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Protein Ontology report - myoblast determination protein 1
PR:000010875 - http://purl.obolibrary.org/obo/PR_000010875
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010875   
  PRO namemyoblast determination protein 1 
  Synonyms
PRO-Short-label: EXACT:MYOD1
Gene-based: RELATED:BHLHC1 | MYF3 | MYOD
Other: EXACT:bHLHc1 | class C basic helix-loop-helix protein 1 | Myf-3 | myogenic factor 3
  Definition"A protein that is a translation product of the human MYOD1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000010875

myoblast determination protein 1

MYOD1


"A protein that is a translation product of the human MYOD1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P10085

myoblast determination protein 1 (mouse)

mMYOD1


"A myoblast determination protein 1 that is encoded in the genome of mouse." [OMA:P10085, PRO:DNx]


organism-sequence



PR:P10085-1

myoblast determination protein 1 isoform 1 (mouse)

mMYOD1/iso:1


"A myoblast determination protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:PD]


organism-modification



PR:000029162

myoblast determination protein 1 phosphorylated 1 (mouse)

mMYOD1/Phos:1


"A myoblast determination protein 1 phosphorylated 1 in mouse. This phosphorylated form shows decreased transcription factor activity towards myogenin. UniProtKB:P10085, Ser-199/Ser-200, MOD:00046." [PMID:20026657, PRO:ALI]

Yes

organism-modification



PR:000029164

myoblast determination protein 1 unmodified form (mouse)

mMYOD1/UnMod


"A myoblast determination protein 1 unmodified form in mouse." [PRO:CNA]


organism-modification



PR:000029166

myoblast determination protein 1 phosphorylated 2 (mouse)

mMYOD1/Phos:2


"A myoblast determination protein 1 phosphorylated 2 in mouse. This phosphorylation occurs via activation of the cyclin B-Cdc2 complex, and represseses transcriptional activity of the protein. UniProtKB:P10085, Ser-5/Ser-200, MOD:00046." [PMID:14749395, PRO:ALI]


organism-modification



PR:000029168

myoblast determination protein 1 phosphorylated 3 (mouse)

mMYOD1/Phos:3


"A myoblast determination protein 1 phosphorylated 3 in mouse. This phosphorylation decreases DNA binding activity. UniProtKB:P10085, Thr-115, MOD:00047." [PMID:17761773, PRO:ALI]


organism-gene



PR:P15172

myoblast determination protein 1 (human)

hMYOD1


"A myoblast determination protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P15172]


organism-sequence



PR:P15172-1

myoblast determination protein 1 isoform 1 (human)

hMYOD1/iso:1


"A myoblast determination protein 1 isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028762

myoblast determination protein 1 isoform 1 acetylated 1 (human)

hMYOD1/iso:1/Ac:1


"A myoblast determination protein 1 isoform 1 acetylated 1 in human. UniProtKB:P15172-1, Lys-99/Lys-102, MOD:00064." [PMID:10944526, PRO:PD]


organism-modification



PR:000045682

myoblast determination protein 1 phosphorylated 1 (human)

hMYOD1/Phos:1


"A myoblast determination protein 1 (human) that has been phosphorylated at Ser-200. UniProtKB:P15172, Ser-200, MOD:00046." [iPTMnet:P15172, PMID:9710583]


organism-gene



PR:P16075

myoblast determination protein 1 homolog (chicken)

chick-MYOD1


"A myoblast determination protein 1 that is encoded in the genome of chicken." [OMA:P16075, PRO:DNx]


organism-gene



PR:Q02346

myoblast determination protein 1 (rat)

rMYOD1


"A myoblast determination protein 1 that is encoded in the genome of rat." [OMA:Q02346, PRO:DNx]


organism-gene



PR:Q90477

myoblast determination protein 1 homolog (zebrafish)

z-MYOD1


"A myoblast determination protein 1 that is encoded in the genome of zebrafish." [OMA:Q90477, PRO:DNx]


sequence



PR:000028759

myoblast determination protein 1 isoform 1

MYOD1/iso:1


"A myoblast determination protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15172-1 or a 1:1 ortholog thereof." [PMID:10944526, PRO:PD]


organism-sequence



PR:P10085-1

myoblast determination protein 1 isoform 1 (mouse)

mMYOD1/iso:1


"A myoblast determination protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:PD]


organism-sequence



PR:P15172-1

myoblast determination protein 1 isoform 1 (human)

hMYOD1/iso:1


"A myoblast determination protein 1 isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028762

myoblast determination protein 1 isoform 1 acetylated 1 (human)

hMYOD1/iso:1/Ac:1


"A myoblast determination protein 1 isoform 1 acetylated 1 in human. UniProtKB:P15172-1, Lys-99/Lys-102, MOD:00064." [PMID:10944526, PRO:PD]


modification



PR:000028761

myoblast determination protein 1 isoform 1 acetylated 1

MYOD1/iso:1/Ac:1


"A myoblast determination protein 1 isoform 1 that has been acetylated on Lys residues located at the boundary of the DNA binding/dimerization domain. Example: UniProtKB:P15172-1, Lys-99/Lys-102, MOD:00064." [PMID:10944526, PRO:PD]


organism-modification



PR:000028762

myoblast determination protein 1 isoform 1 acetylated 1 (human)

hMYOD1/iso:1/Ac:1


"A myoblast determination protein 1 isoform 1 acetylated 1 in human. UniProtKB:P15172-1, Lys-99/Lys-102, MOD:00064." [PMID:10944526, PRO:PD]


modification



PR:000029161

myoblast determination protein 1 phosphorylated 1

MYOD1/Phos:1


"A myoblast determination protein 1 that has been phosphorylated on either one or two of the consecutive Ser residues in the motif GDSDASSPRSNC. This phosphorylation occurs via activation of the MAPK12 (p38 gamma) dependent signaling. Example: UniProtKB:P10085, Ser-199/Ser-200, MOD:00046." [PMID:20026657, PRO:ALI]


organism-modification



PR:000029162

myoblast determination protein 1 phosphorylated 1 (mouse)

mMYOD1/Phos:1


"A myoblast determination protein 1 phosphorylated 1 in mouse. This phosphorylated form shows decreased transcription factor activity towards myogenin. UniProtKB:P10085, Ser-199/Ser-200, MOD:00046." [PMID:20026657, PRO:ALI]

Yes

modification



PR:000029163

myoblast determination protein 1 unmodified form

MYOD1/UnMod


"A myoblast determination protein 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]


organism-modification



PR:000029164

myoblast determination protein 1 unmodified form (mouse)

mMYOD1/UnMod


"A myoblast determination protein 1 unmodified form in mouse." [PRO:CNA]


modification



PR:000029165

myoblast determination protein 1 phosphorylated 2

MYOD1/Phos:2


"A myoblast determination protein 1 that has been phosphorylated on in a Ser located in the transactivation domain, and the second Ser residue of the consecutive Ser residues in the motif GDSDASSPRSNC. These Ser are in consensus CDK sites ([ST]P). Example: UniProtKB:P10085, Ser-5/Ser-200, MOD:00046." [PMID:14749395, PRO:ALI]


organism-modification



PR:000029166

myoblast determination protein 1 phosphorylated 2 (mouse)

mMYOD1/Phos:2


"A myoblast determination protein 1 phosphorylated 2 in mouse. This phosphorylation occurs via activation of the cyclin B-Cdc2 complex, and represseses transcriptional activity of the protein. UniProtKB:P10085, Ser-5/Ser-200, MOD:00046." [PMID:14749395, PRO:ALI]


modification



PR:000029167

myoblast determination protein 1 phosphorylated 3

MYOD1/Phos:3


"A myoblast determination protein 1 that has been phosphorylated on a Thr residue within the DNA-binding domain. Example: UniProtKB:P10085, Thr-115, MOD:00047." [PMID:17761773, PRO:ALI]


organism-modification



PR:000029168

myoblast determination protein 1 phosphorylated 3 (mouse)

mMYOD1/Phos:3


"A myoblast determination protein 1 phosphorylated 3 in mouse. This phosphorylation decreases DNA binding activity. UniProtKB:P10085, Thr-115, MOD:00047." [PMID:17761773, PRO:ALI]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029162 mMYOD1/Phos:1
UniProtKB:P10085, Ser-199/Ser-200, MOD:00046
enablesincreased GO:0001046 core promoter sequence-specific DNA binding relative to PR:000029164 mMYOD1/UnMod PMID:20026657
decreased GO:0003700 DNA-binding transcription factor activity relative to PR:000029164 mMYOD1/UnMod PMID:20026657