint protein MAD2A isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q13257-2

mitotic spindle assembly checkpoint protein MAD2A isoform h2 (human)

hMAD2L1/iso:h2


"A mitotic spindle assembly checkpoint protein MAD2A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13257-2." [PRO:DNx, UniProtKB:Q13257]


organism-modification



PR:000042259

mitotic spindle assembly checkpoint protein MAD2A, initiator methionine removed form (human)

hMAD2L1/InitMet-


"A mitotic spindle assembly checkpoint protein MAD2A (human) that has had the initiator methionine removed. Example: UniProtKB:Q13257-1, 2-205." [PRO:DAN]


Yes
organism-modification



PR:000072513

mitotic spindle assembly checkpoint protein MAD2A deaminated 1 (human)

hMAD2L1/Deam:1


"A mitotic spindle assembly checkpoint protein MAD2A (human) that has been deaminated on the residue at the position equivalent to Gln-71 of the amino acid sequence represented by UniProtKB:Q13257-1. Example: UniProtKB:Q13257-1, Gln-71, MOD:00685." [IEDB_epitope:1346551, PRO:DNx]


organism-modification



PR:000079488

mitotic spindle assembly checkpoint protein MAD2A hydroxylated 1 (human)

hMAD2L1/Hy:1


"A mitotic spindle assembly checkpoint protein MAD2A (human) that has been hydroxylated on the residue at the position equivalent to Trp-75 of the amino acid sequence represented by UniProtKB:Q13257-1. Example: UniProtKB:Q13257-1, Trp-75, MOD:01622." [IEDB_epitope:1327277, PRO:DNx]


organism-modification



PR:000079874

mitotic spindle assembly checkpoint protein MAD2A deaminated 2 (human)

hMAD2L1/Deam:2


"A mitotic spindle assembly checkpoint protein MAD2A (human) that has been deaminated on the residue at the position equivalent to Asn-66 of the amino acid sequence represented by UniProtKB:Q13257-1. Example: UniProtKB:Q13257-1, Asn-66, MOD:00684." [IEDB_epitope:1802898, PRO:DNx]


organism-modification



PR:000081542

mitotic spindle assembly checkpoint protein MAD2A acetylated 1 (human)

hMAD2L1/Ac:1


"A mitotic spindle assembly checkpoint protein MAD2A (human) that has been acetylated on the residue at the position equivalent to Lys-48 of the amino acid sequence represented by UniProtKB:Q13257-1. Example: UniProtKB:Q13257-1, Lys-48, MOD:00723." [IEDB_epitope:1831811, PRO:DNx]


organism-modification



PR:000084143

mitotic spindle assembly checkpoint protein MAD2A hydroxylated 2 (human)

hMAD2L1/Hy:2


"A mitotic spindle assembly checkpoint protein MAD2A (human) that has been hydroxylated on the residue at the position equivalent to Lys-73 of the amino acid sequence represented by UniProtKB:Q13257-1. Example: UniProtKB:Q13257-1, Lys-73, MOD:00681." [IEDB_epitope:1327276, PRO:DNx]


organism-gene



PR:Q556Y9

mitotic spindle assembly checkpoint protein MAD2A (Dictyostelium discoideum)

Dicty-MAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of Dictyostelium discoideum." [OMA:Q556Y9, PRO:DNx]


organism-gene



PR:Q59VQ3

spindle assembly checkpoint component MAD2 (Candida albicans SC5314)

Calb-MAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of Candida albicans SC5314." [OMA:Q59VQ3, PRO:DNx]


organism-gene



PR:Q9LU93

mitotic spindle checkpoint protein MAD2 (Arabidopsis thaliana)

At-MAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9LU93, PRO:DNx]


organism-sequence



PR:Q9LU93-1

mitotic spindle checkpoint protein MAD2 isoform 1 (Arabidopsis thaliana)

At-MAD2L1/iso:1


"A mitotic spindle checkpoint protein MAD2 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9LU93-1." [PRO:DNx, UniProtKB:Q9LU93]


organism-gene



PR:Q9Z1B5

mitotic spindle assembly checkpoint protein MAD2A (mouse)

mMAD2L1


"A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of mouse." [OMA:Q9Z1B5, PRO:DNx]


organism-sequence



PR:Q9Z1B5-1

mitotic spindle assembly checkpoint protein MAD2A isoform 1 (mouse)

mMAD2L1/iso:1


"A mitotic spindle assembly checkpoint protein MAD2A isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000040405

mitotic spindle assembly checkpoint protein MAD2A isoform 1

MAD2L1/iso:1


"A mitotic spindle assembly checkpoint protein MAD2A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13257-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q13257-1

mitotic spindle assembly checkpoint protein MAD2A isoform 1 (human)

hMAD2L1/iso:1


"A mitotic spindle assembly checkpoint protein MAD2A isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9Z1B5-1

mitotic spindle assembly checkpoint protein MAD2A isoform 1 (mouse)

mMAD2L1/iso:1


"A mitotic spindle assembly checkpoint protein MAD2A isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


modification



PR:000020518

mitotic spindle assembly checkpoint protein MAD2A, initiator methionine removed form

MAD2L1/InitMet-


"A mitotic spindle assembly checkpoint protein MAD2A that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000042259

mitotic spindle assembly checkpoint protein MAD2A, initiator methionine removed form (human)

hMAD2L1/InitMet-


"A mitotic spindle assembly checkpoint protein MAD2A (human) that has had the initiator methionine removed. Example: UniProtKB:Q13257-1, 2-205." [PRO:DAN]


Yes
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MAD2L1 forms found in complexes   

MAD2L1 Component
Complexes
PR:000042259 hMAD2L1/InitMet- PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:O14417 Spom972h-MAD2L1 PR:000035574 MAD2:MAD3 complex (Schizosaccharomyces pombe 972h-)
PR:P79935 frog-MAD2L1 PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
PR:Q13257 hMAD2L1 PR:000035568 MAD1:MAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P40958 yMAD2L1 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:15514023
GO:0031577 spindle checkpoint signaling PMID:17504936
PR:Q13257 hMAD2L1 acts_upstream_of_or_withinNOT GO:0051310 metaphase chromosome alignment PMID:15592459
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
enablesGO:0005515 protein binding with PR:O43684 BUB3 BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:P25054 APC BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 BioGRID:BG-718929; MINT:MINT-8289277
GO:0031625 ubiquitin protein ligase binding PMID:20624902
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_inGO:0000776 kinetochore PMID:12719470