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Protein Ontology report - presenilin-2
PR:000013345 - http://purl.obolibrary.org/obo/PR_000013345
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000013345   
  PRO namepresenilin-2 
  Synonyms
PRO-Short-label: EXACT:PSEN2
Gene-based: RELATED:AD4 | Ad4h | Alg3 | PS2 | PSNL2 | STM2
Other: EXACT:AD3LP | AD5 | E5-1 | PS-2 | STM-2
  Definition"A protein that is a translation product of the human PSEN2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  CommentRequested by=Alzforum. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 0                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2403
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000013345

presenilin-2

PSEN2


"A protein that is a translation product of the human PSEN2 gene or a 1:1 ortholog thereof." [PRO:DNx]






PR:000036851

presenilin-2 isoform 1











PR:000036881

presenilin-2 isoform 1 C-terminal fragment











PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)











PR:000036887

presenilin-2 isoform 1 N-terminal fragment











PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)











PR:000036889

presenilin-2 isoform 1 CTF subunit











PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)







organism-sequence



PR:P49810-1

presenilin-2 isoform 1 (human)

hPSEN2/iso:1


"A presenilin-2 isoform 1 that is encoded in the genome of human." [PMID:19376115, PRO:CNA]






PR:Q61144-1

presenilin-2 isoform 1 (mouse)











PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)











PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)











PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)











PR:000036853

presenilin-2 isoform PS2beta







organism-sequence



PR:000036856

presenilin-2 isoform PS2beta (human)

hPSEN2/iso:PS2beta


"A presenilin-2 isoform PS2beta that is encoded in the genome of human." [PMID:19376115, PRO:CNA]






PR:Q61144-2

presenilin-2 isoform PS2beta (mouse)











PR:000036857

presenilin-2 isoform PS2short











PR:000036858

presenilin-2 isoform PS2short (mouse)











PR:000036880

presenilin-2 proteolytic cleavage product











PR:000036881

presenilin-2 isoform 1 C-terminal fragment











PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)











PR:000036887

presenilin-2 isoform 1 N-terminal fragment











PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)











PR:000036889

presenilin-2 isoform 1 CTF subunit











PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)







organism-gene



PR:O02194

presenilin homolog (fruit fly)

fly-PSEN2


"A presenilin-2 that is encoded in the genome of fruit fly." [OMA:O02194, PRO:DNx]


organism-sequence



PR:O02194-1

presenilin homolog isoform 1 (fruit fly)

fly-PSEN2/iso:1


"A presenilin homolog (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O02194-1." [PRO:DNx, UniProtKB:O02194]


organism-sequence



PR:O02194-2

presenilin homolog isoform 2 (fruit fly)

fly-PSEN2/iso:2


"A presenilin homolog (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O02194-2." [PRO:DNx, UniProtKB:O02194]


organism-sequence



PR:O02194-3

presenilin homolog isoform 3 (fruit fly)

fly-PSEN2/iso:3


"A presenilin homolog (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O02194-3." [PRO:DNx, UniProtKB:O02194]






PR:O88777

presenilin-2 (rat)







organism-gene



PR:P49810

presenilin-2 (human)

hPSEN2


"A presenilin-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49810]


organism-sequence



PR:000036286

presenilin-2 sequence variant (human)

hPSEN2/var+


"A presenilin-2 (human) that has at least one amino acid residue that differs from the corresponding residue found in another presenilin-2 (human) when such a difference arises as the result of genetic differences, i.e., different alleles of presenilin-2 (human). Operationally, this means the sequence representation of the presenilin-2 (human) has at least one amino acid residue that differs from the corresponding residue found in the sequence represened by UniProtKB:P49810-1." [PRO:DAN]






PR:000037741

presenilin-2 sequence variant R29H (human)











PR:000037742

presenilin-2 sequence variant G34S (human)











PR:000037743

presenilin-2 sequence variant R62H (human)











PR:000037744

presenilin-2 sequence variant R62C (human)











PR:000037745

presenilin-2 sequence variant P69A (human)











PR:000037746

presenilin-2 sequence variant R71W (human)











PR:000037747

presenilin-2 sequence variant A85V (human)











PR:000037748

presenilin-2 sequence variant T122P (human)











PR:000037749

presenilin-2 sequence variant T122R (human)











PR:000037750

presenilin-2 sequence variant E126K (human)











PR:000037751

presenilin-2 sequence variant S130L (human)











PR:000037752

presenilin-2 sequence variant V139M (human)











PR:000037753

presenilin-2 sequence variant N141I (human)











PR:000037754

presenilin-2 sequence variant N141Y (human)











PR:000037755

presenilin-2 sequence variant L143H (human)











PR:000037756

presenilin-2 sequence variant V148I (human)











PR:000037757

presenilin-2 sequence variant R163H (human)











PR:000037758

presenilin-2 sequence variant M174V (human)











PR:000037759

presenilin-2 sequence variant S175C (human)











PR:000037760

presenilin-2 sequence variant V214L (human)











PR:000037761

presenilin-2 sequence variant Q228L (human)











PR:000037762

presenilin-2 sequence variant Y231C (human)











PR:000037763

presenilin-2 sequence variant M239V (human)











PR:000037764

presenilin-2 sequence variant M239I (human)







organism-sequence



PR:000037765

presenilin-2 sequence variant A252T (human)

hPSEN2/var:A252T


"A presenilin-2 sequence variant (human) that has a Thr residue at the position equivalent to Ala-252 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-252, CHEBI:30013." [Alzforum:KD, PMID:18667258, PRO:DAN]






PR:000037766

presenilin-2 sequence variant P334R (human)











PR:000037767

presenilin-2 sequence variant V393M (human)











PR:000037768

presenilin-2 sequence variant T430M (human)











PR:000037769

presenilin-2 sequence variant D439A (human)











PR:000044560

presenilin-2 sequence variant G212V (human)











PR:000044561

presenilin-2 sequence variant L238P (human)











PR:000044562

presenilin-2 sequence variant P348L (human)











PR:000044563

presenilin-2 sequence variant T18M (human)











PR:000045476

presenilin-2 sequence variant K82R (human)











PR:000045477

presenilin-2 sequence variant V101M (human)











PR:000045478

presenilin-2 sequence variant P123L (human)











PR:000045479

presenilin-2 sequence variant K161R (human)











PR:000045480

presenilin-2 sequence variant H169N (human)











PR:000045481

presenilin-2 sequence variant I235F (human)







organism-sequence



PR:000045482

presenilin-2 sequence variant A237V (human)

hPSEN2/var:A237V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Ala-237 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-237, CHEBI:30015." [Alzforum:KD, PMID:25104557, PRO:DAN]






PR:000045483

presenilin-2 sequence variant L238F (human)







organism-sequence



PR:000045484

presenilin-2 sequence variant A258T (human)

hPSEN2/var:A258T


"A presenilin-2 sequence variant (human) that has a Thr residue at the position equivalent to Ala-258 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-258, CHEBI:30013." [Alzforum:KD, PMID:25937274, PRO:DAN]






PR:000045485

presenilin-2 sequence variant T301M (human)











PR:000045486

presenilin-2 sequence variant P334A (human)







organism-sequence



PR:000045487

presenilin-2 sequence variant A377V (human)

hPSEN2/var:A377V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Ala-377 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-377, CHEBI:30015." [Alzforum:KD, PMID:25333068, PRO:DAN]


organism-sequence



PR:000036856

presenilin-2 isoform PS2beta (human)

hPSEN2/iso:PS2beta


"A presenilin-2 isoform PS2beta that is encoded in the genome of human." [PMID:19376115, PRO:CNA]


organism-sequence



PR:P49810-1

presenilin-2 isoform 1 (human)

hPSEN2/iso:1


"A presenilin-2 isoform 1 that is encoded in the genome of human." [PMID:19376115, PRO:CNA]


organism-sequence



PR:P49810-2

presenilin-2 isoform h2 (human)

hPSEN2/iso:h2


"A presenilin-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49810-2." [PRO:DNx, UniProtKB:P49810]


organism-sequence



PR:P49810-3

presenilin-2 isoform h3 (human)

hPSEN2/iso:h3


"A presenilin-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49810-3." [PRO:DNx, UniProtKB:P49810]


organism-gene



PR:P52166

presenilin sel-12 (worm)

PSEN2 (worm)


"A presenilin-2 that is encoded in the genome of worm." [OMA:P52166, PRO:DNx]






PR:Q61144

presenilin-2 (mouse)











PR:000036858

presenilin-2 isoform PS2short (mouse)











PR:000036891

PS2s (mouse)











PR:000036858

presenilin-2 isoform PS2short (mouse)











PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)











PR:Q61144-1

presenilin-2 isoform 1 (mouse)











PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)











PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)











PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)











PR:Q61144-2

presenilin-2 isoform PS2beta (mouse)











PR:Q90ZE4

presenilin-2 (zebrafish)