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Protein Ontology report - receptor-interacting serine/threonine-protein kinase 1
PR:000014022 - http://purl.obolibrary.org/obo/PR_000014022
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014022   
  PRO namereceptor-interacting serine/threonine-protein kinase 1 
  Synonyms
PRO-Short-label: EXACT:RIPK1
Gene-based: RELATED:Rinp | RIP | RIP1
Other: EXACT:cell death protein RIP | receptor-interacting protein 1 | RIP-1 | serine/threonine-protein kinase RIP
  Definition"A protein that is a translation product of the human RIPK1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification3                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038820;IUPHARobj:2189
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000014022

receptor-interacting serine/threonine-protein kinase 1

RIPK1


"A protein that is a translation product of the human RIPK1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q13546

receptor-interacting serine/threonine-protein kinase 1 (human)

hRIPK1


"A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:000060700

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324N (human)

hRIPK1/var:D324N


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has an Asn residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9693930]


organism-sequence



PR:000061515

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324V (human)

hRIPK1/var:D324V


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9693927]


organism-sequence



PR:000061610

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324Y (human)

hRIPK1/var:D324Y


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has a Tyr residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-9693931]


organism-sequence



PR:000062596

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324H (human)

hRIPK1/var:D324H


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has a His residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-9693922]


organism-sequence



PR:Q13546-1

receptor-interacting serine/threonine-protein kinase 1 isoform 1 (human)

hRIPK1/iso:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CC]


organism-modification



PR:000036649

receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 (human)

hRIPK1/iso:1/Ubiq:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 in human." [PMID:19734906, PRO:CNA]

Yes

organism-sequence



PR:Q13546-2

receptor-interacting serine/threonine-protein kinase 1 isoform h2 (human)

hRIPK1/iso:h2


"A receptor-interacting serine/threonine-protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13546-2." [PRO:DNx, UniProtKB:Q13546]


organism-modification



PR:000036051

receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human)

hRIPK1/K63polyUbiq:1


"A receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 in human. UniProtKB:Q13546, Lys-377, PR:000044772." [Reactome:R-HSA-937021]

Yes

Yes
organism-modification



PR:000049045

receptor-interacting serine/threonine-protein kinase 1 phosphoserine form (human)

hRIPK1/PhosSer+


"A receptor-interacting serine/threonine-protein kinase 1 (human) that includes at least one phosphorylated serine. UniProtKB:Q13546, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218872]


organism-modification



PR:000062016

receptor-interacting serine/threonine-protein kinase 1 phosphorylated 1 (human)

hRIPK1/Phos:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-357 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Ser-357, MOD:00046." [PRO:DNx, Reactome:R-HSA-9819116]


organism-modification



PR:000063041

receptor-interacting serine/threonine-protein kinase 1 phosphorylated 2 (human)

hRIPK1/Phos:2


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Ser-320, MOD:00046." [PRO:DNx, Reactome:R-HSA-9815498]


organism-modification



PR:000064671

receptor-interacting serine/threonine-protein kinase 1 ubiquitinated 1 (human)

hRIPK1/Ubiq:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been ubiquitinated on the residues at the positions equivalent to Lys-571, Lys-604, and Lys-627 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Lys-571/Lys-604/Lys-627, MOD:01148." [PRO:DNx, Reactome:R-HSA-9796639]


organism-modification



PR:000064778

receptor-interacting serine/threonine-protein kinase 1 ubiquitinated form (human)

hRIPK1/UbiqLys+


"A receptor-interacting serine/threonine-protein kinase 1 (human) that includes at least 1 ubiquitinated lysine. UniProtKB:Q13546, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783197, Reactome:R-HSA-6783308]


organism-modification



PR:000064853

receptor-interacting serine/threonine-protein kinase 1 ubiquitinated 2 (human)

hRIPK1/Ubiq:2


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been ubiquitinated on the residues at the positions equivalent to Lys-377, Lys-604, and Lys-634 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Lys-377/Lys-604/Lys-634, MOD:01148." [PRO:DNx, Reactome:R-HSA-9818391]


organism-modification



PR:000069926

receptor-interacting serine/threonine-protein kinase 1 methylated 1 (human)

hRIPK1/Me:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-656 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Cys-656, MOD:00660." [IEDB_epitope:1018920, PRO:DNx]


organism-modification



PR:000075119

receptor-interacting serine/threonine-protein kinase 1 cysteinylated 1 (human)

hRIPK1/Cyst:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-656 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Cys-656, MOD:00765." [IEDB_epitope:927758, PRO:DNx]


organism-gene



PR:Q60855

receptor-interacting serine/threonine-protein kinase 1 (mouse)

mRIPK1


"A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of mouse." [OMA:Q60855, PRO:CNA]


Yes
organism-sequence



PR:Q60855-1

receptor-interacting serine/threonine-protein kinase 1 isoform 1 (mouse)

mRIPK1/iso:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CC]


organism-modification



PR:000036107

receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (mouse)

mRIPK1/K63polyUbiq:1


"A receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 in mouse. UniProtKB:Q60855, Lys-376, PR:000044772." [PMID:17702576, PRO:CNA, PRO:DAN, PRO:KRC]


Yes
sequence



PR:000021967

receptor-interacting serine/threonine-protein kinase 1 isoform 1

RIPK1/iso:1


"A receptor-interacting serine/threonine-protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13546-1 or a 1:1 ortholog thereof." [PRO:CC]


organism-sequence



PR:Q13546-1

receptor-interacting serine/threonine-protein kinase 1 isoform 1 (human)

hRIPK1/iso:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CC]


organism-modification



PR:000036649

receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 (human)

hRIPK1/iso:1/Ubiq:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 in human." [PMID:19734906, PRO:CNA]

Yes

organism-sequence



PR:Q60855-1

receptor-interacting serine/threonine-protein kinase 1 isoform 1 (mouse)

mRIPK1/iso:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CC]


modification



PR:000021969

receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated form

RIPK1/iso:1/UbiqLys+


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]


modification



PR:000021970

receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1

RIPK1/iso:1/Ubiq:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated form that has been polyubiquitinated by E3 ubiquitin-protein ligase pellino homolog 1 (PR:000003141)." [PMID:19734906, TLR:AMM]


organism-modification



PR:000036649

receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 (human)

hRIPK1/iso:1/Ubiq:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 in human." [PMID:19734906, PRO:CNA]

Yes

modification



PR:000036050

receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1

RIPK1/K63polyUbiq:1


"A receptor-interacting serine/threonine-protein kinase 1 that has been cross-linked to K63-linked polyubiquitin. Example: UniProtKB:Q13546, Lys-377, PR:000044772." [PRO:CNA]


organism-modification



PR:000036051

receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human)

hRIPK1/K63polyUbiq:1


"A receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 in human. UniProtKB:Q13546, Lys-377, PR:000044772." [Reactome:R-HSA-937021]

Yes

Yes
organism-modification



PR:000036107

receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (mouse)

mRIPK1/K63polyUbiq:1


"A receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 in mouse. UniProtKB:Q60855, Lys-376, PR:000044772." [PMID:17702576, PRO:CNA, PRO:DAN, PRO:KRC]


Yes
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RIPK1 forms found in complexes   

RIPK1 Component
Complexes
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000036107 mRIPK1/K63polyUbiq:1 PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:Q13546 hRIPK1 PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000028437 TRAF2:TRADD:RIP1:FADD (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q60855 mRIPK1 PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005515 protein bindingPR:000036649 hRIPK1/iso:1/Ubiq:1 PMID:19734906

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005737 cytoplasmPR:000036051 hRIPK1/K63polyUbiq:1 Reactome:REACT_26236