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Protein Ontology report - serine palmitoyltransferase 1
PR:000015596 - http://purl.obolibrary.org/obo/PR_000015596
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000015596   
  PRO nameserine palmitoyltransferase 1 
  Synonyms
PRO-Short-label: EXACT:SPTLC1
Gene-based: RELATED:LCB1
Other: EXACT:LCB 1 | long chain base biosynthesis protein 1 | serine-palmitoyl-CoA transferase 1 | SPT 1 | SPT1
  Definition"A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000026126 eukaryotic serine palmitoyltransferase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 8                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2509
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000015596 serine palmitoyltransferase 1
SPTLC1

organism-gene


PR:D4A2H2 serine palmitoyltransferase 1 (rat)
rSPTLC1

organism-gene


PR:O15269 serine palmitoyltransferase 1 (human)
hSPTLC1

Yes
organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human)
hSPTLC1/iso:1

organism-sequence


PR:O15269-2 serine palmitoyltransferase 1 isoform h2 (human)
hSPTLC1/iso:h2

organism-modification


PR:000045580 serine palmitoyltransferase 1 phosphorylated 1 (human)
hSPTLC1/Phos:1

organism-modification


PR:000061744 serine palmitoyltransferase 1 pyridoxal phosphate lysine form (human)
hSPTLC1/PyrdoxLys+

organism-modification


PR:000075626 serine palmitoyltransferase 1 cysteinylated 1 (human)
hSPTLC1/Cyst:1

organism-modification


PR:000078051 serine palmitoyltransferase 1 methylated 1 (human)
hSPTLC1/Me:1

organism-gene


PR:O35704 serine palmitoyltransferase 1 (mouse)
mSPTLC1
Yes
Yes
organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse)
mSPTLC1/iso:1
Yes
organism-gene


PR:O59682 serine palmitoyltransferase 1 (Schizosaccharomyces pombe 972h-)
Spom972h-SPTLC1

organism-gene


PR:P25045 serine palmitoyltransferase 1 (yeast)
ySPTLC1

organism-gene


PR:P91079 serine palmitoyltransferase 1 (worm)
SPTLC1 (worm)

organism-gene


PR:Q55FL5 serine palmitoyltransferase 1 (Dictyostelium discoideum)
Dicty-SPTLC1

organism-gene


PR:Q94IB8 long chain base biosynthesis protein 1 (Arabidopsis thaliana)
At-SPTLC1

sequence


PR:000022019 serine palmitoyltransferase 1 isoform 1
SPTLC1/iso:1

organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human)
hSPTLC1/iso:1

organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse)
mSPTLC1/iso:1
Yes
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SPTLC1 forms found in complexes   

SPTLC1 Component
 Complexes
PR:O15269 hSPTLC1 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O35704 mSPTLC1 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:O35704 mSPTLC1 acts_upstream_of_or_withinGO:0006686 sphingomyelin biosynthetic process PMID:16216550
GO:0046511 sphinganine biosynthetic process PMID:19416652
GO:0046512 sphingosine biosynthetic process PMID:16216550
GO:0046513 ceramide biosynthetic process PMID:16216550
PR:O35704-1 mSPTLC1/iso:1 enablesNOT GO:0004758 serine C-palmitoyltransferase activity PMID:9363775
GO:0005515 protein binding PMID:18484747