Home
|
Linked Open Data
|
Browse
|
Search
|
Statistics
|
Download
RACE-PRO
PRO tracker
Community
PRO Consortium
Publications
Documentation
Protein Ontology report - TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
PR:000021904 -
http://purl.obolibrary.org/obo/PR_000021904
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000021904
PRO name
TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFB1/var:R218C/SigPep-
PRO-proteoform-std
:
EXACT:
UniProtKB:P01137
, 30-390, Arg-218,
CHEBI:29950
Other
:
EXACT:
TGF-beta 1 sequence variant 3, signal peptide removed form (human)
Definition
"A TGF-beta 1 sequence variant R218C (human) that has had the signal peptide removed.
UniProtKB:P01137
, 30-390, Arg-218,
CHEBI:29950
." [PRO:DAN]
PRO Category
organism-modification
Parent
PR:000000400
TGF-beta 1 sequence variant R218C (human)
PR:000049430
transforming growth factor beta-1, signal peptide removed form (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
Back to top
Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
organism-modification
PR:000021904
TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
hTGFB1/var:R218C/SigPep-
organism-modification
PR:000000621
TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification
PR:000000622
TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
Back to top
Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000621
hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11062463
;
PMID:12493741
;
PMID:12843182
enables
GO:0005160
transforming growth factor beta receptor binding
PMID:11278244
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:11062463
;
PMID:12493741
;
PMID:12843182
GO:0042803
protein homodimerization activity
PMID:11062463
;
PMID:12493741
;
PMID:12843182
located_in
GO:0005615
extracellular space
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000622
hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
