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Protein Ontology report - serine palmitoyltransferase 2
PR:000015597 - http://purl.obolibrary.org/obo/PR_000015597
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000015597   
  PRO nameserine palmitoyltransferase 2 
  Synonyms
PRO-Short-label: EXACT:SPTLC2
Gene-based: RELATED:KIAA0526 | LCB2
Other: EXACT:LCB 2 | LCB2a | long chain base biosynthesis protein 2 | long chain base biosynthesis protein 2a | serine-palmitoyl-CoA transferase 2 | SPT 2
  Definition"A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000026126 eukaryotic serine palmitoyltransferase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2510
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000015597

serine palmitoyltransferase 2

SPTLC2


"A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O15270

serine palmitoyltransferase 2 (human)

hSPTLC2


"A serine palmitoyltransferase 2 that is encoded in the genome of human." [PRO:CNA]


Yes
organism-sequence



PR:O15270-1

serine palmitoyltransferase 2 isoform 1 (human)

hSPTLC2/iso:1


"A serine palmitoyltransferase 2 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-modification



PR:000049342

serine palmitoyltransferase 2 pyridoxal phosphate lysine 1 (human)

hSPTLC2/Pyrdox:1


"A serine palmitoyltransferase 2 (human) that has been post-translationally modified to include pyridoxal phosphate lysine at position 379 of the amino acid sequence represented by UniProtKB:O15270. UniProtKB:O15270, Lys-379, MOD:00128." [PRO:DNx, Reactome:R-HSA-428146]


organism-modification



PR:000073274

serine palmitoyltransferase 2 methylated 1 (human)

hSPTLC2/Me:1


"A serine palmitoyltransferase 2 (human) that has been methylated on the residue at the position equivalent to Cys-139 of the amino acid sequence represented by UniProtKB:O15270. UniProtKB:O15270, Cys-139, MOD:00660." [IEDB_epitope:1044187, PRO:DNx]


organism-modification



PR:000083083

serine palmitoyltransferase 2 methylated 2 (human)

hSPTLC2/Me:2


"A serine palmitoyltransferase 2 (human) that has been methylated on the residue at the position equivalent to Cys-204 of the amino acid sequence represented by UniProtKB:O15270. UniProtKB:O15270, Cys-204, MOD:00660." [IEDB_epitope:1016968, PRO:DNx]


organism-gene



PR:P97363

serine palmitoyltransferase 2 (mouse)

mSPTLC2


"A serine palmitoyltransferase 2 that is encoded in the genome of mouse." [OMA:P97363, PRO:HJD]

Yes

Yes
organism-sequence



PR:P97363-1

serine palmitoyltransferase 2 isoform 1 (mouse)

mSPTLC2/iso:1


"A serine palmitoyltransferase 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-gene



PR:Q3B7D2

serine palmitoyltransferase 2 (rat)

rSPTLC2


"A serine palmitoyltransferase 2 that is encoded in the genome of rat." [OMA:Q3B7D2, PRO:DNx]


sequence



PR:000022020

serine palmitoyltransferase 2 isoform 1

SPTLC2/iso:1


"A serine palmitoyltransferase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97363-1 or a 1:1 ortholog thereof." [PMID:8921873, PRO:HJD]


organism-sequence



PR:O15270-1

serine palmitoyltransferase 2 isoform 1 (human)

hSPTLC2/iso:1


"A serine palmitoyltransferase 2 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P97363-1

serine palmitoyltransferase 2 isoform 1 (mouse)

mSPTLC2/iso:1


"A serine palmitoyltransferase 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

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SPTLC2 forms found in complexes   

SPTLC2 Component
Complexes
PR:O15270 hSPTLC2 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:P97363 mSPTLC2 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006686 sphingomyelin biosynthetic processPR:P97363 mSPTLC2 PMID:16216550
GO:0046511 sphinganine biosynthetic processPR:P97363-1 mSPTLC2/iso:1 PMID:9363775
GO:0046512 sphingosine biosynthetic processPR:P97363 mSPTLC2 PMID:16216550
GO:0046513 ceramide biosynthetic processPR:P97363 mSPTLC2 PMID:16216550

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0004758 serine C-palmitoyltransferase activityPR:P97363-1 mSPTLC2/iso:1 PMID:9363775

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005739 mitochondrionPR:P97363-1 mSPTLC2/iso:1 PMID:18614015