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Protein Ontology report - nuclear receptor coactivator 3
PR:000011042 - http://purl.obolibrary.org/obo/PR_000011042
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000011042   
  PRO namenuclear receptor coactivator 3 
  Synonyms
PRO-Short-label: EXACT:NCOA3
Gene-based: RELATED:AIB1 | BHLHE42 | RAC3 | TRAM1
Other: EXACT:ACTR | AIB-1 | amplified in breast cancer 1 protein | amplified in breast cancer-1 protein homolog | bHLHe42 | CBP-interacting protein | class E basic helix-loop-helix protein 42 | NCoA-3 | p/CIP | pCIP | RAC-3 | receptor-associated coactivator 3 | SRC-3 | steroid receptor coactivator protein 3 | thyroid hormone receptor activator molecule 1 | TRAM-1
  Definition"A protein that is a translation product of the human NCOA3 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification6                                                  Organism-Modification 12                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2695
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
gene


PR:000011042
nuclear receptor coactivator 3
NCOA3
"A protein that is a translation product of the human NCOA3 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:O09000
nuclear receptor coactivator 3 (mouse)
mNCOA3
"A nuclear receptor coactivator 3 that is encoded in the genome of mouse." [OMA:O09000, PRO:DNx]

organism-gene


PR:Q9Y6Q9
nuclear receptor coactivator 3 (human)
hNCOA3
"A nuclear receptor coactivator 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y6Q9]

organism-sequence


PR:Q9Y6Q9-1
nuclear receptor coactivator 3 isoform 1 (human)
hNCOA3/iso:1
"A nuclear receptor coactivator 3 isoform 1 that is encoded in the genome of human." [PRO:PD]

organism-modification


PR:000027692
nuclear receptor coactivator 3 isoform 1 phosphorylated 1 (human)
hNCOA3/iso:1/Phos:1
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6Q9-1, Ser-101/Ser-102, MOD:00046." [PMID:18922467, PMID:21577200, PRO:PD]
Yes
organism-modification


PR:000027694
nuclear receptor coactivator 3 isoform 1 phosphorylated 2 (human)
hNCOA3/iso:1/Phos:2
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6Q9-1, Ser-601, MOD:00046." [PMID:19339517, PRO:PD]
Yes
organism-modification


PR:000027696
nuclear receptor coactivator 3 isoform 1 phosphorylated 3 (human)
hNCOA3/iso:1/Phos:3
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6Q9-1, Tyr-1357, MOD:00048." [PMID:18765637, PRO:PD]
Yes
organism-modification


PR:000027698
nuclear receptor coactivator 3 isoform 1 phosphorylated 4 (human)
hNCOA3/iso:1/Phos:4
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 4 in human. UniProtKB:Q9Y6Q9-1, Ser-857, MOD:00046." [PMID:15383283, PRO:PD]

organism-modification


PR:000027885
nuclear receptor coactivator 3 isoform 1 acetylated 1 (human)
hNCOA3/iso:1/Ac:1
"A nuclear receptor coactivator 3 isoform 1 acetylated 1 in human. UniProtKB:Q9Y6Q9-1, Lys-619/Lys-620, MOD:00064." [PMID:10490106, PRO:PD]
Yes
organism-modification


PR:000027887
nuclear receptor coactivator 3 isoform 1 acetylated 2 (human)
hNCOA3/iso:1/Ac:2
"A nuclear receptor coactivator 3 isoform 1 acetylated 2 in human. UniProtKB:Q9Y6Q9-1, Lys-687, MOD:00064." [PMID:19608861, PRO:PD]

organism-sequence


PR:Q9Y6Q9-2
nuclear receptor coactivator 3 isoform h2 (human)
hNCOA3/iso:h2
"A nuclear receptor coactivator 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6Q9-2." [PRO:DNx, UniProtKB:Q9Y6Q9]

organism-sequence


PR:Q9Y6Q9-3
nuclear receptor coactivator 3 isoform h3 (human)
hNCOA3/iso:h3
"A nuclear receptor coactivator 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6Q9-3." [PRO:DNx, UniProtKB:Q9Y6Q9]

organism-sequence


PR:Q9Y6Q9-4
nuclear receptor coactivator 3 isoform h4 (human)
hNCOA3/iso:h4
"A nuclear receptor coactivator 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6Q9-4." [PRO:DNx, UniProtKB:Q9Y6Q9]

organism-sequence


PR:Q9Y6Q9-5
nuclear receptor coactivator 3 isoform h5 (human)
hNCOA3/iso:h5
"A nuclear receptor coactivator 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6Q9-5." [PRO:DNx, UniProtKB:Q9Y6Q9]

organism-modification


PR:000048530
nuclear receptor coactivator 3 phosphorylated 4 (human)
hNCOA3/Phos:4
"A nuclear receptor coactivator 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-857 of the amino acid sequence represented by UniProtKB:Q9Y6Q9. UniProtKB:Q9Y6Q9, Ser-857, MOD:00046." [PRO:DNx, Reactome:R-HSA-5687005]

organism-modification


PR:000064921
nuclear receptor coactivator 3 methylated 1 (human)
hNCOA3/Me:1
"A nuclear receptor coactivator 3 (human) that has been methylated on the residue at the position equivalent to Arg-1163 of the amino acid sequence represented by UniProtKB:Q9Y6Q9-1. Example: UniProtKB:Q9Y6Q9-1, Arg-1163, MOD:00658." [IEDB_epitope:569304, PRO:DNx]

organism-modification


PR:000072501
nuclear receptor coactivator 3 deaminated 1 (human)
hNCOA3/Deam:1
"A nuclear receptor coactivator 3 (human) that has been deaminated on the residue at the position equivalent to Gln-1358 of the amino acid sequence represented by UniProtKB:Q9Y6Q9-1. Example: UniProtKB:Q9Y6Q9-1, Gln-1358, MOD:00685." [IEDB_epitope:1583564, PRO:DNx]

organism-modification


PR:000077136
nuclear receptor coactivator 3 methylated 2 (human)
hNCOA3/Me:2
"A nuclear receptor coactivator 3 (human) that has been methylated on the residue at the position equivalent to Arg-849 of the amino acid sequence represented by UniProtKB:Q9Y6Q9-1. Example: UniProtKB:Q9Y6Q9-1, Arg-849, MOD:00658." [IEDB_epitope:569293, PRO:DNx]

organism-modification


PR:000083099
nuclear receptor coactivator 3 deaminated 2 (human)
hNCOA3/Deam:2
"A nuclear receptor coactivator 3 (human) that has been deaminated on the residue at the position equivalent to Gln-1380 of the amino acid sequence represented by UniProtKB:Q9Y6Q9-1. Example: UniProtKB:Q9Y6Q9-1, Gln-1380, MOD:00685." [IEDB_epitope:1584748, PRO:DNx]

organism-modification


PR:000085550
nuclear receptor coactivator 3 deaminated 3 (human)
hNCOA3/Deam:3
"A nuclear receptor coactivator 3 (human) that has been deaminated on the residue at the position equivalent to Gln-1379 of the amino acid sequence represented by UniProtKB:Q9Y6Q9-1. Example: UniProtKB:Q9Y6Q9-1, Gln-1379, MOD:00685." [IEDB_epitope:1584747, PRO:DNx]

sequence


PR:000027689
nuclear receptor coactivator 3 isoform 1
NCOA3/iso:1
"A nuclear receptor coactivator 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6Q9-1 or a 1:1 ortholog thereof." [PMID:18922467, PMID:21577200, PRO:PD]

organism-sequence


PR:Q9Y6Q9-1
nuclear receptor coactivator 3 isoform 1 (human)
hNCOA3/iso:1
"A nuclear receptor coactivator 3 isoform 1 that is encoded in the genome of human." [PRO:PD]

organism-modification


PR:000027692
nuclear receptor coactivator 3 isoform 1 phosphorylated 1 (human)
hNCOA3/iso:1/Phos:1
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6Q9-1, Ser-101/Ser-102, MOD:00046." [PMID:18922467, PMID:21577200, PRO:PD]
Yes
organism-modification


PR:000027694
nuclear receptor coactivator 3 isoform 1 phosphorylated 2 (human)
hNCOA3/iso:1/Phos:2
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6Q9-1, Ser-601, MOD:00046." [PMID:19339517, PRO:PD]
Yes
organism-modification


PR:000027696
nuclear receptor coactivator 3 isoform 1 phosphorylated 3 (human)
hNCOA3/iso:1/Phos:3
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6Q9-1, Tyr-1357, MOD:00048." [PMID:18765637, PRO:PD]
Yes
organism-modification


PR:000027698
nuclear receptor coactivator 3 isoform 1 phosphorylated 4 (human)
hNCOA3/iso:1/Phos:4
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 4 in human. UniProtKB:Q9Y6Q9-1, Ser-857, MOD:00046." [PMID:15383283, PRO:PD]

organism-modification


PR:000027885
nuclear receptor coactivator 3 isoform 1 acetylated 1 (human)
hNCOA3/iso:1/Ac:1
"A nuclear receptor coactivator 3 isoform 1 acetylated 1 in human. UniProtKB:Q9Y6Q9-1, Lys-619/Lys-620, MOD:00064." [PMID:10490106, PRO:PD]
Yes
organism-modification


PR:000027887
nuclear receptor coactivator 3 isoform 1 acetylated 2 (human)
hNCOA3/iso:1/Ac:2
"A nuclear receptor coactivator 3 isoform 1 acetylated 2 in human. UniProtKB:Q9Y6Q9-1, Lys-687, MOD:00064." [PMID:19608861, PRO:PD]

modification


PR:000027691
nuclear receptor coactivator 3 isoform 1 phosphorylated 1
NCOA3/iso:1/Phos:1
"A nuclear receptor coactivator 3 isoform 1 that has been phosphorylated on Ser residues by Casein kinase I. Example: UniProtKB:Q9Y6Q9-1, Ser-101/Ser-102, MOD:00046." [PMID:18922467, PMID:21577200, PRO:PD]

organism-modification


PR:000027692
nuclear receptor coactivator 3 isoform 1 phosphorylated 1 (human)
hNCOA3/iso:1/Phos:1
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6Q9-1, Ser-101/Ser-102, MOD:00046." [PMID:18922467, PMID:21577200, PRO:PD]
Yes
modification


PR:000027693
nuclear receptor coactivator 3 isoform 1 phosphorylated 2
NCOA3/iso:1/Phos:2
"A nuclear receptor coactivator 3 isoform 1 that has been phosphorylated on a Ser residue within the RID domain. Example: UniProtKB:Q9Y6Q9-1, Ser-601, MOD:00046." [PMID:19339517, PRO:PD]

organism-modification


PR:000027694
nuclear receptor coactivator 3 isoform 1 phosphorylated 2 (human)
hNCOA3/iso:1/Phos:2
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6Q9-1, Ser-601, MOD:00046." [PMID:19339517, PRO:PD]
Yes
modification


PR:000027695
nuclear receptor coactivator 3 isoform 1 phosphorylated 3
NCOA3/iso:1/Phos:3
"A nuclear receptor coactivator 3 isoform 1 that has been phosphorylated on a C-terminal Tyr residue after the Gln rich region. Example: UniProtKB:Q9Y6Q9-1, Tyr-1357, MOD:00048." [PMID:18765637, PRO:PD]

organism-modification


PR:000027696
nuclear receptor coactivator 3 isoform 1 phosphorylated 3 (human)
hNCOA3/iso:1/Phos:3
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6Q9-1, Tyr-1357, MOD:00048." [PMID:18765637, PRO:PD]
Yes
modification


PR:000027697
nuclear receptor coactivator 3 isoform 1 phosphorylated 4
NCOA3/iso:1/Phos:4
"A nuclear receptor coactivator 3 isoform 1 that has been phosphorylated on the residue at the position equivalent to Ser-857 of the amino acid sequence represented by UniProtKB:Q9Y6Q9-1. Example: UniProtKB:Q9Y6Q9-1, Ser-857, MOD:00046." [PMID:15383283, PRO:PD]

organism-modification


PR:000027698
nuclear receptor coactivator 3 isoform 1 phosphorylated 4 (human)
hNCOA3/iso:1/Phos:4
"A nuclear receptor coactivator 3 isoform 1 phosphorylated 4 in human. UniProtKB:Q9Y6Q9-1, Ser-857, MOD:00046." [PMID:15383283, PRO:PD]

modification


PR:000027884
nuclear receptor coactivator 3 isoform 1 acetylated 1
NCOA3/iso:1/Ac:1
"A nuclear receptor coactivator 3 isoform 1 that is acetylated on the Lys residues at -1 and -2 positions of the first LxxLL motif (conserved sequence KKLLQLL). Example: UniProtKB:Q9Y6Q9-1, Lys-619/Lys-620, MOD:00064." [PMID:10490106, PRO:PD]

organism-modification


PR:000027885
nuclear receptor coactivator 3 isoform 1 acetylated 1 (human)
hNCOA3/iso:1/Ac:1
"A nuclear receptor coactivator 3 isoform 1 acetylated 1 in human. UniProtKB:Q9Y6Q9-1, Lys-619/Lys-620, MOD:00064." [PMID:10490106, PRO:PD]
Yes
modification


PR:000027886
nuclear receptor coactivator 3 isoform 1 acetylated 2
NCOA3/iso:1/Ac:2
"A nuclear receptor coactivator 3 isoform 1 that is acetylated on the Lys residue within the second LxxLL motif (conserved sequence LHKLL). Example: UniProtKB:Q9Y6Q9-1, Lys-687, MOD:00064." [PMID:19608861, PRO:PD]

organism-modification


PR:000027887
nuclear receptor coactivator 3 isoform 1 acetylated 2 (human)
hNCOA3/iso:1/Ac:2
"A nuclear receptor coactivator 3 isoform 1 acetylated 2 in human. UniProtKB:Q9Y6Q9-1, Lys-687, MOD:00064." [PMID:19608861, PRO:PD]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027692 hNCOA3/iso:1/Phos:1
UniProtKB:Q9Y6Q9-1, Ser-101/Ser-102, MOD:00046		 enablesGO:0005515 protein binding with PR:O43791 HIB homolog 1 (human) PMID:21577200
PR:000027694 hNCOA3/iso:1/Phos:2
UniProtKB:Q9Y6Q9-1, Ser-601, MOD:00046		 acts_upstream_of_or_withinGO:0030374 nuclear receptor coactivator activity PMID:19339517
enablesGO:0003713 transcription coactivator activity PMID:19339517
PR:000027696 hNCOA3/iso:1/Phos:3
UniProtKB:Q9Y6Q9-1, Tyr-1357, MOD:00048		 acts_upstream_of_or_withinGO:0030374 nuclear receptor coactivator activity PMID:18765637
enablesGO:0030331 nuclear estrogen receptor binding with PR:000007204 ER PMID:18765637
GO:0035035 histone acetyltransferase binding PMID:18765637
PR:000027885 hNCOA3/iso:1/Ac:1
UniProtKB:Q9Y6Q9-1, Lys-619/Lys-620, MOD:00064		 enablesNOT GO:0016922 nuclear receptor binding PMID:10490106