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Protein Ontology report - transcription factor PML
PR:000026474 - http://purl.obolibrary.org/obo/PR_000026474
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000026474   
  PRO nametranscription factor PML 
  Synonyms
PRO-Short-label: EXACT:PML
Gene-based: RELATED:MYL | PP8675 | RNF71 | TRIM19
Other: EXACT:RING finger protein 71 | Tripartite motif-containing protein 19
  Definition"A tripartite motif-containing protein that is a translation product of the human PML gene or a 1:1 ortholog thereof." [PMID:20832753, PRO:CNA, PRO:DAN] 
  PRO Categorygene 
  ParentPR:000044733 tripartite motif-containing protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence5                                                  Organism-Sequence 15                                        
         Modification1                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000026474 transcription factor PML
PML

organism-gene


PR:P29590 protein PML (human)
hPML

organism-sequence


PR:P29590-1 transcription factor PML isoform 1 (human)
hPML/iso:1
Yes
organism-modification


PR:000026480 transcription factor PML isoform 1 phosphorylated 1 (human)
hPML/iso:1/Phos:1
Yes
organism-sequence


PR:P29590-10 protein PML isoform hPML-7 (human)
hPML/iso:hPML-7

organism-sequence


PR:P29590-11 protein PML isoform hPML-11 (human)
hPML/iso:hPML-11

organism-sequence


PR:P29590-12 protein PML isoform hPML-12 (human)
hPML/iso:hPML-12

organism-sequence


PR:P29590-13 protein PML isoform hPML-13 (human)
hPML/iso:hPML-13

organism-sequence


PR:P29590-14 protein PML isoform hPML-14 (human)
hPML/iso:hPML-14

organism-sequence


PR:P29590-2 transcription factor PML isoform 2 (human)
hPML/iso:2
Yes
organism-sequence


PR:P29590-3 transcription factor PML isoform 3 (human)
hPML/iso:3
Yes
organism-sequence


PR:P29590-4 transcription factor PML isoform 4 (human)
hPML/iso:4
Yes
organism-sequence


PR:P29590-5 transcription factor PML isoform 5 (human)
hPML/iso:5
Yes
organism-sequence


PR:P29590-8 protein PML isoform hPML-2 (human)
hPML/iso:hPML-2

organism-sequence


PR:P29590-9 protein PML isoform hPML-3 (human)
hPML/iso:hPML-3

organism-modification


PR:000064635 protein PML sumoylated 1 (human)
hPML/Sumo:1

organism-modification


PR:000076676 protein PML methylated 1 (human)
hPML/Me:1

organism-modification


PR:000079131 protein PML methylated 2 (human)
hPML/Me:2

organism-modification


PR:000080018 protein PML cysteinylated 1 (human)
hPML/Cyst:1

organism-modification


PR:000082789 protein PML cysteinylated 2 (human)
hPML/Cyst:2

organism-gene


PR:Q60953 protein PML (mouse)
mPML

organism-sequence


PR:000045516 protein PML isoform m3 (mouse)
mPml/iso:m3

organism-sequence


PR:Q60953-1 protein PML isoform m1 (mouse)
mPML/iso:m1

organism-sequence


PR:Q60953-2 protein PML isoform m2 (mouse)
mPML/iso:m2

sequence


PR:000026475 transcription factor PML isoform 1
PML/iso:1

organism-sequence


PR:P29590-1 transcription factor PML isoform 1 (human)
hPML/iso:1
Yes
organism-modification


PR:000026480 transcription factor PML isoform 1 phosphorylated 1 (human)
hPML/iso:1/Phos:1
Yes
modification


PR:000026476 transcription factor PML isoform 1 phosphorylated 1
PML/iso:1/Phos:1

organism-modification


PR:000026480 transcription factor PML isoform 1 phosphorylated 1 (human)
hPML/iso:1/Phos:1
Yes
sequence


PR:000026512 transcription factor PML isoform 2
PML/iso:2

organism-sequence


PR:P29590-2 transcription factor PML isoform 2 (human)
hPML/iso:2
Yes
sequence


PR:000026514 transcription factor PML isoform 3
PML/iso:3

organism-sequence


PR:P29590-3 transcription factor PML isoform 3 (human)
hPML/iso:3
Yes
sequence


PR:000026516 transcription factor PML isoform 4
PML/iso:4

organism-sequence


PR:P29590-4 transcription factor PML isoform 4 (human)
hPML/iso:4
Yes
sequence


PR:000026518 transcription factor PML isoform 5
PML/iso:5

organism-sequence


PR:P29590-5 transcription factor PML isoform 5 (human)
hPML/iso:5
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026480 hPML/iso:1/Phos:1
UniProtKB:P29590-1, Ser-403, MOD:00046|Thr-409, MOD:00047		 located_inGO:0005634 nucleus PMID:20832753
PR:P29590-1 hPML/iso:1 enablesGO:0005515 protein binding with PR:Q13164 Big MAP kinase 1 (human) PMID:20832753
located_inGO:0005634 nucleus PMID:16778193
GO:0005737 cytoplasm PMID:9885291
GO:0005737 cytoplasm PMID:9885291
PR:P29590-2 hPML/iso:2 acts_upstream_of_or_withinGO:0002230 positive regulation of defense response to virus by host PMID:16873256
located_inGO:0005634 nucleus PMID:16778193
GO:0005737 cytoplasm PMID:16778193
PR:P29590-3 hPML/iso:3 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:9583681
GO:0030308 negative regulation of cell growth PMID:9583681
GO:0030308 negative regulation of cell growth PMID:9583681
GO:0030308 negative regulation of cell growth PMID:9583681
GO:0030578 PML body organization PMID:10779416
GO:0045930 negative regulation of mitotic cell cycle PMID:9395203
GO:0051726 regulation of cell cycle PMID:9583681
enablesGO:0005515 protein binding with PR:P04489 E4orf3 PMID:10610177
GO:0005515 protein binding with PR:P06400 hRB1 PMID:10610177
GO:0005515 protein binding with PR:P45481 Cbp PMID:10610177
GO:0005515 protein binding with PR:Q64127 E3 ubiquitin-protein ligase Trim24 (mouse) PMID:10610177
GO:0046982 protein heterodimerization activity PMID:7935403
located_inGO:0005634 nucleus PMID:9294197
GO:0005737 cytoplasm PMID:16778193
GO:0031965 nuclear membrane PMID:16778193
PR:P29590-4 hPML/iso:4 acts_upstream_of_or_withinGO:0002230 positive regulation of defense response to virus by host PMID:16873257
GO:0030578 PML body organization PMID:8643677
enablesGO:0005515 protein binding with PR:P14373 hTRIM27 PMID:10669754
GO:0005515 protein binding with PR:P23769 GATA-binding protein 2 (human) PMID:10669754
GO:0005515 protein binding with PR:P63073 eIF-4E (mouse) PMID:10669754
GO:0005515 protein binding with PR:P63165 GAP-modifying protein 1 (human) PMID:10669754
GO:0005515 protein binding with PR:P63279 hUBE2I PMID:10669754
GO:0005515 protein binding with PR:Q03014 HEX PMID:10669754
GO:0005515 protein binding with PR:Q9UER7-1 PMID:10669754
GO:0008270 zinc ion binding PMID:7729428
GO:0050897 cobalt ion binding PMID:7729428
located_inGO:0016605 PML body PMID:9885291
PR:P29590-5 hPML/iso:5 acts_upstream_of_or_withinGO:0006605 protein targeting PMID:15195100
GO:0006605 protein targeting PMID:15195100
GO:0006915 apoptotic process PMID:11080164
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage PMID:12402044
GO:0030308 negative regulation of cell growth PMID:9448006
GO:0032938 negative regulation of translation in response to oxidative stress PMID:16915281
GO:0045892 negative regulation of DNA-templated transcription PMID:9448006
GO:0050821 protein stabilization PMID:12773567
GO:0051726 regulation of cell cycle PMID:12773567
enablesGO:0003713 transcription coactivator activity PMID:15626733
GO:0003713 transcription coactivator activity PMID:15626733
GO:0005515 protein binding with PR:P04637 antigen NY-CO-13 (human) PMID:11259576
GO:0005515 protein binding with PR:P06400 hRB1 PMID:11259576
GO:0005515 protein binding with PR:P62913 60S ribosomal protein L11 (human) PMID:11259576
GO:0005515 protein binding with PR:Q00987 double minute 2 protein (human) PMID:11259576
GO:0005515 protein binding with PR:Q00987 double minute 2 protein (human) PMID:11259576
GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:11259576
GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:11259576
GO:0005515 protein binding with PR:Q13547 HD1 (human) PMID:11259576
GO:0005515 protein binding with PR:Q92547 DNA topoisomerase II-beta-binding protein 1 (human) PMID:11259576
GO:0005515 protein binding with PR:Q92769 HD2 (human) PMID:11259576
GO:0005515 protein binding PMID:11259576
GO:0005515 protein binding PMID:11259576
located_inGO:0005730 nucleolus PMID:16778193
GO:0005737 cytoplasm PMID:16778193
GO:0016363 nuclear matrix PMID:11080164
GO:0016605 PML body PMID:9448006