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Protein Ontology report - precursor of amyloid-beta precursor protein gamma-secretase C-terminal fragment
PR:000025744 - http://purl.obolibrary.org/obo/PR_000025744
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000025744   
  PRO nameprecursor of amyloid-beta precursor protein gamma-secretase C-terminal fragment 
  Synonyms
PRO-Short-label: EXACT:APP-preCTF
  Definition"An amyloid-beta precursor protein proteolytic cleavage product that gives rise to gamma secretase C-terminal fragments 50, 57, and 59." [PRO:DAN] 
  CommentRequested by=Alzforum. 
  PRO Categorymodification 
  ParentPR:000019036 amyloid-beta precursor protein proteolytic cleavage product
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification11                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
modification



PR:000025744

precursor of amyloid-beta precursor protein gamma-secretase C-terminal fragment

APP-preCTF


"An amyloid-beta precursor protein proteolytic cleavage product that gives rise to gamma secretase C-terminal fragments 50, 57, and 59." [PRO:DAN]


modification



PR:000025580

C99

APP-C99


"An amyloid-beta precursor protein proteolytic cleavage product that is the C-terminal product of cleavage by beta-secretase of certain amyloid-beta precursor protein isoforms, signal peptide removed form. Example: UniProtKB:P05067-1, 672-770." [PRO:DAN]


modification



PR:000036193

amyloid beta peptide

Abeta


"An amyloid-beta precursor protein proteolytic cleavage product that is the N-terminal chain produced by gamma-secretase cleavage of C99." [PMID:19828817, PRO:DAN]


modification



PR:000025584

beta-amyloid protein 40

Abeta(1-40)


"An amyloid beta peptide that corresponds to residues 1-40 of C99. Example: UniProtKB:P05067-1, 672-711." [PRO:DAN]


organism-modification



PR:000050064

beta-amyloid protein 40 (human)

hAbeta(1-40)


"A beta-amyloid protein 40 in human. Example: UniProtKB:P05067-1, 672-711." [PRO:DAN]


organism-modification



PR:000085741

beta-amyloid protein 40 (mouse)

mAbeta(1-40)


"A beta-amyloid protein 40 in mouse. Example: UniProtKB:P12023-1, 672-711." [PRO:DAN]


modification



PR:000025583

beta-amyloid protein 42

Abeta(1-42)


"An amyloid beta peptide that corresponds residues 1-42 of C99. Example: UniProtKB:P05067-1, 672-713." [PRO:DAN]


organism-modification



PR:000050063

beta-amyloid protein 42 (human)

hAbeta(1-42)


"A beta-amyloid protein 42 in human. Example: UniProtKB:P05067-1, 672-713." [PRO:DAN]


modification



PR:000025581

C83

APP-C83


"An amyloid-beta precursor protein proteolytic cleavage product that is the C-terminal product of cleavage by alpha-secretase of certain amyloid-beta precursor protein isoforms, signal peptide removed form. Example: UniProtKB:P05067-1, 688-770." [PRO:DAN]


modification



PR:000025588

P3(40)

APP-P3(40)


"An amyloid-beta precursor protein proteolytic cleavage product that is the N-terminal chain of 24 amino acid residues produced by gamma-secretase cleavage of C83." [PRO:DAN]


modification



PR:000025587

P3(42)

APP-P3(42)


"An amyloid-beta precursor protein proteolytic cleavage product that is the N-terminal chain of 26 amino acid residues produced by gamma-secretase cleavage of C83." [PRO:DAN]


modification



PR:000025585

gamma-secretase C-terminal fragment 57

APP-CTF(57)


"An amyloid-beta precursor protein proteolytic cleavage product that is the C-terminal chain of 57 amino acid residues produced by gamma-secretase cleavage of certain amyloid-beta A4 proteolytic cleavage products. Example: UniProtKB:P05067-1, 714-770." [PRO:DAN]


modification



PR:000025586

gamma-secretase C-terminal fragment 59

APP-CTF(59)


"An amyloid-beta precursor protein proteolytic cleavage product that is the C-terminal chain of 59 amino acid residues produced by gamma-secretase cleavage of certain amyloid-beta A4 proteolytic cleavage products. Example: UniProtKB:P05067-1, 712-770." [PRO:DAN]


modification



PR:000025589

gamma-secretase C-terminal fragment 50

APP-CTF(50)


"An amyloid-beta precursor protein proteolytic cleavage product that is the C-terminal chain of 50 amino acid residues produced by gamma-secretase cleavage of certain amyloid-beta A4 proteolytic cleavage products. Example: UniProtKB:P05067-1, 721-770." [PRO:DAN]