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Protein Ontology report - mediator of RNA polymerase II transcription subunit 23
PR:000010295 - http://purl.obolibrary.org/obo/PR_000010295
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010295   
  PRO namemediator of RNA polymerase II transcription subunit 23 
  Synonyms
PRO-Short-label: EXACT:MED23
Gene-based: RELATED:ARC130 | CRSP3 | DRIP130 | KIAA1216 | SUR2
Other: EXACT:activator-recruited cofactor 130 kDa component | cofactor required for Sp1 transcriptional activation subunit 3 | CRSP complex subunit 3 | mediator complex subunit 23 | protein sur-2 homolog | Sur-2 | transcriptional coactivator CRSP130 | vitamin D3 receptor-interacting protein complex 130 kDa component
  Definition"A protein that is a translation product of the human MED23 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 14                                        
         Modification0                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000010295

mediator of RNA polymerase II transcription subunit 23

MED23


"A protein that is a translation product of the human MED23 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q10669

mediator of RNA polymerase II transcription subunit 23 (worm)

MED23 (worm)


"A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of worm." [OMA:Q10669, PRO:DNx]


organism-sequence



PR:Q10669-1

mediator of RNA polymerase II transcription subunit 23 isoform a (worm)

MED23/iso:a (worm)


"A mediator of RNA polymerase II transcription subunit 23 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q10669-1." [PRO:DNx, UniProtKB:Q10669]


organism-sequence



PR:Q10669-2

mediator of RNA polymerase II transcription subunit 23 isoform b (worm)

MED23/iso:b (worm)


"A mediator of RNA polymerase II transcription subunit 23 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q10669-2." [PRO:DNx, UniProtKB:Q10669]


organism-gene



PR:Q5EB59

mediator of RNA polymerase II transcription subunit 23 (rat)

rMED23


"A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of rat." [OMA:Q5EB59, PRO:DAN]


organism-gene



PR:Q5RIW8

mediator of RNA polymerase II transcription subunit 23 (zebrafish)

z-MED23


"A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of zebrafish." [OMA:Q5RIW8, PRO:DNx]


organism-sequence



PR:Q5RIW8-1

mediator of RNA polymerase II transcription subunit 23 isoform 1 (zebrafish)

z-MED23/iso:1


"A mediator of RNA polymerase II transcription subunit 23 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RIW8-1." [PRO:DNx, UniProtKB:Q5RIW8]


organism-sequence



PR:Q5RIW8-2

mediator of RNA polymerase II transcription subunit 23 isoform 2 (zebrafish)

z-MED23/iso:2


"A mediator of RNA polymerase II transcription subunit 23 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RIW8-2." [PRO:DNx, UniProtKB:Q5RIW8]


organism-gene



PR:Q80YQ2

mediator of RNA polymerase II transcription subunit 23 (mouse)

mMED23


"A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of mouse." [OMA:Q80YQ2, PRO:DAN]


organism-sequence



PR:Q80YQ2-1

mediator of RNA polymerase II transcription subunit 23 isoform 1 (mouse)

mMED23/iso:1


"A mediator of RNA polymerase II transcription subunit 23 isoform 1 that is encoded in the genome of mouse." [PMID:14621295, PRO:HJD]

Yes

Yes
organism-sequence



PR:Q80YQ2-2

mediator of RNA polymerase II transcription subunit 23 isoform 2 (mouse)

mMED23/iso:2


"A mediator of RNA polymerase II transcription subunit 23 isoform 2 that is encoded in the genome of mouse." [PMID:11934987, PRO:HJD]


organism-sequence



PR:Q80YQ2-3

mediator of RNA polymerase II transcription subunit 23 isoform m3 (mouse)

mMED23/iso:m3


"A mediator of RNA polymerase II transcription subunit 23 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YQ2-3." [PRO:DAN, UniProtKB:Q80YQ2]


organism-gene



PR:Q9ULK4

mediator of RNA polymerase II transcription subunit 23 (human)

hMED23


"A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q5JWT2

mediator of RNA polymerase II transcription subunit 23 isoform 2 (human)

hMED23/iso:2


"A mediator of RNA polymerase II transcription subunit 23 isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q9ULK4-1

mediator of RNA polymerase II transcription subunit 23 isoform 1 (human)

hMED23/iso:1


"A mediator of RNA polymerase II transcription subunit 23 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q9ULK4-2

mediator of RNA polymerase II transcription subunit 23 isoform h2 (human)

hMED23/iso:h2


"A mediator of RNA polymerase II transcription subunit 23 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ULK4-2." [PRO:DNx, UniProtKB:Q9ULK4]


organism-sequence



PR:Q9ULK4-3

mediator of RNA polymerase II transcription subunit 23 isoform h3 (human)

hMED23/iso:h3


"A mediator of RNA polymerase II transcription subunit 23 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ULK4-3." [PRO:DNx, UniProtKB:Q9ULK4]


organism-sequence



PR:Q9ULK4-4

mediator of RNA polymerase II transcription subunit 23 isoform h4 (human)

hMED23/iso:h4


"A mediator of RNA polymerase II transcription subunit 23 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ULK4-4." [PRO:DNx, UniProtKB:Q9ULK4]


organism-sequence



PR:Q9ULK4-5

mediator of RNA polymerase II transcription subunit 23 isoform h5 (human)

hMED23/iso:h5


"A mediator of RNA polymerase II transcription subunit 23 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ULK4-5." [PRO:DNx, UniProtKB:Q9ULK4]


organism-sequence



PR:Q9ULK4-6

mediator of RNA polymerase II transcription subunit 23 isoform h6 (human)

hMED23/iso:h6


"A mediator of RNA polymerase II transcription subunit 23 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ULK4-6." [PRO:DNx, UniProtKB:Q9ULK4]


organism-modification



PR:000073631

mediator of RNA polymerase II transcription subunit 23 deaminated 1 (human)

hMED23/Deam:1


"A mediator of RNA polymerase II transcription subunit 23 (human) that has been deaminated on the residue at the position equivalent to Gln-1223 of the amino acid sequence represented by UniProtKB:Q9ULK4-1. Example: UniProtKB:Q9ULK4-1, Gln-1223, MOD:00685." [IEDB_epitope:1975765, PRO:DNx]


organism-modification



PR:000078930

mediator of RNA polymerase II transcription subunit 23 cysteinylated 1 (human)

hMED23/Cyst:1


"A mediator of RNA polymerase II transcription subunit 23 (human) that has been cysteinylated on the residue at the position equivalent to Cys-487 of the amino acid sequence represented by UniProtKB:Q9ULK4-1. Example: UniProtKB:Q9ULK4-1, Cys-487, MOD:00765." [IEDB_epitope:1315181, PRO:DNx]


organism-modification



PR:000080500

mediator of RNA polymerase II transcription subunit 23 deaminated 2 (human)

hMED23/Deam:2


"A mediator of RNA polymerase II transcription subunit 23 (human) that has been deaminated on the residue at the position equivalent to Asn-746 of the amino acid sequence represented by UniProtKB:Q9ULK4-1. Example: UniProtKB:Q9ULK4-1, Asn-746, MOD:00684." [IEDB_epitope:1990819, PRO:DNx]


organism-modification



PR:000084430

mediator of RNA polymerase II transcription subunit 23 methylated 1 (human)

hMED23/Me:1


"A mediator of RNA polymerase II transcription subunit 23 (human) that has been methylated on the residue at the position equivalent to Cys-1295 of the amino acid sequence represented by UniProtKB:Q9ULK4-1. Example: UniProtKB:Q9ULK4-1, Cys-1295, MOD:00660." [IEDB_epitope:1061854, PRO:DNx]


organism-modification



PR:000084730

mediator of RNA polymerase II transcription subunit 23 deaminated 3 (human)

hMED23/Deam:3


"A mediator of RNA polymerase II transcription subunit 23 (human) that has been deaminated on the residue at the position equivalent to Gln-587 of the amino acid sequence represented by UniProtKB:Q9ULK4-1. Example: UniProtKB:Q9ULK4-1, Gln-587, MOD:00685." [IEDB_epitope:1340918, PRO:DNx]


organism-gene



PR:Q9W1X7

mediator of RNA polymerase II transcription subunit 23 (fruit fly)

fly-MED23


"A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of fruit fly." [OMA:Q9W1X7, PRO:DNx]


sequence



PR:000028916

mediator of RNA polymerase II transcription subunit 23 isoform 1

MED23/iso:1


"A mediator of RNA polymerase II transcription subunit 23 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YQ2-1 or a 1:1 ortholog thereof." [PMID:14621295, PRO:HJD]


organism-sequence



PR:Q80YQ2-1

mediator of RNA polymerase II transcription subunit 23 isoform 1 (mouse)

mMED23/iso:1


"A mediator of RNA polymerase II transcription subunit 23 isoform 1 that is encoded in the genome of mouse." [PMID:14621295, PRO:HJD]

Yes

Yes
organism-sequence



PR:Q9ULK4-1

mediator of RNA polymerase II transcription subunit 23 isoform 1 (human)

hMED23/iso:1


"A mediator of RNA polymerase II transcription subunit 23 isoform 1 that is encoded in the genome of human." [PRO:HJD]


sequence



PR:000028918

mediator of RNA polymerase II transcription subunit 23 isoform 2

MED23/iso:2


"A mediator of RNA polymerase II transcription subunit 23 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YQ2-2 or a 1:1 ortholog thereof." [PMID:11934987, PRO:HJD]


organism-sequence



PR:Q5JWT2

mediator of RNA polymerase II transcription subunit 23 isoform 2 (human)

hMED23/iso:2


"A mediator of RNA polymerase II transcription subunit 23 isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q80YQ2-2

mediator of RNA polymerase II transcription subunit 23 isoform 2 (mouse)

mMED23/iso:2


"A mediator of RNA polymerase II transcription subunit 23 isoform 2 that is encoded in the genome of mouse." [PMID:11934987, PRO:HJD]


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MED23 forms found in complexes   

MED23 Component
Complexes
PR:Q80YQ2ZDASHZ1 mMED23/iso:1 PR:000028902 mediator complex, MED26-containing (mouse)
PR:000028957 mediator complex, CDK8-containing (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q80YQ2-1 mMED23/iso:1 located_inGO:0016592 mediator complex MGI_ref:4462751; PMID:20508642