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Protein Ontology report - neurotrophin
PR:000021998 - http://purl.obolibrary.org/obo/PR_000021998
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000021998   
  PRO nameneurotrophin 
  Definition"A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain." [PMID:10388563
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 14                                        
         Sequence3                                                  Organism-Sequence 14                                        
         Modification6                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF001789
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
family



PR:000021998

neurotrophin

MAP2K4/Phos:1


"A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain." [PMID:10388563]


gene



PR:000004716

brain-derived neurotrophic factor

BDNF


"A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P21237

brain-derived neurotrophic factor (mouse)

mBDNF


"A brain-derived neurotrophic factor that is encoded in the genome of mouse." [OMA:P21237, PRO:DNx]


organism-sequence



PR:P21237-1

brain-derived neurotrophic factor isoform 1 (mouse)

mBDNF/iso:1


"A brain-derived neurotrophic factor isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P21237-2

brain-derived neurotrophic factor isoform m2 (mouse)

mBDNF/iso:m2


"A brain-derived neurotrophic factor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21237-2." [PRO:DNx, UniProtKB:P21237]


organism-gene



PR:P23363

brain-derived neurotrophic factor (rat)

rBDNF


"A brain-derived neurotrophic factor that is encoded in the genome of rat." [OMA:P23363, PRO:DNx]


organism-sequence



PR:P23363-1

brain-derived neurotrophic factor isoform 1 (rat)

rBDNF/iso:1


"A brain-derived neurotrophic factor isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P23560

brain-derived neurotrophic factor (human)

hBDNF


"A brain-derived neurotrophic factor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P23560]


organism-sequence



PR:P23560-1

brain-derived neurotrophic factor isoform h1 (human)

hBDNF/iso:h1


"A brain-derived neurotrophic factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23560-1." [PRO:DNx, UniProtKB:P23560]


organism-sequence



PR:P23560-2

brain-derived neurotrophic factor isoform h2 (human)

hBDNF/iso:h2


"A brain-derived neurotrophic factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23560-2." [PRO:DNx, UniProtKB:P23560]


organism-sequence



PR:P23560-3

brain-derived neurotrophic factor isoform h3 (human)

hBDNF/iso:h3


"A brain-derived neurotrophic factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23560-3." [PRO:DNx, UniProtKB:P23560]


organism-sequence



PR:P23560-4

brain-derived neurotrophic factor isoform h4 (human)

hBDNF/iso:h4


"A brain-derived neurotrophic factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23560-4." [PRO:DNx, UniProtKB:P23560]


organism-sequence



PR:P23560-5

brain-derived neurotrophic factor isoform h5 (human)

hBDNF/iso:h5


"A brain-derived neurotrophic factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23560-5." [PRO:DNx, UniProtKB:P23560]


organism-gene



PR:P25429

brain-derived neurotrophic factor (chicken)

chick-BDNF


"A brain-derived neurotrophic factor that is encoded in the genome of chicken." [OMA:P25429, PRO:DNx]


sequence



PR:000039045

brain-derived neurotrophic factor isoform 1

BDNF/iso:1


"A brain-derived neurotrophic factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21237-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P21237-1

brain-derived neurotrophic factor isoform 1 (mouse)

mBDNF/iso:1


"A brain-derived neurotrophic factor isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P23363-1

brain-derived neurotrophic factor isoform 1 (rat)

rBDNF/iso:1


"A brain-derived neurotrophic factor isoform 1 that is encoded in the genome of rat." [PRO:DNx]


modification



PR:000019130

brain-derived neurotrophic factor proteolytic cleavage product

BDNF/ClvPrd


"A brain-derived neurotrophic factor that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000011194

beta-nerve growth factor

NGF


"A neurotrophin that is a translation product of the human NGF gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P01138

beta-nerve growth factor (human)

hNGF


"A beta-nerve growth factor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01138]


organism-sequence



PR:P01138-1

beta-nerve growth factor isoform 1 (human)

hNGF/iso:1


"A beta-nerve growth factor isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026817

beta-nerve growth factor isoform 1 cleaved 1 (human)

hNGF/iso:1/Clv:1


"A beta-nerve growth factor isoform 1 cleaved 1 in human. This form is the mature protein. UniProtKB:P01138-1, 122-241." [PRO:DNx, UniProtKB:P01138]


organism-modification



PR:000048601

beta-nerve growth factor, signal peptide removed form (human)

hNGF/SigPep-


"A beta-nerve growth factor (human) that has had the signal peptide removed. UniProtKB:P01138, 19-241." [PRO:DNx, Reactome:R-HSA-187033, Reactome:R-HSA-187036, Reactome:R-HSA-187047]


organism-modification



PR:000026817

beta-nerve growth factor isoform 1 cleaved 1 (human)

hNGF/iso:1/Clv:1


"A beta-nerve growth factor isoform 1 cleaved 1 in human. This form is the mature protein. UniProtKB:P01138-1, 122-241." [PRO:DNx, UniProtKB:P01138]


organism-gene



PR:P01139

beta-nerve growth factor (mouse)

mNGF


"A beta-nerve growth factor that is encoded in the genome of mouse." [OMA:P01139, PRO:DNx]


organism-sequence



PR:P01139-1

beta-nerve growth factor isoform 1 (mouse)

mNGF/iso:1


"A beta-nerve growth factor isoform 1 that is encoded in the genome of mouse." [PRO:CNx]


organism-gene



PR:P25427

beta-nerve growth factor (rat)

rNGF


"A beta-nerve growth factor that is encoded in the genome of rat." [OMA:P25427, PRO:DNx]


sequence



PR:000026814

beta-nerve growth factor isoform 1

NGF/iso:1


"A beta-nerve growth factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01138-1 or a 1:1 ortholog thereof." [PRO:CNx]


organism-sequence



PR:P01138-1

beta-nerve growth factor isoform 1 (human)

hNGF/iso:1


"A beta-nerve growth factor isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026817

beta-nerve growth factor isoform 1 cleaved 1 (human)

hNGF/iso:1/Clv:1


"A beta-nerve growth factor isoform 1 cleaved 1 in human. This form is the mature protein. UniProtKB:P01138-1, 122-241." [PRO:DNx, UniProtKB:P01138]


organism-sequence



PR:P01139-1

beta-nerve growth factor isoform 1 (mouse)

mNGF/iso:1


"A beta-nerve growth factor isoform 1 that is encoded in the genome of mouse." [PRO:CNx]


modification



PR:000026818

beta-nerve growth factor isoform 1, signal peptide removed form

NGF/iso:1/SigPep-


"A beta-nerve growth factor isoform 1 that has had the signal peptide removed." [PRO:CNx]


modification



PR:000026816

beta-nerve growth factor isoform 1 cleaved 1

NGF/iso:1/Clv:1


"A beta-nerve growth factor isoform 1, signal peptide removed form that has had the propeptide removed, yielding the mature protein. Example: UniProtKB:P01138-1, 122-241." [PRO:CNx]


organism-modification



PR:000026817

beta-nerve growth factor isoform 1 cleaved 1 (human)

hNGF/iso:1/Clv:1


"A beta-nerve growth factor isoform 1 cleaved 1 in human. This form is the mature protein. UniProtKB:P01138-1, 122-241." [PRO:DNx, UniProtKB:P01138]


modification



PR:000020737

beta-nerve growth factor proteolytic cleavage product

NGF/ClvPrd


"A beta-nerve growth factor that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000011459

neurotrophin-3

NTF3


"A neurotrophin that is a translation product of the human NTF3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P18280

neurotrophin-3 (rat)

rNTF3


"A neurotrophin-3 that is encoded in the genome of rat." [OMA:P18280, PRO:DNx]


organism-gene



PR:P20181

neurotrophin-3 (mouse)

mNTF3


"A neurotrophin-3 that is encoded in the genome of mouse." [OMA:P20181, PRO:DNx]


organism-gene



PR:P20783

neurotrophin-3 (human)

hNTF3


"A neurotrophin-3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P20783]


organism-sequence



PR:P20783-1

neurotrophin-3 isoform h1 (human)

hNTF3/iso:h1


"A neurotrophin-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20783-1." [PRO:DNx, UniProtKB:P20783]


organism-sequence



PR:P20783-2

neurotrophin-3 isoform h2 (human)

hNTF3/iso:h2


"A neurotrophin-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20783-2." [PRO:DNx, UniProtKB:P20783]


organism-gene



PR:P25433

neurotrophin-3 (chicken)

chick-NTF3


"A neurotrophin-3 that is encoded in the genome of chicken." [OMA:P25433, PRO:DNx]


modification



PR:000020795

neurotrophin-3 proteolytic cleavage product

NTF3/ClvPrd


"A neurotrophin-3 that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000011460

neurotrophin-4

NTF4


"A neurotrophin that is a translation product of the human NTF4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P34130

neurotrophin-4 (human)

hNTF4


"A neurotrophin-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P34130]


organism-gene



PR:P34131

neurotrophin-4 (rat)

rNTF4


"A neurotrophin-4 that is encoded in the genome of rat." [OMA:P34131, PRO:DNx]


organism-sequence



PR:P34131-1

neurotrophin-4 isoform 1 (rat)

rNTF4/iso:1


"A neurotrophin-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q80VU4

neurotrophin-4 (mouse)

mNTF4


"A neurotrophin-4 that is encoded in the genome of mouse." [OMA:Q80VU4, PRO:DNx]


organism-sequence



PR:Q80VU4-1

neurotrophin-4 isoform 1 (mouse)

mNTF4/iso:1


"A neurotrophin-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000041452

neurotrophin-4 isoform 1

NTF4/iso:1


"A neurotrophin-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80VU4-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P34131-1

neurotrophin-4 isoform 1 (rat)

rNTF4/iso:1


"A neurotrophin-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q80VU4-1

neurotrophin-4 isoform 1 (mouse)

mNTF4/iso:1


"A neurotrophin-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


modification



PR:000020796

neurotrophin-4 proteolytic cleavage product

NTF4/ClvPrd


"A neurotrophin-4 that has been processed by proteolytic cleavage." [PRO:DNx]