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Protein Ontology report - 72 kDa type IV collagenase
PR:000010479 - http://purl.obolibrary.org/obo/PR_000010479
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010479   
  PRO name72 kDa type IV collagenase 
  Synonyms
PRO-Short-label: EXACT:MMP2
Gene-based: RELATED:CLG4A
Other: EXACT:72 kDa gelatinase | gelatinase A | matrix metalloproteinase-2 | MMP-2 | TBE-1
  Definition"A protein that is a translation product of the human MMP2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification1                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1629
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000010479

72 kDa type IV collagenase

MMP2


"A protein that is a translation product of the human MMP2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P08253

72 kDa type IV collagenase (human)

hMMP2


"A 72 kDa type IV collagenase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08253]


organism-sequence



PR:P08253-1

72 kDa type IV collagenase isoform 1 (human)

hMMP2/iso:1


"A 72 kDa type IV collagenase isoform 1 that is encoded in the genome of human." [PMID:14702039, PMID:2834383, PRO:CNA]


organism-sequence



PR:P08253-2

72 kDa type IV collagenase isoform 2 (human)

hMMP2/iso:2


"A 72 kDa type IV collagenase isoform 2 that is encoded in the genome of human." [PMID:14702039, PRO:CNA]


organism-sequence



PR:P08253-3

72 kDa type IV collagenase isoform h3 (human)

hMMP2/iso:h3


"A 72 kDa type IV collagenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08253-3." [PRO:DNx, UniProtKB:P08253]


organism-modification



PR:000048400

72 kDa type IV collagenase, signal peptide removed form (human)

hMMP2/SigPep-


"A 72 kDa type IV collagenase (human) that has had the signal peptide removed. UniProtKB:P08253, 30-660." [PRO:DNx, Reactome:R-HSA-1604364]


organism-modification



PR:000054441

72 kDa type IV collagenase O-glycosylated 1 (human)

hMMP2/OGlyco:1


"A 72 kDa type IV collagenase (human) that has been O-glycosylated at the residue equivalent to Thr-460 of the amino acid sequence represented by UniProtKB:P08253-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08253-1, Thr-460, MOD:00005~GNO:G29068FM." [GlyGen:P08253-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000054442

72 kDa type IV collagenase O-glycosylated 2 (human)

hMMP2/OGlyco:2


"A 72 kDa type IV collagenase (human) that has been O-glycosylated at the residue equivalent to Thr-460 of the amino acid sequence represented by UniProtKB:P08253-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08253-1, Thr-460, MOD:00005~GNO:G43417UB." [GlyGen:P08253-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P33434

72 kDa type IV collagenase (mouse)

mMMP2


"A 72 kDa type IV collagenase that is encoded in the genome of mouse." [OMA:P33434, PRO:DNx]


organism-sequence



PR:P33434-1

72 kDa type IV collagenase isoform 1 (mouse)

mMMP2/iso:1


"A 72 kDa type IV collagenase isoform 1 that is encoded in the genome of mouse." [PMID:1373140, PRO:HJD]

Yes

organism-sequence



PR:P33434-2

72 kDa type IV collagenase isoform 2 (mouse)

mMMP2/iso:2


"A 72 kDa type IV collagenase isoform 2 that is encoded in the genome of mouse." [PMID:22509276, PRO:HJD]

Yes

organism-gene



PR:P33436

72 kDa type IV collagenase (rat)

rMMP2


"A 72 kDa type IV collagenase that is encoded in the genome of rat." [OMA:P33436, PRO:DNx]


organism-gene



PR:Q90611

72 kDa type IV collagenase (chicken)

chick-MMP2


"A 72 kDa type IV collagenase that is encoded in the genome of chicken." [OMA:Q90611, PRO:DNx]


sequence



PR:000037236

72 kDa type IV collagenase isoform 1

MMP2/iso:1


"A 72 kDa type IV collagenase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33434-1 or a 1:1 ortholog thereof." [PMID:1373140, PRO:HJD]


organism-sequence



PR:P08253-1

72 kDa type IV collagenase isoform 1 (human)

hMMP2/iso:1


"A 72 kDa type IV collagenase isoform 1 that is encoded in the genome of human." [PMID:14702039, PMID:2834383, PRO:CNA]


organism-sequence



PR:P33434-1

72 kDa type IV collagenase isoform 1 (mouse)

mMMP2/iso:1


"A 72 kDa type IV collagenase isoform 1 that is encoded in the genome of mouse." [PMID:1373140, PRO:HJD]

Yes

sequence



PR:000037238

72 kDa type IV collagenase isoform 2

MMP2/iso:2


"A 72 kDa type IV collagenase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33434-2 or a 1:1 ortholog thereof. This form lacks the region that codes for the N-terminal signal peptide and part of the propeptide." [PMID:22509276, PRO:HJD]


organism-sequence



PR:P08253-2

72 kDa type IV collagenase isoform 2 (human)

hMMP2/iso:2


"A 72 kDa type IV collagenase isoform 2 that is encoded in the genome of human." [PMID:14702039, PRO:CNA]


organism-sequence



PR:P33434-2

72 kDa type IV collagenase isoform 2 (mouse)

mMMP2/iso:2


"A 72 kDa type IV collagenase isoform 2 that is encoded in the genome of mouse." [PMID:22509276, PRO:HJD]

Yes

modification



PR:000020610

72 kDa type IV collagenase proteolytic cleavage product

MMP2/ClvPrd


"A 72 kDa type IV collagenase that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P33434-1 mMMP2/iso:1 located_inGO:0005615 extracellular space MGI_ref:5435352; PMID:22509276
PR:P33434-2 mMMP2/iso:2 acts_upstream_of_or_withinGO:0045089 positive regulation of innate immune response MGI_ref:5435352; PMID:22509276
located_inGO:0005737 cytoplasm MGI_ref:5435352; PMID:22509276
GO:0005739 mitochondrion MGI_ref:5435352; PMID:22509276