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Documentation
Protein Ontology report - TGF-beta 1 proteolytic cleavage product
PR:000018292 -
http://purl.obolibrary.org/obo/PR_000018292
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000018292
PRO name
TGF-beta 1 proteolytic cleavage product
Synonyms
PRO-Short-label
:
EXACT:
TGFB1/ClvPrd
Definition
"A TGF-beta 1 that has been processed by proteolytic cleavage." [PRO:DNx]
PRO Category
modification
Parent
PR:000000182
TGF-beta 1
PR:000018264
proteolytic cleavage product
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
3
Organism-Modification
15
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
modification
PR:000018292
TGF-beta 1 proteolytic cleavage product
TGFB1/ClvPrd
modification
PR:000000616
TGF-beta 1 isoform 1 mature form
TGFB1/iso:1/mature
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
Yes
organism-modification
PR:000025929
TGF-beta 1 isoform 1 mature form (rat)
rTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
Yes
modification
PR:000000617
TGF-beta 1 isoform 1 latency associated peptide
TGFB1/iso:1/LAP
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
organism-modification
PR:000000619
TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
Yes
organism-modification
PR:000000620
TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
Yes
organism-modification
PR:000000621
TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification
PR:000000622
TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
organism-modification
PR:000000623
TGF-beta 1 sequence variant H222D cleaved 1 (human)
hTGFB1/var:H222D/Clv:1
Yes
organism-modification
PR:000000624
TGF-beta 1 sequence variant H222D cleaved 2 (human)
hTGFB1/var:H222D/Clv:2
Yes
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
Yes
organism-modification
PR:000000627
TGF-beta 1 sequence variant R218H cleaved 1 (human)
hTGFB1/var:R218H/Clv:1
Yes
organism-modification
PR:000000628
TGF-beta 1 sequence variant R218H cleaved 2 (human)
hTGFB1/var:R218H/Clv:2
Yes
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TGFB1/ClvPrd
forms found in complexes
TGFB1/ClvPrd
Component
Complexes
PR:000000616
TGFB1/iso:1/mature
PR:000025925
dimeric TGF-beta 1
PR:000025927
hTGFB1/iso:1/mature
PR:000025926
dimeric TGF-beta 1 (human)
PR:000025929
rTGFB1/iso:1/mature
PR:000025931
dimeric TGF-beta 1 (rat)
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179
transforming growth factor beta receptor signaling pathway
PR:000000621
hTGFB1/var:R218C/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000623
hTGFB1/var:H222D/Clv:1
PMID:12493741
PR:000000627
hTGFB1/var:R218H/Clv:1
PMID:11278244
PR:000025927
hTGFB1/iso:1/mature
PMID:8471846
PR:000025930
GrMonkey-TGFB1/iso:1/mature
PMID:3185545
GO:0030879
mammary gland development
PR:000025928
mTGFB1/iso:1/mature
PMID:1821856
GO:0043066
negative regulation of apoptotic process
PR:000000623
hTGFB1/var:H222D/Clv:1
PMID:12493741
PR:000025927
hTGFB1/iso:1/mature
PMID:9918798
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005160
transforming growth factor beta receptor binding
PR:000000621
hTGFB1/var:R218C/Clv:1
PMID:11278244
PR:000000627
hTGFB1/var:R218H/Clv:1
PMID:11278244
PR:000025928
mTGFB1/iso:1/mature
PMID:14764882
GO:0008083
growth factor activity
PR:000000621
hTGFB1/var:R218C/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000623
hTGFB1/var:H222D/Clv:1
PMID:12493741
PR:000000625
hTGFB1/var:C225R/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000627
hTGFB1/var:R218H/Clv:1
PMID:12493741
;
PMID:12843182
GO:0042803
protein homodimerization activity
PR:000000621
hTGFB1/var:R218C/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000627
hTGFB1/var:R218H/Clv:1
PMID:11278244
PR:000025927
hTGFB1/iso:1/mature
PMID:3162913
;
PMID:8471846
PR:000025930
GrMonkey-TGFB1/iso:1/mature
PMID:3185545
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615
extracellular space
PR:000000620
hTGFB1/var:T81H/Clv:2
PMID:12493741
PR:000000621
hTGFB1/var:R218C/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000623
hTGFB1/var:H222D/Clv:1
PMID:12493741
PR:000000625
hTGFB1/var:C225R/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000627
hTGFB1/var:R218H/Clv:1
PMID:11278244
GO:0031012
extracellular matrix
PR:000025927
hTGFB1/iso:1/mature
PMID:8294500
PR:000025928
mTGFB1/iso:1/mature
PMID:9008713
PR:000025929
rTGFB1/iso:1/mature
PMID:11907708
PR:000025930
GrMonkey-TGFB1/iso:1/mature
PMID:3185545
GO:0032991
protein-containing complex
PR:000036526
hTGFB1/iso:1/LAP
PMID:17015622
;
PMID:3162913
SO:0001558
polypeptide_localization_variant
PR:000000619
hTGFB1/var:T81H/Clv:1
PMID:12493741
SO:0001561
polypeptide_partial_loss_of_function
PR:000000622
hTGFB1/var:R218C/Clv:2
PMID:11278244
PR:000000624
hTGFB1/var:H222D/Clv:2
PMID:11278244
PR:000000626
hTGFB1/var:C225R/Clv:2
PMID:11278244
PR:000000628
hTGFB1/var:R218H/Clv:2
PMID:11278244
SO:0001601
conformational_change_variant
PR:000000624
hTGFB1/var:H222D/Clv:2
PMID:11278244
PR:000000628
hTGFB1/var:R218H/Clv:2
PMID:11278244
