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PRO ID
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| PRO name | MYD88:TIRAP:activated TLR complex |
| Synonyms | | Other: | EXACT: | MyD88:Mal:activated TLR complex | MyD88:TIRAP complexed with the activated TLR receptor | |
| Definition | "A protein-containing complex that is composed of MyD88, Mal/TIRAP and an activated Toll-like receptor (TLR). Mammalian TLRs function as sensors of infection and induce the activation of innate and adaptive immune responses. Upon recognizing conserved pathogen-associated molecular products, TLRs activate host defence responses through their intracellular signalling domain, the Toll/interleukin-1 receptor (TIR) domain, and the downstream adaptor protein MyD88. Mal/TIRAP is differentially involved in signalling by members of the TLR family and may account for specificity in the downstream signalling of individual TLRs." [PMID:12447441, PMID:12447442, PMID:12888566] |
| PRO Category | complex |
| Parent | G0043235 receptor complex
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| Terms by PRO Category |
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms | | Complex | 3 |
Organism-Complex |
3 | | | |
Term Hierarchy
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