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Protein Ontology report - estrogen receptor isoform 1
PR:000027721 - http://purl.obolibrary.org/obo/PR_000027721
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000027721   
  PRO nameestrogen receptor isoform 1 
  Synonyms
PRO-Short-label: EXACT:ESR1/iso:1
  Definition"An estrogen receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-1 or a 1:1 ortholog thereof." [PMID:19940156, PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000007204 estrogen receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 1                                        
         Modification6                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
sequence



PR:000027721

estrogen receptor isoform 1

ESR1/iso:1


"An estrogen receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-1 or a 1:1 ortholog thereof." [PMID:19940156, PRO:CNA]


organism-sequence



PR:P03372-1

estrogen receptor isoform 1 (human)

hESR1/iso:1


"An estrogen receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000027724

estrogen receptor isoform 1 phosphorylated 1 (human)

hESR1/iso:1/Phos:1


"An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]

Yes

organism-modification



PR:000027726

estrogen receptor isoform 1 phosphorylated 2 (human)

hESR1/iso:1/Phos:2


"An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]

Yes

organism-modification



PR:000027754

estrogen receptor isoform 1 phosphorylated 3 (human)

hESR1/iso:1/Phos:3


"An estrogen receptor isoform 1 phosphorylated 3 in human. UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD]


organism-modification



PR:000027756

estrogen receptor isoform 1 acetylated 1 (human)

hESR1/iso:1/Ac:1


"An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]

Yes

organism-modification



PR:000027776

estrogen receptor isoform 1 phosphorylated 4 (human)

hESR1/iso:1/Phos:4


"An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]

Yes

organism-modification



PR:000027778

estrogen receptor isoform 1 phosphorylated 5 (human)

hESR1/iso:1/Phos:5


"An estrogen receptor isoform 1 phosphorylated 5 in human. UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]


modification



PR:000027723

estrogen receptor isoform 1 phosphorylated 1

ESR1/iso:1/Phos:1


"An estrogen receptor isoform 1 that has been phosphorylated at the Ser residue within the most C-terminal CK-2 phosphorylation consensus sequence S-x(2)-[DE] in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This is one of the major phosphorylation sites needed for activation of the receptor. Example: UniProtKB:P03372-1, Ser-167, MOD:00046." [Pfam:PF02159, PMID:19940156, PRO:PD]


organism-modification



PR:000027724

estrogen receptor isoform 1 phosphorylated 1 (human)

hESR1/iso:1/Phos:1


"An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]

Yes

modification



PR:000027725

estrogen receptor isoform 1 phosphorylated 2

ESR1/iso:1/Phos:2


"An estrogen receptor isoform 1 that has been phosphorylated at the Tyr residue within the two YxxP motifs, on located in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159), the other in the zf-C4 (Pfam:PF00105) domain. Example: UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]


organism-modification



PR:000027726

estrogen receptor isoform 1 phosphorylated 2 (human)

hESR1/iso:1/Phos:2


"An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]

Yes

modification



PR:000027753

estrogen receptor isoform 1 phosphorylated 3

ESR1/iso:1/Phos:3


"An estrogen receptor isoform 1 that has been phosphorylated on a Ser residue in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This phosphorylation site is involved in modulating the expression of genes downregulated by 17-beta-estradiol and 4-Hydroxytamoxifen. Example: UniProtKB:P03372-1, Ser-118, MOD:00046." [Pfam:PF02159, PMID:17615152, PRO:PD]


organism-modification



PR:000027754

estrogen receptor isoform 1 phosphorylated 3 (human)

hESR1/iso:1/Phos:3


"An estrogen receptor isoform 1 phosphorylated 3 in human. UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD]


modification



PR:000027755

estrogen receptor isoform 1 acetylated 1

ESR1/iso:1/Ac:1


"An estrogen receptor isoform 1 that has been acetylated at two conserved lysine residues in the DNA- binding domain. Acetylation of these lysines increases the DNA- binding activity of estrogen receptor isoform 1. Example: UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]


organism-modification



PR:000027756

estrogen receptor isoform 1 acetylated 1 (human)

hESR1/iso:1/Ac:1


"An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]

Yes

modification



PR:000027775

estrogen receptor isoform 1 phosphorylated 4

ESR1/iso:1/Phos:4


"An estrogen receptor isoform 1 that has been phosphorylated on a Thr located in the helix 1 of the hormone binding domain. This highly conserved Thr residue is part of a leucine -rich nuclear export signal sequence and phosphorylation at this site blocks ERalpha nuclear export and promotes its transcriptional activation. Example: UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]


organism-modification



PR:000027776

estrogen receptor isoform 1 phosphorylated 4 (human)

hESR1/iso:1/Phos:4


"An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]

Yes

modification



PR:000027777

estrogen receptor isoform 1 phosphorylated 5

ESR1/iso:1/Phos:5


"An estrogen receptor isoform 1 that has been phosphorylated at two Ser residues within the N-terminal activation function 1 (AF1) domain (Pfam:PF02159) in response to reactive oxygen species. Example: UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]


organism-modification



PR:000027778

estrogen receptor isoform 1 phosphorylated 5 (human)

hESR1/iso:1/Phos:5


"An estrogen receptor isoform 1 phosphorylated 5 in human. UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027724 hESR1/iso:1/Phos:1
UniProtKB:P03372-1, Ser-167, MOD:00046
acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:19940156
PR:000027726 hESR1/iso:1/Phos:2
UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048
acts_upstream_of_or_withinGO:0010628 positive regulation of gene expression PMID:20101225
enablesGO:0042803 protein homodimerization activity PMID:20101225
located_inGO:0005634 nucleus PMID:20101225
PR:000027756 hESR1/iso:1/Ac:1
UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064
enablesGO:0003677 DNA binding PMID:16497729
PR:000027776 hESR1/iso:1/Phos:4
UniProtKB:P03372-1, Thr-311, MOD:00047
acts_upstream_of_or_withinGO:0010628 positive regulation of gene expression PMID:12138194
located_inGO:0005634 nucleus PMID:12138194