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Protein Ontology report - sonic hedgehog protein
PR:000014841 -
http://purl.obolibrary.org/obo/PR_000014841
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000014841
PRO name
sonic hedgehog protein
Synonyms
PRO-Short-label
:
EXACT:
SHH
Gene-based
:
RELATED:
Hhg1
Other
:
EXACT:
HHG-1 | Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains | ShhNC
Definition
"A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." [PRO:DNx]
PRO Category
gene
Parent
PR:000000001
protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
5
Sequence
0
Organism-Sequence
0
Modification
4
Organism-Modification
30
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
gene
PR:000014841
sonic hedgehog protein
SHH
"A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." [PRO:DNx]
organism-gene
PR:Q15465
sonic hedgehog protein (human)
hSHH
"A sonic hedgehog protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15465]
organism-modification
PR:000037274
sonic hedgehog protein N-product dually lipidated 1 (human)
hSHH/Clv:Nter/2*Lipid:1
"A sonic hedgehog protein N-product in human that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q15465, 24-197, Cys-24, MOD:00069|Gly-197, MOD:00314." [PMID:9593755, PRO:CNA]
organism-modification
PR:000060317
sonic hedgehog protein sequence variant L382P, signal peptide removed form (human)
hSHH/var:L382P/SigPep-
"A sonic hedgehog protein (human) that has a Pro residue at the position equivalent to Leu-382 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Leu-382, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5358428]
organism-modification
PR:000060418
sonic hedgehog protein sequence variant G196V, signal peptide removed form (human)
hSHH/var:G196V/SigPep-
"A sonic hedgehog protein (human) that has a Val residue at the position equivalent to Gly-196 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Gly-196, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-5358433]
organism-modification
PR:000060438
sonic hedgehog protein sequence variant C198S, signal peptide removed ubiquitinated form (human)
hSHH/var:C198S/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Ser residue at the position equivalent to Cys-198 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Cys-198, CHEBI:29999|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387341, Reactome:R-HSA-5387354]
organism-modification
PR:000060458
sonic hedgehog protein sequence variant G196V, signal peptide removed ubiquitinated form (human)
hSHH/var:G196V/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Val residue at the position equivalent to Gly-196 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Gly-196, CHEBI:30015|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387343, Reactome:R-HSA-5387362]
organism-modification
PR:000060483
sonic hedgehog protein sequence variant W117G, signal peptide removed ubiquitinated form (human)
hSHH/var:W117G/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Gly residue at the position equivalent to Trp-117 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Trp-117, CHEBI:29947|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387345, Reactome:R-HSA-5387361]
organism-modification
PR:000060485
sonic hedgehog protein sequence variant W117G, signal peptide removed form (human)
hSHH/var:W117G/SigPep-
"A sonic hedgehog protein (human) that has a Gly residue at the position equivalent to Trp-117 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Trp-117, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-5358404]
organism-modification
PR:000060562
sonic hedgehog protein sequence variant W117R, signal peptide removed form (human)
hSHH/var:W117R/SigPep-
"A sonic hedgehog protein (human) that has an Arg residue at the position equivalent to Trp-117 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Trp-117, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-5358401]
organism-modification
PR:000060621
sonic hedgehog protein sequence variant A373T, signal peptide removed form (human)
hSHH/var:A373T/SigPep-
"A sonic hedgehog protein (human) that has a Thr residue at the position equivalent to Ala-373 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Ala-373, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-5358448]
organism-modification
PR:000060800
sonic hedgehog protein sequence variant F377S, signal peptide removed form (human)
hSHH/var:F377S/SigPep-
"A sonic hedgehog protein (human) that has a Ser residue at the position equivalent to Phe-377 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Phe-377, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-5358427]
organism-modification
PR:000060869
sonic hedgehog protein sequence variant R381P, signal peptide removed ubiquitinated form (human)
hSHH/var:R381P/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Pro residue at the position equivalent to Arg-381 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Arg-381, CHEBI:50342|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387342, Reactome:R-HSA-5387359]
organism-modification
PR:000061125
sonic hedgehog protein sequence variant A376D, signal peptide removed form (human)
hSHH/var:A376D/SigPep-
"A sonic hedgehog protein (human) that has an Asp residue at the position equivalent to Ala-376 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Ala-376, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-5358445]
organism-modification
PR:000061219
sonic hedgehog protein sequence variant F377S, signal peptide removed ubiquitinated form (human)
hSHH/var:F377S/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Ser residue at the position equivalent to Phe-377 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Phe-377, CHEBI:29999|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387351, Reactome:R-HSA-5387364]
organism-modification
PR:000061558
sonic hedgehog protein sequence variant G196E, signal peptide removed form (human)
hSHH/var:G196E/SigPep-
"A sonic hedgehog protein (human) that has a Glu residue at the position equivalent to Gly-196 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Gly-196, CHEBI:29972." [PRO:DNx, Reactome:R-HSA-5358437]
organism-modification
PR:000061958
sonic hedgehog protein sequence variant A383T, signal peptide removed form (human)
hSHH/var:A383T/SigPep-
"A sonic hedgehog protein (human) that has a Thr residue at the position equivalent to Ala-383 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Ala-383, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-5358444]
organism-modification
PR:000062404
sonic hedgehog protein sequence variant C198S, signal peptide removed form (human)
hSHH/var:C198S/SigPep-
"A sonic hedgehog protein (human) that has a Ser residue at the position equivalent to Cys-198 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Cys-198, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-5358439]
organism-modification
PR:000062597
sonic hedgehog protein sequence variant G196E, signal peptide removed ubiquitinated form (human)
hSHH/var:G196E/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Glu residue at the position equivalent to Gly-196 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Gly-196, CHEBI:29972|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387339, Reactome:R-HSA-5387356]
organism-modification
PR:000062637
sonic hedgehog protein sequence variant A383T, signal peptide removed ubiquitinated form (human)
hSHH/var:A383T/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Thr residue at the position equivalent to Ala-383 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Ala-383, CHEBI:30013|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387348, Reactome:R-HSA-5387366]
organism-modification
PR:000062821
sonic hedgehog protein sequence variant A376D, signal peptide removed ubiquitinated form (human)
hSHH/var:A376D/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has an Asp residue at the position equivalent to Ala-376 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Ala-376, CHEBI:29958|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387340, Reactome:R-HSA-5387355]
organism-modification
PR:000062925
sonic hedgehog protein sequence variant A373T, signal peptide removed ubiquitinated form (human)
hSHH/var:A373T/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Thr residue at the position equivalent to Ala-373 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Ala-373, CHEBI:30013|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387346, Reactome:R-HSA-5387363]
organism-modification
PR:000063074
sonic hedgehog protein sequence variant W117R, signal peptide removed ubiquitinated form (human)
hSHH/var:W117R/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has an Arg residue at the position equivalent to Trp-117 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Trp-117, CHEBI:29952|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387347, Reactome:R-HSA-5387353]
organism-modification
PR:000063484
sonic hedgehog protein, signal peptide removed form (human)
hSHH/SigPep-
"A sonic hedgehog protein (human) that has had the signal peptide removed. UniProtKB:Q15465, 24-462." [PRO:DNx, Reactome:R-HSA-9815791]
organism-modification
PR:000063556
sonic hedgehog protein sequence variant R381P, signal peptide removed form (human)
hSHH/var:R381P/SigPep-
"A sonic hedgehog protein (human) that has a Pro residue at the position equivalent to Arg-381 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Arg-381, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5358425]
organism-modification
PR:000063771
sonic hedgehog protein sequence variant C198F, signal peptide removed ubiquitinated form (human)
hSHH/var:C198F/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Phe residue at the position equivalent to Cys-198 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Cys-198, CHEBI:29997|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387349, Reactome:R-HSA-5387365]
organism-modification
PR:000063895
sonic hedgehog protein sequence variant C198F, signal peptide removed form (human)
hSHH/var:C198F/SigPep-
"A sonic hedgehog protein (human) that has a Phe residue at the position equivalent to Cys-198 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, Cys-198, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-5358441]
organism-modification
PR:000064527
sonic hedgehog protein sequence variant H374R, signal peptide removed form (human)
hSHH/var:H374R/SigPep-
"A sonic hedgehog protein (human) that has an Arg residue at the position equivalent to His-374 of the amino acid sequence represented by UniProtKB:Q15465 and that has had the signal peptide removed. UniProtKB:Q15465, 24-462, His-374, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-5358430]
organism-modification
PR:000064548
sonic hedgehog protein sequence variant L382P, signal peptide removed ubiquitinated form (human)
hSHH/var:L382P/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has a Pro residue at the position equivalent to Leu-382 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, Leu-382, CHEBI:50342|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387344, Reactome:R-HSA-5387357]
organism-modification
PR:000064560
sonic hedgehog protein sequence variant H374R, signal peptide removed ubiquitinated form (human)
hSHH/var:H374R/SigPep-/UbiqLys+
"A sonic hedgehog protein (human) that has an Arg residue at the position equivalent to His-374 of the amino acid sequence represented by UniProtKB:Q15465, that has had the signal peptide removed, and that includes at least 1 ubiquitinated lysine. UniProtKB:Q15465, 24-462, His-374, CHEBI:29952|MOD:01148." [PRO:DNx, Reactome:R-HSA-5387352, Reactome:R-HSA-5387360]
organism-gene
PR:Q62226
sonic hedgehog protein (mouse)
mSHH
"A sonic hedgehog protein that is encoded in the genome of mouse." [OMA:Q62226, PRO:DNx]
organism-modification
PR:000037272
sonic hedgehog protein, signal peptide removed form (mouse)
mSHH/SigPep-
"A sonic hedgehog protein, signal peptide removed form in mouse. UniProtKB:Q62226, 25-437." [PMID:18794898, PRO:CNA]
organism-modification
PR:000037269
sonic hedgehog protein N-product dually lipidated 1 (mouse)
mSHH/Clv:Nter/2*Lipid:1
"A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314." [PMID:15075292, PMID:8824192, PRO:KRC]
Yes
organism-gene
PR:Q63673
sonic hedgehog protein (rat)
rSHH
"A sonic hedgehog protein that is encoded in the genome of rat." [OMA:Q63673, PRO:DNx]
organism-gene
PR:Q91035
sonic hedgehog protein (chicken)
chick-SHH
"A sonic hedgehog protein that is encoded in the genome of chicken." [OMA:Q91035, PRO:DNx]
organism-gene
PR:Q92008
sonic hedgehog protein (zebrafish)
z-SHH
"A sonic hedgehog protein that is encoded in the genome of zebrafish." [PRO:DNx]
modification
PR:000021467
sonic hedgehog protein, signal peptide removed form
SHH/SigPep-
"A sonic hedgehog protein that has had the signal peptide removed." [PRO:DNx]
modification
PR:000037273
sonic hedgehog protein N-product
SHH/Clv:Nter
"A sonic hedgehog protein, signal peptide removed form that is the N-terminal product after autolysis. The N-product is the active species in signal transduction." [PRO:CNA]
organism-modification
PR:000037269
sonic hedgehog protein N-product dually lipidated 1 (mouse)
mSHH/Clv:Nter/2*Lipid:1
"A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314." [PMID:15075292, PMID:8824192, PRO:KRC]
Yes
organism-modification
PR:000037274
sonic hedgehog protein N-product dually lipidated 1 (human)
hSHH/Clv:Nter/2*Lipid:1
"A sonic hedgehog protein N-product in human that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q15465, 24-197, Cys-24, MOD:00069|Gly-197, MOD:00314." [PMID:9593755, PRO:CNA]
modification
PR:000037275
sonic hedgehog protein C-product
SHH/Clv:Cter
"A sonic hedgehog protein, signal peptide removed form that is the C-terminal product after autolysis. The C-product has autoproteolysis activity but does not participate in signal transduction." [PMID:24342078, PRO:CNA]
organism-modification
PR:000037272
sonic hedgehog protein, signal peptide removed form (mouse)
mSHH/SigPep-
"A sonic hedgehog protein, signal peptide removed form in mouse. UniProtKB:Q62226, 25-437." [PMID:18794898, PRO:CNA]
organism-modification
PR:000037269
sonic hedgehog protein N-product dually lipidated 1 (mouse)
mSHH/Clv:Nter/2*Lipid:1
"A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314." [PMID:15075292, PMID:8824192, PRO:KRC]
Yes
modification
PR:000021468
sonic hedgehog protein proteolytic cleavage product
SHH/ClvPrd
"A sonic hedgehog protein that has been processed by proteolytic cleavage." [PRO:DNx]
modification
PR:000037273
sonic hedgehog protein N-product
SHH/Clv:Nter
"A sonic hedgehog protein, signal peptide removed form that is the N-terminal product after autolysis. The N-product is the active species in signal transduction." [PRO:CNA]
organism-modification
PR:000037269
sonic hedgehog protein N-product dually lipidated 1 (mouse)
mSHH/Clv:Nter/2*Lipid:1
"A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314." [PMID:15075292, PMID:8824192, PRO:KRC]
Yes
organism-modification
PR:000037274
sonic hedgehog protein N-product dually lipidated 1 (human)
hSHH/Clv:Nter/2*Lipid:1
"A sonic hedgehog protein N-product in human that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q15465, 24-197, Cys-24, MOD:00069|Gly-197, MOD:00314." [PMID:9593755, PRO:CNA]
modification
PR:000037275
sonic hedgehog protein C-product
SHH/Clv:Cter
"A sonic hedgehog protein, signal peptide removed form that is the C-terminal product after autolysis. The C-product has autoproteolysis activity but does not participate in signal transduction." [PMID:24342078, PRO:CNA]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000037269
mSHH/Clv:Nter/2*Lipid:1
UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314
acts_upstream_of_or_within
GO:0007224
smoothened signaling pathway
MGI_ref:3039193;
PMID:15075292
GO:0009952
anterior/posterior pattern specification
MGI_ref:2135419;
PMID:11389830
GO:0030326
embryonic limb morphogenesis
MGI_ref:2135419;
PMID:11389830
GO:0042733
embryonic digit morphogenesis
MGI_ref:3039193;
PMID:15075292
