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Protein Ontology report - protein Mdm4
PR:000010268 - http://purl.obolibrary.org/obo/PR_000010268
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010268   
  PRO nameprotein Mdm4 
  Synonyms
PRO-Short-label: EXACT:MDM4
Gene-based: RELATED:MDMX
Other: EXACT:double minute 4 protein | mdm2-like p53-binding protein | p53-binding protein Mdm4 | protein Mdmx
  Definition"A protein that is a translation product of the human MDM4 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 11                                        
         Modification1                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000010268

protein Mdm4

MDM4


"A protein that is a translation product of the human MDM4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O15151

protein Mdm4 (human)

hMDM4


"A protein Mdm4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15151]


organism-sequence



PR:O15151-1

protein Mdm4 isoform 1 (human)

hMDM4/iso:1


"A protein Mdm4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025837

protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)

hMDM4/iso:1/PhosUbiq:1


"A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:JAN]

Yes

organism-sequence



PR:O15151-2

protein Mdm4 isoform 2 (human)

hMDM4/iso:2


"A protein Mdm4 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:O15151-3

protein Mdm4 isoform h3 (human)

hMDM4/iso:h3


"A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-3." [PRO:DNx, UniProtKB:O15151]


organism-sequence



PR:O15151-4

protein Mdm4 isoform hHDMX211 (human)

hMDM4/iso:hHDMX211


"A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-4." [PRO:DNx, UniProtKB:O15151]


organism-sequence



PR:O15151-5

protein Mdm4 isoform h5 (human)

hMDM4/iso:h5


"A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-5." [PRO:DNx, UniProtKB:O15151]


organism-modification



PR:000045578

protein Mdm4 phosphorylated 1 (human)

hMDM4/Phos:1


"A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-96 of the amino acid sequence represented by UniProtKB:O15151-1. Example: UniProtKB:O15151-1, Ser-96, MOD:00046." [iPTMnet:O15151, PMID:15735705]


organism-modification



PR:000048361

protein Mdm4 phosphorylated 2 (human)

hMDM4/Phos:2


"A protein Mdm4 (human) that has been post-translationally modified to include phosphoserine at positions 342, 367 and 403 of the amino acid sequence represented by UniProtKB:O15151. UniProtKB:O15151, Ser-342/Ser-367/Ser-403, MOD:00046." [PRO:DNx, Reactome:R-HSA-349441]


organism-modification



PR:000048362

protein Mdm4 phosphorylated 3 (human)

hMDM4/Phos:3


"A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-403 of the amino acid sequence represented by UniProtKB:O15151. UniProtKB:O15151, Ser-403, MOD:00046." [PRO:DNx, Reactome:R-HSA-349461]


organism-modification



PR:000048363

protein Mdm4 ubiquitinated form (human)

hMDM4/UbiqLys+


"A protein Mdm4 (human) that includes at least one ubiquitinated lysine. UniProtKB:O15151, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782502]


organism-modification



PR:000025837

protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)

hMDM4/iso:1/PhosUbiq:1


"A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:JAN]

Yes

organism-modification



PR:000064855

protein Mdm4 phosphorylated and ubiquitinated 1 (human)

hMDM4/PhosUbiq:1


"A protein Mdm4 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-342, Ser-367, and Ser-403 of the amino acid sequence represented by UniProtKB:O15151-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:O15151-1, Ser-342/Ser-367/Ser-403, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-6804938]


organism-modification



PR:000075564

protein Mdm4 methylated 1 (human)

hMDM4/Me:1


"A protein Mdm4 (human) that has been methylated on the residue at the position equivalent to Cys-389 of the amino acid sequence represented by UniProtKB:O15151-1. Example: UniProtKB:O15151-1, Cys-389, MOD:00660." [IEDB_epitope:1029137, PRO:DNx]


organism-modification



PR:000084138

protein Mdm4 phosphorylated 4 (human)

hMDM4/Phos:4


"A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Thr-119 of the amino acid sequence represented by UniProtKB:O15151-1. Example: UniProtKB:O15151-1, Thr-119, MOD:00047." [IEDB_epitope:2149899, PRO:DNx]


organism-gene



PR:O35618

protein Mdm4 (mouse)

mMDM4


"A protein Mdm4 that is encoded in the genome of mouse." [OMA:O35618, PRO:DNx]


organism-sequence



PR:O35618-1

protein Mdm4 isoform Long (mouse)

mMDM4/iso:Long


"A protein Mdm4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35618-1." [PRO:DNx, UniProtKB:O35618]


organism-sequence



PR:O35618-2

protein Mdm4 isoform Short (mouse)

mMDM4/iso:Short


"A protein Mdm4 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q99L86

protein Mdm4 isoform 1 (mouse)

mMDM4/iso:1


"A protein Mdm4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q5XIN1

protein Mdm4 (rat)

rMDM4


"A protein Mdm4 that is encoded in the genome of rat." [OMA:Q5XIN1, PRO:DNx]


organism-sequence



PR:Q5XIN1-1

protein Mdm4 isoform 1 (rat)

rMDM4/iso:1


"A protein Mdm4 isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-gene



PR:Q7ZUW7

protein Mdm4 (zebrafish)

z-MDM4


"A protein Mdm4 that is encoded in the genome of zebrafish." [OMA:Q7ZUW7, PRO:DNx]


organism-sequence



PR:Q7ZUW7-1

protein Mdm4 isoform 1 (zebrafish)

z-MDM4/iso:1


"A protein Mdm4 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7ZUW7-1." [PRO:DNx, UniProtKB:Q7ZUW7]


organism-sequence



PR:Q7ZUW7-2

protein Mdm4 isoform 2 (zebrafish)

z-MDM4/iso:2


"A protein Mdm4 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7ZUW7-2." [PRO:DNx, UniProtKB:Q7ZUW7]


sequence



PR:000025835

protein Mdm4 isoform 1

MDM4/iso:1


"A protein Mdm4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:O15151-1

protein Mdm4 isoform 1 (human)

hMDM4/iso:1


"A protein Mdm4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025837

protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)

hMDM4/iso:1/PhosUbiq:1


"A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:JAN]

Yes

organism-sequence



PR:Q5XIN1-1

protein Mdm4 isoform 1 (rat)

rMDM4/iso:1


"A protein Mdm4 isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-sequence



PR:Q99L86

protein Mdm4 isoform 1 (mouse)

mMDM4/iso:1


"A protein Mdm4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000025836

protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1

MDM4/iso:1/PhosUbiq:1


"A protein Mdm4 isoform 1 that has been phosphorylated by Chk2, and ubiquitinated by MDM2. Example: UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:CNA, PRO:DAN]


organism-modification



PR:000025837

protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)

hMDM4/iso:1/PhosUbiq:1


"A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:JAN]

Yes

sequence



PR:000038047

protein Mdm4 isoform 2

MDM4/iso:2


"A protein Mdm4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O15151-2

protein Mdm4 isoform 2 (human)

hMDM4/iso:2


"A protein Mdm4 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:O35618-2

protein Mdm4 isoform Short (mouse)

mMDM4/iso:Short


"A protein Mdm4 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediatorPR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511560

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0071889 14-3-3 protein bindingPR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572
PR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511572

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005634 nucleusPR:000025837 hMDM4/iso:1/PhosUbiq:1 PMID:16511560