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Protein Ontology report - 5-aminolevulinate synthase
PR:000026125 -
http://purl.obolibrary.org/obo/PR_000026125
Protein Forms
Ontology Information
Show OBO stanza
PRO ID
PR:000026125
PRO name
5-aminolevulinate synthase
Synonyms
Other
:
EXACT:
5-aminolevulinic acid synthase | ALAS
Definition
"A PLP-dependent alpha-oxoamine synthase whose functional form is the first enzyme in the pathway for synthesis of all tetrapyrroles in non-photosynthetic eukaryotes and alpha-proteobacteria. ALAS catalyzes the decarboxylative condensation of glycine and succinyl-CoA, yielding 5-aminolevulinic acid, free coenzyme-A and CO2." [
PMID:13598764
, PRO:CNA]
PRO Category
family
Parent
PR:000026124
PLP-dependent alpha-oxoamine synthase
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
1
Organism-Family
0
Gene
2
Organism-Gene
11
Sequence
2
Organism-Sequence
10
Modification
2
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF000444
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
family
PR:000026125
5-aminolevulinate synthase
hMCCC2/var:MCCB IVS3+5G->T
"A PLP-dependent alpha-oxoamine synthase whose functional form is the first enzyme in the pathway for synthesis of all tetrapyrroles in non-photosynthetic eukaryotes and alpha-proteobacteria. ALAS catalyzes the decarboxylative condensation of glycine and succinyl-CoA, yielding 5-aminolevulinic acid, free coenzyme-A and CO2." [PMID:13598764, PRO:CNA]
gene
PR:000003916
5-aminolevulinate synthase, non-specific, mitochondrial
ALAS1
"A 5-aminolevulinate synthase that is a translation product of the human ALAS1 gene or a 1:1 ortholog thereof." [PRO:CNA]
organism-gene
PR:P07997
5-aminolevulinate synthase, non-specific, mitochondrial (chicken)
chick-ALAS1
"A 5-aminolevulinate synthase, non-specific, mitochondrial that is encoded in the genome of chicken." [OMA:P07997, PRO:DNx]
organism-gene
PR:P13195
5-aminolevulinate synthase, non-specific, mitochondrial (rat)
rALAS1
"A 5-aminolevulinate synthase, non-specific, mitochondrial that is encoded in the genome of rat." [OMA:P13195, PRO:DNx]
organism-sequence
PR:P13195-1
5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (rat)
rALAS1/iso:1
"A 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 that is encoded in the genome of rat." [PRO:DNx]
organism-gene
PR:P13196
5-aminolevulinate synthase, non-specific, mitochondrial (human)
hALAS1
"A 5-aminolevulinate synthase, non-specific, mitochondrial that is encoded in the genome of human." [PRO:CNA, UniProtKB:P13196]
organism-sequence
PR:P13196-1
5-aminolevulinate synthase, non-specific, mitochondrial isoform h1 (human)
hALAS1/iso:h1
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13196-1." [PRO:DNx, UniProtKB:P13196]
organism-sequence
PR:P13196-2
5-aminolevulinate synthase, non-specific, mitochondrial isoform h2 (human)
hALAS1/iso:h2
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13196-2." [PRO:DNx, UniProtKB:P13196]
organism-modification
PR:000046304
5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed form (human)
hALAS1/TransPep-
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P13196, 57-640." [PRO:DNx, Reactome:R-HSA-189438]
organism-modification
PR:000046305
5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine form (human)
hALAS1/TransPep-/PyrdoxLys+
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that has had the transit peptide removed and that includes at least one pyridoxal phosphate lysine. UniProtKB:P13196, 57-640, MOD:00128." [PRO:DNx, Reactome:R-HSA-1022086]
organism-modification
PR:000046305
5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine form (human)
hALAS1/TransPep-/PyrdoxLys+
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that has had the transit peptide removed and that includes at least one pyridoxal phosphate lysine. UniProtKB:P13196, 57-640, MOD:00128." [PRO:DNx, Reactome:R-HSA-1022086]
organism-modification
PR:000066761
5-aminolevulinate synthase, non-specific, mitochondrial methylated 1 (human)
hALAS1/Me:1
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that has been methylated on the residue at the position equivalent to Cys-330 of the amino acid sequence represented by UniProtKB:P13196-1. Example: UniProtKB:P13196-1, Cys-330, MOD:00660." [IEDB_epitope:1025520, IEDB_epitope:999994, PRO:DNx]
organism-modification
PR:000078022
5-aminolevulinate synthase, non-specific, mitochondrial methylated 2 (human)
hALAS1/Me:2
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that has been methylated on the residue at the position equivalent to Cys-544 of the amino acid sequence represented by UniProtKB:P13196-1. Example: UniProtKB:P13196-1, Cys-544, MOD:00660." [IEDB_epitope:1009891, PRO:DNx]
organism-gene
PR:Q8VC19
5-aminolevulinate synthase, non-specific, mitochondrial (mouse)
mALAS1
"A 5-aminolevulinate synthase, non-specific, mitochondrial that is encoded in the genome of mouse." [OMA:Q8VC19, PRO:DNx]
organism-sequence
PR:Q8VC19-1
5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (mouse)
mALAS1/iso:1
"A 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
sequence
PR:000042113
5-aminolevulinate synthase, non-specific, mitochondrial isoform 1
ALAS1/iso:1
"A 5-aminolevulinate synthase, non-specific, mitochondrial that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VC19-1 or a 1:1 ortholog thereof." [PRO:DNx]
organism-sequence
PR:P13195-1
5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (rat)
rALAS1/iso:1
"A 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 that is encoded in the genome of rat." [PRO:DNx]
organism-sequence
PR:Q8VC19-1
5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (mouse)
mALAS1/iso:1
"A 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
modification
PR:000018945
5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed form
ALAS1/TransPep-
"A 5-aminolevulinate synthase, non-specific, mitochondrial that has had the transit peptide removed." [PRO:DNx]
organism-modification
PR:000046304
5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed form (human)
hALAS1/TransPep-
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P13196, 57-640." [PRO:DNx, Reactome:R-HSA-189438]
organism-modification
PR:000046305
5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine form (human)
hALAS1/TransPep-/PyrdoxLys+
"A 5-aminolevulinate synthase, non-specific, mitochondrial (human) that has had the transit peptide removed and that includes at least one pyridoxal phosphate lysine. UniProtKB:P13196, 57-640, MOD:00128." [PRO:DNx, Reactome:R-HSA-1022086]
gene
PR:000003917
5-aminolevulinate synthase, erythroid-specific, mitochondrial
ALAS2
"A 5-aminolevulinate synthase that is a translation product of the human ALAS2 gene or a 1:1 ortholog thereof." [PRO:CNA]
organism-gene
PR:O14092
5-aminolevulinate synthase, mitochondrial (Schizosaccharomyces pombe 972h-)
Spom972h-ALAS2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O14092, PRO:DNx]
organism-gene
PR:P08680
5-aminolevulinate synthase, erythroid-specific, mitochondrial (mouse)
mALAS2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of mouse." [OMA:P08680, PRO:DNx]
organism-sequence
PR:P08680-1
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (mouse)
mALAS2/iso:1
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
organism-gene
PR:P09950
5-aminolevulinate synthase, mitochondrial (yeast)
yALAS2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of yeast." [OMA:P09950, PRO:DNx]
organism-gene
PR:P22557
5-aminolevulinate synthase, erythroid-specific, mitochondrial (human)
hALAS2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of human." [PRO:CNA, UniProtKB:P22557]
organism-sequence
PR:P22557-1
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (human)
hALAS2/iso:1
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
organism-sequence
PR:P22557-2
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform h2 (human)
hALAS2/iso:h2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22557-2." [PRO:DNx, UniProtKB:P22557]
organism-sequence
PR:P22557-3
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform h3 (human)
hALAS2/iso:h3
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22557-3." [PRO:DNx, UniProtKB:P22557]
organism-sequence
PR:P22557-4
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform h4 (human)
hALAS2/iso:h4
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22557-4." [PRO:DNx, UniProtKB:P22557]
organism-modification
PR:000046306
5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine form (human)
hALAS2/TransPep-/PyrdoxLys+
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial (human) that has had the transit peptide removed and that includes at least one pyridoxal phosphate lysine. UniProtKB:P22557, 50-587, MOD:00128." [PRO:DNx, Reactome:R-HSA-1022083]
organism-gene
PR:Q54UX3
5-aminolevulinate synthase (Dictyostelium discoideum)
Dicty-ALAS2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of Dictyostelium discoideum." [PANTHER:PTHR13693:SF7, PRO:DNx]
organism-gene
PR:Q63147
5-aminolevulinate synthase, erythroid-specific, mitochondrial (rat)
rALAS2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of rat." [OMA:Q63147, PRO:DNx]
organism-sequence
PR:Q63147-1
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (rat)
rALAS2/iso:1
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 that is encoded in the genome of rat." [PRO:DNx]
organism-gene
PR:Q9YHT4
5-aminolevulinate synthase, erythroid-specific, mitochondrial (zebrafish)
z-ALAS2
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of zebrafish." [PRO:CNA]
sequence
PR:000039074
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1
ALAS2/iso:1
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22557-1 or a 1:1 ortholog thereof." [PRO:DNx]
organism-sequence
PR:P08680-1
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (mouse)
mALAS2/iso:1
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
organism-sequence
PR:P22557-1
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (human)
hALAS2/iso:1
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
organism-sequence
PR:Q63147-1
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (rat)
rALAS2/iso:1
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 that is encoded in the genome of rat." [PRO:DNx]
modification
PR:000018947
5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed form
ALAS2/TransPep-
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that has had the transit peptide removed." [PRO:DNx]
organism-modification
PR:000046306
5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine form (human)
hALAS2/TransPep-/PyrdoxLys+
"A 5-aminolevulinate synthase, erythroid-specific, mitochondrial (human) that has had the transit peptide removed and that includes at least one pyridoxal phosphate lysine. UniProtKB:P22557, 50-587, MOD:00128." [PRO:DNx, Reactome:R-HSA-1022083]
