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Protein Ontology report - serine palmitoyltransferase 1
PR:000015596 - http://purl.obolibrary.org/obo/PR_000015596
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000015596   
  PRO nameserine palmitoyltransferase 1 
  Synonyms
PRO-Short-label: EXACT:SPTLC1
Gene-based: RELATED:LCB1
Other: EXACT:LCB 1 | long chain base biosynthesis protein 1 | serine-palmitoyl-CoA transferase 1 | SPT 1 | SPT1
  Definition"A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000026126 eukaryotic serine palmitoyltransferase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 8                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2509
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000015596

serine palmitoyltransferase 1

SPTLC1


"A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:D4A2H2

serine palmitoyltransferase 1 (rat)

rSPTLC1


"A serine palmitoyltransferase 1 that is encoded in the genome of rat." [OMA:D4A2H2, PRO:DNx]


organism-gene



PR:O15269

serine palmitoyltransferase 1 (human)

hSPTLC1


"A serine palmitoyltransferase 1 that is encoded in the genome of human." [PRO:CNA]


Yes
organism-sequence



PR:O15269-1

serine palmitoyltransferase 1 isoform 1 (human)

hSPTLC1/iso:1


"A serine palmitoyltransferase 1 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:O15269-2

serine palmitoyltransferase 1 isoform h2 (human)

hSPTLC1/iso:h2


"A serine palmitoyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15269-2." [PRO:DNx, UniProtKB:O15269]


organism-modification



PR:000045580

serine palmitoyltransferase 1 phosphorylated 1 (human)

hSPTLC1/Phos:1


"A serine palmitoyltransferase 1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-164 of the amino acid sequence represented by UniProtKB:O15269-1. Example: UniProtKB:O15269-1, Tyr-164, MOD:00048." [iPTMnet:O15269, PMID:23629659]


organism-modification



PR:000061744

serine palmitoyltransferase 1 pyridoxal phosphate lysine form (human)

hSPTLC1/PyrdoxLys+


"A serine palmitoyltransferase 1 (human) that includes at least 1 pyridoxal phosphate lysine. UniProtKB:O15269, MOD:00128." [PRO:DNx, Reactome:R-HSA-428155]


organism-modification



PR:000075626

serine palmitoyltransferase 1 cysteinylated 1 (human)

hSPTLC1/Cyst:1


"A serine palmitoyltransferase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-192 of the amino acid sequence represented by UniProtKB:O15269-1. Example: UniProtKB:O15269-1, Cys-192, MOD:00765." [IEDB_epitope:1057443, PRO:DNx]


organism-modification



PR:000078051

serine palmitoyltransferase 1 methylated 1 (human)

hSPTLC1/Me:1


"A serine palmitoyltransferase 1 (human) that has been methylated on the residue at the position equivalent to Cys-192 of the amino acid sequence represented by UniProtKB:O15269-1. Example: UniProtKB:O15269-1, Cys-192, MOD:00660." [IEDB_epitope:1057444, PRO:DNx]


organism-gene



PR:O35704

serine palmitoyltransferase 1 (mouse)

mSPTLC1


"A serine palmitoyltransferase 1 that is encoded in the genome of mouse." [OMA:O35704, PRO:HJD]

Yes

Yes
organism-sequence



PR:O35704-1

serine palmitoyltransferase 1 isoform 1 (mouse)

mSPTLC1/iso:1


"A serine palmitoyltransferase 1 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-gene



PR:O59682

serine palmitoyltransferase 1 (Schizosaccharomyces pombe 972h-)

Spom972h-SPTLC1


"A serine palmitoyltransferase 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O59682, PRO:DNx]


organism-gene



PR:P25045

serine palmitoyltransferase 1 (yeast)

ySPTLC1


"A serine palmitoyltransferase 1 that is encoded in the genome of yeast." [OMA:P25045, PRO:DNx]


organism-gene



PR:P91079

serine palmitoyltransferase 1 (worm)

SPTLC1 (worm)


"A serine palmitoyltransferase 1 that is encoded in the genome of worm." [OMA:P91079, PRO:DNx]


organism-gene



PR:Q55FL5

serine palmitoyltransferase 1 (Dictyostelium discoideum)

Dicty-SPTLC1


"A serine palmitoyltransferase 1 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q55FL5, PRO:DNx]


organism-gene



PR:Q94IB8

long chain base biosynthesis protein 1 (Arabidopsis thaliana)

At-SPTLC1


"A serine palmitoyltransferase 1 that is encoded in the genome of Arabidopsis thaliana." [OMA:Q94IB8, PRO:DNx]


sequence



PR:000022019

serine palmitoyltransferase 1 isoform 1

SPTLC1/iso:1


"A serine palmitoyltransferase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35704-1 or a 1:1 ortholog thereof." [PMID:9363775, PRO:HJD]


organism-sequence



PR:O15269-1

serine palmitoyltransferase 1 isoform 1 (human)

hSPTLC1/iso:1


"A serine palmitoyltransferase 1 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:O35704-1

serine palmitoyltransferase 1 isoform 1 (mouse)

mSPTLC1/iso:1


"A serine palmitoyltransferase 1 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

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SPTLC1 forms found in complexes   

SPTLC1 Component
Complexes
PR:O15269 hSPTLC1 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O35704 mSPTLC1 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006686 sphingomyelin biosynthetic processPR:O35704 mSPTLC1 PMID:16216550
GO:0046511 sphinganine biosynthetic processPR:O35704 mSPTLC1 PMID:19416652
GO:0046512 sphingosine biosynthetic processPR:O35704 mSPTLC1 PMID:16216550
GO:0046513 ceramide biosynthetic processPR:O35704 mSPTLC1 PMID:16216550

Molecular Function GO Term

Protein Forms & Complexes

Evidence
NOT GO:0004758 serine C-palmitoyltransferase activityPR:O35704-1 mSPTLC1/iso:1 PMID:9363775
GO:0005515 protein bindingPR:O35704-1 mSPTLC1/iso:1 PMID:18484747