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Protein Ontology report - TGF-beta 3 proteolytic cleavage product
PR:000018294 - http://purl.obolibrary.org/obo/PR_000018294
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000018294   
  PRO nameTGF-beta 3 proteolytic cleavage product 
  Synonyms
PRO-Short-label: EXACT:TGFB3/ClvPrd
  Definition"A TGF-beta 3 that has been processed by proteolytic cleavage." [PRO:DNx] 
  PRO Categorymodification 
  ParentPR:000000184 TGF-beta 3
PR:000018264 proteolytic cleavage product
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification4                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
modification



PR:000018294

TGF-beta 3 proteolytic cleavage product

TGFB3/ClvPrd


"A TGF-beta 3 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000634

TGF-beta 3 isoform 1 cleaved 1

TGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature peptide." [PRO:CNA]


organism-modification



PR:000036536

TGF-beta 3 isoform 1 cleaved 1 (human)

hTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in human. UniProtKB:P10600-1, 301-412." [PMID:18243111, PRO:CNA]

Yes

organism-modification



PR:000036537

TGF-beta 3 isoform 1 cleaved 1 (mouse)

mTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in mouse. UniProtKB:P17125-1, 299-410." [PMID:1821856, PRO:CNA]

Yes

modification



PR:000000635

TGF-beta 3 isoform 1 cleaved 2

TGFB3/iso:1/Clv:2


"A TGF-beta 3 isoform 1, signal peptide removed form that has been processed by proteolytic cleavage to remove the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP)." [PMID:11821050]


modification



PR:000000636

TGF-beta 3 isoform 1 cleaved 3

TGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PRO:CNA]


organism-modification



PR:000036538

TGF-beta 3 isoform 1 cleaved 3 (mouse)

mTGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1 cleaved 3 in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P17125-1, 30-298, 299-410." [PMID:1821856, PRO:CNA, PRO:DAN]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0030879 mammary gland developmentPR:000036537 mTGFB3/iso:1/Clv:1 PMID:1821856
PR:000036538 mTGFB3/iso:1/Clv:3 PMID:1821856

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005160 transforming growth factor beta receptor bindingPR:000036536 hTGFB3/iso:1/Clv:1 PMID:18243111
GO:0042803 protein homodimerization activityPR:000036536 hTGFB3/iso:1/Clv:1 PMID:18243111