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Protein Ontology report - myocyte-specific enhancer factor 2C
PR:000010311 - http://purl.obolibrary.org/obo/PR_000010311
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010311   
  PRO namemyocyte-specific enhancer factor 2C 
  Synonyms
PRO-Short-label: EXACT:MEF2C
Other: EXACT:myocyte enhancer factor 2C
  Definition"A protein that is a translation product of the human MEF2C gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 16                                        
         Modification2                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000010311

myocyte-specific enhancer factor 2C

MEF2C


"A protein that is a translation product of the human MEF2C gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:A0A096MJY4

myocyte-specific enhancer factor 2C (rat)

rMEF2C


"A myocyte-specific enhancer factor 2C that is encoded in the genome of rat." [OMA:A0A096MJY4, PRO:DNx]


organism-gene



PR:P40791

myocyte-specific enhancer factor 2 (fruit fly)

fly-MEF2C


"A myocyte-specific enhancer factor 2C that is encoded in the genome of fruit fly." [PRO:DNx]


organism-sequence



PR:P40791-1

myocyte-specific enhancer factor 2 isoform D (fruit fly)

fly-MEF2C/iso:D


"A myocyte-specific enhancer factor 2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40791-1." [PRO:DNx, UniProtKB:P40791]


organism-sequence



PR:P40791-2

myocyte-specific enhancer factor 2 isoform A (fruit fly)

fly-MEF2C/iso:A


"A myocyte-specific enhancer factor 2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40791-2." [PRO:DNx, UniProtKB:P40791]


organism-sequence



PR:P40791-3

myocyte-specific enhancer factor 2 isoform B (fruit fly)

fly-MEF2C/iso:B


"A myocyte-specific enhancer factor 2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40791-3." [PRO:DNx, UniProtKB:P40791]


organism-sequence



PR:P40791-4

myocyte-specific enhancer factor 2 isoform C (fruit fly)

fly-MEF2C/iso:C


"A myocyte-specific enhancer factor 2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40791-4." [PRO:DNx, UniProtKB:P40791]


organism-sequence



PR:P40791-6

myocyte-specific enhancer factor 2 isoform F (fruit fly)

fly-MEF2C/iso:F


"A myocyte-specific enhancer factor 2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40791-6." [PRO:DNx, UniProtKB:P40791]


organism-gene



PR:Q06413

myocyte-specific enhancer factor 2C (human)

hMEF2C


"A myocyte-specific enhancer factor 2C that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q06413]


organism-sequence



PR:Q06413-1

myocyte-specific enhancer factor 2C isoform 1 (human)

hMEF2C/iso:1


"A myocyte-specific enhancer factor 2C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q06413-2

myocyte-specific enhancer factor 2C isoform 2 (human)

hMEF2C/iso:2


"A myocyte-specific enhancer factor 2C isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q06413-3

myocyte-specific enhancer factor 2C isoform h3 (human)

hMEF2C/iso:h3


"A myocyte-specific enhancer factor 2C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06413-3." [PRO:DNx, UniProtKB:Q06413]


organism-sequence



PR:Q06413-4

myocyte-specific enhancer factor 2C isoform h4 (human)

hMEF2C/iso:h4


"A myocyte-specific enhancer factor 2C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06413-4." [PRO:DNx, UniProtKB:Q06413]


organism-sequence



PR:Q06413-5

myocyte-specific enhancer factor 2C isoform h5 (human)

hMEF2C/iso:h5


"A myocyte-specific enhancer factor 2C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06413-5." [PRO:DNx, UniProtKB:Q06413]


organism-sequence



PR:Q06413-6

myocyte-specific enhancer factor 2C isoform h6 (human)

hMEF2C/iso:h6


"A myocyte-specific enhancer factor 2C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06413-6." [PRO:DNx, UniProtKB:Q06413]


organism-modification



PR:000048367

myocyte-specific enhancer factor 2C phosphorylated 1 (human)

hMEF2C/Phos:1


"A myocyte-specific enhancer factor 2C (human) that has been phosphorylated on the residue at the position equivalent to Ser-396 of the amino acid sequence represented by UniProtKB:Q06413. UniProtKB:Q06413, Ser-396, MOD:00046." [PRO:DNx, Reactome:R-HSA-199942]


organism-modification



PR:000048368

myocyte-specific enhancer factor 2C phosphorylated 2 (human)

hMEF2C/Phos:2


"A myocyte-specific enhancer factor 2C (human) that has been post-translationally modified to include phosphothreonine at positions 293 and 300, and phosphoserine at position 419 of the amino acid sequence represented by UniProtKB:Q06413. UniProtKB:Q06413, Thr-293/Thr-300, MOD:00047|Ser-419, MOD:00046." [PMID:9069290, PRO:DAN]


organism-modification



PR:000061052

myocyte-specific enhancer factor 2C phosphorylated 3 (human)

hMEF2C/Phos:3


"A myocyte-specific enhancer factor 2C (human) that has been phosphorylated on the residues at the positions equivalent to Thr-293, Thr-300, and Ser-387 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Thr-293/Thr-300, MOD:00047|Ser-387, MOD:00046." [PRO:DNx, Reactome:R-HSA-448838]


organism-modification



PR:000065606

myocyte-specific enhancer factor 2C cysteinylated 1 (human)

hMEF2C/Cyst:1


"A myocyte-specific enhancer factor 2C (human) that has been cysteinylated on the residue at the position equivalent to Cys-427 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Cys-427, MOD:00765." [IEDB_epitope:1587580, PRO:DNx]


organism-modification



PR:000073322

myocyte-specific enhancer factor 2C O-glycosylated 1 (human)

hMEF2C/OGlyco:1


"A myocyte-specific enhancer factor 2C (human) that has been O-glycosylated on the residue at the position equivalent to Ser-150 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Ser-150, MOD:00002." [IEDB_epitope:1074935, PRO:DNx]


organism-modification



PR:000075060

myocyte-specific enhancer factor 2C phosphorylated 4 (human)

hMEF2C/Phos:4


"A myocyte-specific enhancer factor 2C (human) that has been phosphorylated on the residue at the position equivalent to Ser-445 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Ser-445, MOD:00046." [IEDB_epitope:610111, PRO:DNx]


organism-modification



PR:000076759

myocyte-specific enhancer factor 2C methylated 1 (human)

hMEF2C/Me:1


"A myocyte-specific enhancer factor 2C (human) that has been methylated on the residue at the position equivalent to Cys-134 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Cys-134, MOD:00660." [IEDB_epitope:1042536, PRO:DNx]


organism-modification



PR:000077426

myocyte-specific enhancer factor 2C cysteinylated 2 (human)

hMEF2C/Cyst:2


"A myocyte-specific enhancer factor 2C (human) that has been cysteinylated on the residue at the position equivalent to Cys-134 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Cys-134, MOD:00765." [IEDB_epitope:1003880, PRO:DNx]


organism-modification



PR:000082777

myocyte-specific enhancer factor 2C O-glycosylated 2 (human)

hMEF2C/OGlyco:2


"A myocyte-specific enhancer factor 2C (human) that has been O-glycosylated on the residue at the position equivalent to Ser-151 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Ser-151, MOD:00002." [IEDB_epitope:438286, PRO:DNx]


organism-modification



PR:000083981

myocyte-specific enhancer factor 2C phosphorylated 5 (human)

hMEF2C/Phos:5


"A myocyte-specific enhancer factor 2C (human) that has been phosphorylated on the residue at the position equivalent to Ser-183 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Ser-183, MOD:00046." [IEDB_epitope:847668, PRO:DNx]


organism-modification



PR:000084185

myocyte-specific enhancer factor 2C phosphorylated 6 (human)

hMEF2C/Phos:6


"A myocyte-specific enhancer factor 2C (human) that has been phosphorylated on the residue at the position equivalent to Thr-293 of the amino acid sequence represented by UniProtKB:Q06413-1. Example: UniProtKB:Q06413-1, Thr-293, MOD:00047." [IEDB_epitope:1370530, PRO:DNx]


organism-gene



PR:Q8CFN5

myocyte-specific enhancer factor 2C (mouse)

mMEF2C


"A myocyte-specific enhancer factor 2C that is encoded in the genome of mouse." [OMA:Q8CFN5, PRO:DNx]


organism-sequence



PR:Q8CFN5-1

myocyte-specific enhancer factor 2C isoform 1 (mouse)

mMEF2C/iso:1


"A myocyte-specific enhancer factor 2C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q8CFN5-2

myocyte-specific enhancer factor 2C isoform 2 (mouse)

mMEF2C/iso:2


"A myocyte-specific enhancer factor 2C isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000027930

myocyte-specific enhancer factor 2C isoform 2 acetylated 1 (mouse)

mMEF2C/iso:2/Ac:1


"A myocyte-specific enhancer factor 2C isoform 2 acetylated 1 in mouse. UniProtKB:Q8CFN5-2, Lys-4, MOD:00064." [PMID:18086704, PRO:CNA]

Yes

organism-modification



PR:000027940

myocyte-specific enhancer factor 2C isoform 2 unmodified form (mouse)

mMEF2C/iso:2/UnMod


"A myocyte-specific enhancer factor 2C isoform 2 unmodified form in mouse." [PRO:CNA]


organism-sequence



PR:Q8CFN5-3

myocyte-specific enhancer factor 2C isoform m3 (mouse)

mMEF2C/iso:m3


"A myocyte-specific enhancer factor 2C (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFN5-3." [PRO:DNx, UniProtKB:Q8CFN5]


organism-sequence



PR:Q8CFN5-4

myocyte-specific enhancer factor 2C isoform m4 (mouse)

mMEF2C/iso:m4


"A myocyte-specific enhancer factor 2C (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFN5-4." [PRO:DNx, UniProtKB:Q8CFN5]


organism-sequence



PR:Q8CFN5-5

myocyte-specific enhancer factor 2C isoform m5 (mouse)

mMEF2C/iso:m5


"A myocyte-specific enhancer factor 2C (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFN5-5." [PRO:DNx, UniProtKB:Q8CFN5]


sequence



PR:000027925

myocyte-specific enhancer factor 2C isoform 1

MEF2C/iso:1


"A myocyte-specific enhancer factor 2C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFN5-1 or a 1:1 ortholog thereof." [PMID:18086704, PRO:CNA]


organism-sequence



PR:Q06413-1

myocyte-specific enhancer factor 2C isoform 1 (human)

hMEF2C/iso:1


"A myocyte-specific enhancer factor 2C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8CFN5-1

myocyte-specific enhancer factor 2C isoform 1 (mouse)

mMEF2C/iso:1


"A myocyte-specific enhancer factor 2C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000027927

myocyte-specific enhancer factor 2C isoform 2

MEF2C/iso:2


"A myocyte-specific enhancer factor 2C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFN5-2 or a 1:1 ortholog thereof." [PMID:18086704, PRO:CNA]


organism-sequence



PR:Q06413-2

myocyte-specific enhancer factor 2C isoform 2 (human)

hMEF2C/iso:2


"A myocyte-specific enhancer factor 2C isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8CFN5-2

myocyte-specific enhancer factor 2C isoform 2 (mouse)

mMEF2C/iso:2


"A myocyte-specific enhancer factor 2C isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000027930

myocyte-specific enhancer factor 2C isoform 2 acetylated 1 (mouse)

mMEF2C/iso:2/Ac:1


"A myocyte-specific enhancer factor 2C isoform 2 acetylated 1 in mouse. UniProtKB:Q8CFN5-2, Lys-4, MOD:00064." [PMID:18086704, PRO:CNA]

Yes

organism-modification



PR:000027940

myocyte-specific enhancer factor 2C isoform 2 unmodified form (mouse)

mMEF2C/iso:2/UnMod


"A myocyte-specific enhancer factor 2C isoform 2 unmodified form in mouse." [PRO:CNA]


modification



PR:000027929

myocyte-specific enhancer factor 2C isoform 2 acetylated 1

MEF2C/iso:2/Ac:1


"A myocyte-specific enhancer factor 2C isoform 2 that has been acetylated in the first Lys residue of the conserved sequence KKGRIQ in the N-terminal MADS box domain (SRF-TF (Pfam:PF00319) domain). Example: UniProtKB:Q8CFN5-2, Lys-4, MOD:00064." [PMID:18086704, PRO:CNA]


organism-modification



PR:000027930

myocyte-specific enhancer factor 2C isoform 2 acetylated 1 (mouse)

mMEF2C/iso:2/Ac:1


"A myocyte-specific enhancer factor 2C isoform 2 acetylated 1 in mouse. UniProtKB:Q8CFN5-2, Lys-4, MOD:00064." [PMID:18086704, PRO:CNA]

Yes

modification



PR:000027939

myocyte-specific enhancer factor 2C isoform 2 unmodified form

MEF2C/iso:2/UnMod


"A myocyte-specific enhancer factor 2C isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]


organism-modification



PR:000027940

myocyte-specific enhancer factor 2C isoform 2 unmodified form (mouse)

mMEF2C/iso:2/UnMod


"A myocyte-specific enhancer factor 2C isoform 2 unmodified form in mouse." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027930 mMEF2C/iso:2/Ac:1
UniProtKB:Q8CFN5-2, Lys-4, MOD:00064
acts_upstream_of_or_withinGO:0035914 skeletal muscle cell differentiation PMID:18086704
enablesincreased GO:0003677 DNA binding relative to PR:000027940 MEF2C unmodified (mouse) PMID:18086704