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Protein Ontology report - dual specificity protein kinase TTK
PR:000016787 - http://purl.obolibrary.org/obo/PR_000016787
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000016787   
  PRO namedual specificity protein kinase TTK 
  Synonyms
PRO-Short-label: EXACT:TTK
Gene-based: RELATED:MPS1 | MPS1L1
Other: EXACT:ESK | Monopolar spindle protein 1 | phosphotyrosine picked threonine-protein kinase | PYT | Regulatory cell proliferation kinase 1
RELATED:RPK1 | serine/threonine-protein kinase MPS1
  Definition"A protein that is a translation product of the human TTK gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2264
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000016787 dual specificity protein kinase TTK
TTK

organism-gene


PR:P33981 dual specificity protein kinase TTK (human)
hTTK
Yes
organism-sequence


PR:P33981-1 dual specificity protein kinase TTK isoform h1 (human)
hTTK/iso:h1

organism-sequence


PR:P33981-2 dual specificity protein kinase TTK isoform h2 (human)
hTTK/iso:h2

organism-modification


PR:000045754 dual specificity protein kinase TTK phosphorylated 1 (human)
hTTK/Phos:1
Yes
organism-modification


PR:000049844 TTK activation loop phosphorylated form (human)
hTTK/(Act-loop)Phos+
Yes
organism-modification


PR:000049845 TTK activation loop and P+1 loop phosphorylated form (human)
hTTK/(Act-loop_P+1-loop)Phos+
Yes
organism-modification


PR:000083646 dual specificity protein kinase TTK methylated 1 (human)
hTTK/Me:1

organism-gene


PR:P35761 dual specificity protein kinase TTK (mouse)
mTTK

organism-sequence


PR:P35761-1 dual specificity protein kinase TTK isoform m1 (mouse)
mTTK/iso:m1

organism-sequence


PR:P35761-2 dual specificity protein kinase TTK isoform m2 (mouse)
mTTK/iso:m2

organism-modification


PR:000049885 dual specificity protein kinase TTK isoform m2 phosphorylated 1 (mouse)
mTTK/iso:m2/Phos:1

organism-modification


PR:000049886 dual specificity protein kinase TTK isoform m2 phosphorylated 2 (mouse)
mTTK/iso:m2/Phos:2

organism-modification


PR:000049884 dual specificity protein kinase TTK phosphorylated 1 (mouse)
mTTK/Phos:1

organism-gene


PR:P54199 serine/threonine-protein kinase MPS1 (yeast)
yTTK
Yes
organism-gene


PR:Q8AYG3 dual specificity protein kinase Ttk (zebrafish)
z-TTK

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000045754 hTTK/Phos:1
Example: UniProtKB:P33981-1, Thr-676, MOD:00047		 acts_upstream_of_or_withinGO:0046777 protein autophosphorylation PMID:18680479; PMID:19120698
GO:0051298 centrosome duplication PMID:17728254
GO:0071174 mitotic spindle checkpoint signaling PMID:18083840
enablesGO:0004672 protein kinase activity PMID:18680479
PR:000049844 hTTK/(Act-loop)Phos+
Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)		 acts_upstream_of_or_withinGO:0046777 protein autophosphorylation PMID:18680479; PMID:19120698
enablesGO:0004672 protein kinase activity PMID:18680479; PMID:19120698
PR:000049845 hTTK/(Act-loop_P+1-loop)Phos+
Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047		 enablesGO:0004672 protein kinase activity PMID:19120698
PR:P33981 hTTK acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:20624902
GO:0032092 positive regulation of protein binding PMID:22660415
GO:0032092 positive regulation of protein binding PMID:22660415
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
GO:0045841 negative regulation of mitotic metaphase/anaphase transition PMID:20624902
GO:0051310 metaphase chromosome alignment PMID:20624902; PMID:22732840
enablesGO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-590746
located_inGO:0000776 kinetochore PMID:20624902
PR:P54199 yTTK acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:8688079
GO:0034501 protein localization to kinetochore PMID:22521787
GO:0034501 protein localization to kinetochore PMID:22521787
enablesGO:0004672 protein kinase activity PMID:22521787; PMID:8688079