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Protein Ontology report - TGF-beta 1 proteolytic cleavage product

PR:000018292 - http://purl.obolibrary.org/obo/PR_000018292

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Ontology Information

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PRO ID

PR:000018292

PRO name

TGF-beta 1 proteolytic cleavage product

Synonyms

PRO-Short-label:

EXACT:

TGFB1/ClvPrd

Definition

"A TGF-beta 1 that has been processed by proteolytic cleavage." [PRO:DNx]

PRO Category

modification

Parent

PR:000000182 TGF-beta 1
PR:000018264 proteolytic cleavage product

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	3	Organism-Modification	15

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

modification

PR:000018292 TGF-beta 1 proteolytic cleavage product

TGFB1/ClvPrd

modification

PR:000000616 TGF-beta 1 isoform 1 mature form

TGFB1/iso:1/mature

organism-modification

PR:000025927 TGF-beta 1 isoform 1 mature form (human)

hTGFB1/iso:1/mature

organism-modification

PR:000025928 TGF-beta 1 isoform 1 mature form (mouse)

mTGFB1/iso:1/mature

organism-modification

PR:000025929 TGF-beta 1 isoform 1 mature form (rat)

rTGFB1/iso:1/mature

organism-modification

PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey)

GrMonkey-TGFB1/iso:1/mature

modification

PR:000000617 TGF-beta 1 isoform 1 latency associated peptide

TGFB1/iso:1/LAP

organism-modification

PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP

organism-modification

PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human)

hTGFB1/var:T81H/Clv:1

organism-modification

PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human)

hTGFB1/var:T81H/Clv:2

organism-modification

PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human)

hTGFB1/var:R218C/Clv:1

organism-modification

PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human)

hTGFB1/var:R218C/Clv:2

organism-modification

PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human)

hTGFB1/var:H222D/Clv:1

organism-modification

PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human)

hTGFB1/var:H222D/Clv:2

organism-modification

PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human)

hTGFB1/var:C225R/Clv:1

organism-modification

PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human)

hTGFB1/var:C225R/Clv:2

organism-modification

PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human)

hTGFB1/var:R218H/Clv:1

organism-modification

PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human)

hTGFB1/var:R218H/Clv:2

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TGFB1/ClvPrd forms found in complexes

TGFB1/ClvPrd Component	Complexes
PR:000000616 TGFB1/iso:1/mature	PR:000025925 dimeric TGF-beta 1
PR:000025927 hTGFB1/iso:1/mature	PR:000025926 dimeric TGF-beta 1 (human)
PR:000025929 rTGFB1/iso:1/mature	PR:000025931 dimeric TGF-beta 1 (rat)

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000619 hTGFB1/var:T81H/Clv:1 UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979	located_in	SO:0001558 polypeptide_localization_variant	PMID:12493741
PR:000000620 hTGFB1/var:T81H/Clv:2 UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979	located_in	GO:0005615 extracellular space	PMID:12493741
PR:000000621 hTGFB1/var:R218C/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11062463; PMID:12493741; PMID:12843182
	enables	GO:0005160 transforming growth factor beta receptor binding	PMID:11278244
		increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:11062463; PMID:12493741; PMID:12843182
		GO:0042803 protein homodimerization activity	PMID:11062463; PMID:12493741; PMID:12843182
	located_in	GO:0005615 extracellular space	PMID:11062463; PMID:12493741; PMID:12843182
PR:000000622 hTGFB1/var:R218C/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
PR:000000623 hTGFB1/var:H222D/Clv:1 UniProtKB:P01137, 279-390, His-222, CHEBI:29958	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:12493741
	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	PMID:12493741
	enables	increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:12493741
	located_in	GO:0005615 extracellular space	PMID:12493741
PR:000000624 hTGFB1/var:H222D/Clv:2 UniProtKB:P01137, 30-278, His-222, CHEBI:29958	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
	located_in	SO:0001601 conformational_change_variant	PMID:11278244
PR:000000625 hTGFB1/var:C225R/Clv:1 UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952	enables	increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:11062463; PMID:12493741; PMID:12843182
	located_in	GO:0005615 extracellular space	PMID:11062463; PMID:12493741; PMID:12843182
PR:000000626 hTGFB1/var:C225R/Clv:2 UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
PR:000000627 hTGFB1/var:R218H/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11278244
	enables	GO:0005160 transforming growth factor beta receptor binding	PMID:11278244
		increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:12493741; PMID:12843182
		GO:0042803 protein homodimerization activity	PMID:11278244
	located_in	GO:0005615 extracellular space	PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
	located_in	SO:0001601 conformational_change_variant	PMID:11278244
PR:000025927 hTGFB1/iso:1/mature UniProtKB:P01137-1, 279-390	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:8471846
	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	PMID:9918798
	enables	GO:0042803 protein homodimerization activity	PMID:3162913; PMID:8471846
	located_in	GO:0031012 extracellular matrix	PMID:8294500
PR:000025928 mTGFB1/iso:1/mature UniProtKB:P04202-1, 279-390	acts_upstream_of_or_within	GO:0030879 mammary gland development	PMID:1821856
	enables	GO:0005160 transforming growth factor beta receptor binding	PMID:14764882
	located_in	GO:0031012 extracellular matrix	PMID:9008713
PR:000025929 rTGFB1/iso:1/mature UniProtKB:P17246-1, 279-390	located_in	GO:0031012 extracellular matrix	PMID:11907708
PR:000025930 GrMonkey-TGFB1/iso:1/mature UniProtKB:P09533-1, 279-390	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:3185545
	enables	GO:0042803 protein homodimerization activity	PMID:3185545
	located_in	GO:0031012 extracellular matrix	PMID:3185545
PR:000036526 hTGFB1/iso:1/LAP UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160	located_in	GO:0032991 protein-containing complex	PMID:17015622; PMID:3162913