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Protein Ontology report - eukaryotic serine palmitoyltransferase
PR:000026126 - http://purl.obolibrary.org/obo/PR_000026126
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000026126   
  PRO nameeukaryotic serine palmitoyltransferase 
  Synonyms
PRO-Short-label: EXACT:fam:euk-SPT
Other: SPT (BROAD)
  Definition"A PLP-dependent alpha-oxoamine synthase that is involved in sphingolipid biosynthesis in Eukaryota, particularly in the condensation of L-serine and palmitoyl-CoA." [PMID:12782147, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000026124 PLP-dependent alpha-oxoamine synthase
PR:000036194 eukaryotic protein
  TaxonNCBITaxon:2759 Eukaryota
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 13                                        
         Sequence2                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000026126 eukaryotic serine palmitoyltransferase
fam:euk-SPT

gene


PR:000015596 serine palmitoyltransferase 1
SPTLC1

organism-gene


PR:D4A2H2 serine palmitoyltransferase 1 (rat)
rSPTLC1

organism-gene


PR:O15269 serine palmitoyltransferase 1 (human)
hSPTLC1

Yes
organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human)
hSPTLC1/iso:1

organism-sequence


PR:O15269-2 serine palmitoyltransferase 1 isoform h2 (human)
hSPTLC1/iso:h2

organism-modification


PR:000045580 serine palmitoyltransferase 1 phosphorylated 1 (human)
hSPTLC1/Phos:1

organism-modification


PR:000061744 serine palmitoyltransferase 1 pyridoxal phosphate lysine form (human)
hSPTLC1/PyrdoxLys+

organism-modification


PR:000075626 serine palmitoyltransferase 1 cysteinylated 1 (human)
hSPTLC1/Cyst:1

organism-modification


PR:000078051 serine palmitoyltransferase 1 methylated 1 (human)
hSPTLC1/Me:1

organism-gene


PR:O35704 serine palmitoyltransferase 1 (mouse)
mSPTLC1
Yes
Yes
organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse)
mSPTLC1/iso:1
Yes
organism-gene


PR:O59682 serine palmitoyltransferase 1 (Schizosaccharomyces pombe 972h-)
Spom972h-SPTLC1

organism-gene


PR:P25045 serine palmitoyltransferase 1 (yeast)
ySPTLC1

organism-gene


PR:P91079 serine palmitoyltransferase 1 (worm)
SPTLC1 (worm)

organism-gene


PR:Q55FL5 serine palmitoyltransferase 1 (Dictyostelium discoideum)
Dicty-SPTLC1

organism-gene


PR:Q94IB8 long chain base biosynthesis protein 1 (Arabidopsis thaliana)
At-SPTLC1

sequence


PR:000022019 serine palmitoyltransferase 1 isoform 1
SPTLC1/iso:1

organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human)
hSPTLC1/iso:1

organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse)
mSPTLC1/iso:1
Yes
gene


PR:000015597 serine palmitoyltransferase 2
SPTLC2

organism-gene


PR:O15270 serine palmitoyltransferase 2 (human)
hSPTLC2

Yes
organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human)
hSPTLC2/iso:1

organism-modification


PR:000049342 serine palmitoyltransferase 2 pyridoxal phosphate lysine 1 (human)
hSPTLC2/Pyrdox:1

organism-modification


PR:000073274 serine palmitoyltransferase 2 methylated 1 (human)
hSPTLC2/Me:1

organism-modification


PR:000083083 serine palmitoyltransferase 2 methylated 2 (human)
hSPTLC2/Me:2

organism-gene


PR:P97363 serine palmitoyltransferase 2 (mouse)
mSPTLC2
Yes
Yes
organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse)
mSPTLC2/iso:1
Yes
organism-gene


PR:Q3B7D2 serine palmitoyltransferase 2 (rat)
rSPTLC2

sequence


PR:000022020 serine palmitoyltransferase 2 isoform 1
SPTLC2/iso:1

organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human)
hSPTLC2/iso:1

organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse)
mSPTLC2/iso:1
Yes
gene


PR:000015598 serine palmitoyltransferase 3
SPTLC3

organism-gene


PR:Q8BG54 serine palmitoyltransferase 3 (mouse)
mSPTLC3

Yes
organism-gene


PR:Q9NUV7 serine palmitoyltransferase 3 (human)
hSPTLC3

Yes
organism-sequence


PR:Q9NUV7-1 serine palmitoyltransferase 3 isoform h1 (human)
hSPTLC3/iso:h1

organism-sequence


PR:Q9NUV7-2 serine palmitoyltransferase 3 isoform h2 (human)
hSPTLC3/iso:h2

organism-modification


PR:000049343 serine palmitoyltransferase 3 pyridoxal phosphate lysine 1 (human)
hSPTLC3/Pyrdox:1

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fam:euk-SPT forms found in complexes   

fam:euk-SPT Component
 Complexes
PR:O15269 hSPTLC1 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O15270 hSPTLC2 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O35704 mSPTLC1 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:P97363 mSPTLC2 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:Q8BG54 mSPTLC3 PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:Q9NUV7 hSPTLC3 PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006686 sphingomyelin biosynthetic processPR:O35704 mSPTLC1 PMID:16216550
PR:P97363 mSPTLC2 PMID:16216550
GO:0046511 sphinganine biosynthetic processPR:O35704 mSPTLC1 PMID:19416652
PR:P97363-1 mSPTLC2/iso:1 PMID:9363775
GO:0046512 sphingosine biosynthetic processPR:O35704 mSPTLC1 PMID:16216550
PR:P97363 mSPTLC2 PMID:16216550
GO:0046513 ceramide biosynthetic processPR:O35704 mSPTLC1 PMID:16216550
PR:P97363 mSPTLC2 PMID:16216550

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004758 serine C-palmitoyltransferase activityPR:P97363-1 mSPTLC2/iso:1 PMID:9363775
NOT GO:0004758 serine C-palmitoyltransferase activityPR:O35704-1 mSPTLC1/iso:1 PMID:9363775
GO:0005515 protein bindingPR:O35704-1 mSPTLC1/iso:1 PMID:18484747

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005739 mitochondrionPR:P97363-1 mSPTLC2/iso:1 PMID:18614015