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Protein Ontology report - MYD88:TIRAP:activated TLR complex
PR:000025774 -
http://purl.obolibrary.org/obo/PR_000025774
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000025774
PRO name
MYD88:TIRAP:activated TLR complex
Synonyms
Other
:
EXACT:
MyD88:Mal:activated TLR complex | MyD88:TIRAP complexed with the activated TLR receptor
Definition
"A protein-containing complex that is composed of MyD88, Mal/TIRAP and an activated Toll-like receptor (TLR). Mammalian TLRs function as sensors of infection and induce the activation of innate and adaptive immune responses. Upon recognizing conserved pathogen-associated molecular products, TLRs activate host defence responses through their intracellular signalling domain, the Toll/interleukin-1 receptor (TIR) domain, and the downstream adaptor protein MyD88. Mal/TIRAP is differentially involved in signalling by members of the TLR family and may account for specificity in the downstream signalling of individual TLRs." [
PMID:12447441
,
PMID:12447442
,
PMID:12888566
]
PRO Category
complex
Parent
G0043235
receptor complex
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Complex
3
Organism-Complex
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
complex
PR:000025774
MYD88:TIRAP:activated TLR complex
h(LPSR:3)
"A protein-containing complex that is composed of MyD88, Mal/TIRAP and an activated Toll-like receptor (TLR). Mammalian TLRs function as sensors of infection and induce the activation of innate and adaptive immune responses. Upon recognizing conserved pathogen-associated molecular products, TLRs activate host defence responses through their intracellular signalling domain, the Toll/interleukin-1 receptor (TIR) domain, and the downstream adaptor protein MyD88. Mal/TIRAP is differentially involved in signalling by members of the TLR family and may account for specificity in the downstream signalling of individual TLRs." [PMID:12447441, PMID:12447442, PMID:12888566]
complex
PR:000025783
MYD88:TIRAP:activated TLR2 receptor
h(CD3E:CD3G)
"A MYD88:TIRAP:activated TLR complex whose activated TLR component is TLR2 receptor." [PRO:CNA]
complex
PR:000025784
MYD88:TIRAP:activated TLR4 receptor
h(CD3E:CD3G)
"A MYD88:TIRAP:activated TLR complex whose activated TLR component is TLR4 receptor." [PMID:16751103, PRO:CNA, PRO:DAN, TLR:AMM]
organism-complex
PR:000027174
MYD88s:TIRAP:activated TLR4 receptor (mouse)
mTLR4/iso:1/SigPep-/NGlyco:1
"A MYD88:TIRAP:activated TLR4 receptor whose components are encoded in the genome of mouse. This complex contains the short isoform of MYD88." [PMID:12538665, TLR:AMM]
Yes
organism-complex
PR:000027175
MYD88l:TIRAP:activated TLR4 receptor (mouse)
mTLR4/iso:1/SigPep-/NGlyco:1
"A MYD88:TIRAP:activated TLR4 receptor whose components are encoded in the genome of mouse.This complex contains the long isoform of Myd88." [PMID:16751103, TLR:AMM]
organism-complex
PR:000037475
MYD88:TIRAP:activated TLR4 receptor (chicken)
chick-(MYD88:TIRAP:TLR4actv)
"A MYD88:TIRAP:activated TLR4 receptor whose components are encoded in the genome of chicken." [Reactome:R-GGA-433821]
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027174
mTLR4/iso:1/SigPep-/NGlyco:1
This complex contains the short isoform of MYD88
acts_upstream_of_or_within
GO:0034125
negative regulation of MyD88-dependent toll-like receptor signaling pathway
PMID:12538665
PR:000037475
chick-(MYD88:TIRAP:TLR4actv)
acts_upstream_of_or_within
GO:0002755
MyD88-dependent toll-like receptor signaling pathway
Reactome:REACT_25089
GO:0034142
toll-like receptor 4 signaling pathway
Reactome:REACT_25089
located_in
GO:0005886
plasma membrane
Reactome:REACT_26615
