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Protein Ontology report - protein smoothened
PR:000015288 - http://purl.obolibrary.org/obo/PR_000015288
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000015288   
  PRO nameprotein smoothened 
  Synonyms
PRO-Short-label: EXACT:SMO
Gene-based: RELATED:SMOH
Other: EXACT:protein Gx
  Definition"A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof." [PRO:DAN] 
  PRO Categorygene 
  ParentPR:000001315 frizzled-like G-protein coupled receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:239
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000015288

protein smoothened

SMO


"A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof." [PRO:DAN]


organism-gene



PR:P56726

protein smoothened (mouse)

mSMO


"A protein smoothened that is encoded in the genome of mouse." [OMA:P56726, PRO:DNx]


organism-sequence



PR:P56726-1

protein smoothened isoform 1 (mouse)

mSMO/iso:1


"A protein smoothened isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P91682

protein smoothened (fruit fly)

fly-SMO


"A protein smoothened that is encoded in the genome of fruit fly." [PANTHER:PTHR11309:SF35, PRO:DNx]


organism-gene



PR:P97698

protein smoothened (rat)

rSMO


"A protein smoothened that is encoded in the genome of rat." [OMA:P97698, PRO:DNx]


organism-sequence



PR:P97698-1

protein smoothened isoform 1 (rat)

rSMO/iso:1


"A protein smoothened isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q5RH73

protein smoothened (zebrafish)

z-SMO


"A protein smoothened that is encoded in the genome of zebrafish." [OMA:Q5RH73, PRO:DNx]


organism-gene



PR:Q99835

protein smoothened (human)

hSMO


"A protein smoothened that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99835]


organism-modification



PR:000049297

protein smoothened, signal peptide removed form (human)

hSMO/SigPep-


"A protein smoothened (human) that has had the signal peptide removed. UniProtKB:Q99835, 28-787." [PRO:DNx, Reactome:R-HSA-445121, Reactome:R-HSA-5610419, Reactome:R-HSA-5610422, Reactome:R-HSA-5624094]


organism-modification



PR:000049298

protein smoothened, signal peptide removed phosphorylated 1 (human)

hSMO/SigPep-/Phos:1


"A protein smoothened (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 588, 590 and 595, and phosphothreonine at position 593 of the amino acid sequence represented by UniProtKB:Q99835. UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595, MOD:00046|Thr-593, MOD:00047." [PRO:DNx, Reactome:R-HSA-5632525]


organism-modification



PR:000049299

protein smoothened, signal peptide removed phosphorylated 2 (human)

hSMO/SigPep-/Phos:2


"A protein smoothened (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 588, 590, 595, 611, 615 and 616, and phosphothreonine at position 593 of the amino acid sequence represented by UniProtKB:Q99835. UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595/Ser-611/Ser-615/Ser-616, MOD:00046|Thr-593, MOD:00047." [PRO:DNx, Reactome:R-HSA-5632528]


organism-modification



PR:000057979

protein smoothened N-glycosylated 1 (human)

hSMO/NGlyco:1


"A protein smoothened (human) that has been N-glycosylated at the residue equivalent to Asn-35 of the amino acid sequence represented by UniProtKB:Q99835-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:Q99835-1, Asn-35, MOD:00160~GNO:G08293MJ." [GlyGen:Q99835-1, PMID:29671580, PRO:DNx]


organism-modification



PR:000057980

protein smoothened O-glycosylated 1 (human)

hSMO/OGlyco:1


"A protein smoothened (human) that has been O-glycosylated at the residue equivalent to Thr-500 of the amino acid sequence represented by UniProtKB:Q99835-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q99835-1, Thr-500, MOD:00005~GNO:G29068FM." [GlyGen:Q99835-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000057981

protein smoothened O-glycosylated 2 (human)

hSMO/OGlyco:2


"A protein smoothened (human) that has been O-glycosylated at the residue equivalent to Thr-55 of the amino acid sequence represented by UniProtKB:Q99835-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q99835-1, Thr-55, MOD:00005~GNO:G43417UB." [GlyGen:Q99835-1, PMID:30459171, PRO:DNx]


sequence



PR:000039833

protein smoothened isoform 1

SMO/iso:1


"A protein smoothened that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56726-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P56726-1

protein smoothened isoform 1 (mouse)

mSMO/iso:1


"A protein smoothened isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P97698-1

protein smoothened isoform 1 (rat)

rSMO/iso:1


"A protein smoothened isoform 1 that is encoded in the genome of rat." [PRO:DNx]