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sequence
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PR:000027721 |
estrogen receptor isoform 1
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ESR1/iso:1
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"An estrogen receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-1 or a 1:1 ortholog thereof." [PMID:19940156, PRO:CNA]
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organism-sequence
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PR:P03372-1 |
estrogen receptor isoform 1 (human)
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hESR1/iso:1
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"An estrogen receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
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PR:000027724 |
estrogen receptor isoform 1 phosphorylated 1 (human)
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hESR1/iso:1/Phos:1
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"An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]
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Yes |
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organism-modification
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PR:000027726 |
estrogen receptor isoform 1 phosphorylated 2 (human)
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hESR1/iso:1/Phos:2
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"An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]
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Yes |
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organism-modification
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PR:000027754 |
estrogen receptor isoform 1 phosphorylated 3 (human)
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hESR1/iso:1/Phos:3
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"An estrogen receptor isoform 1 phosphorylated 3 in human. UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD]
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organism-modification
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PR:000027756 |
estrogen receptor isoform 1 acetylated 1 (human)
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hESR1/iso:1/Ac:1
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"An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]
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Yes |
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organism-modification
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PR:000027776 |
estrogen receptor isoform 1 phosphorylated 4 (human)
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hESR1/iso:1/Phos:4
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"An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]
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Yes |
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organism-modification
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PR:000027778 |
estrogen receptor isoform 1 phosphorylated 5 (human)
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hESR1/iso:1/Phos:5
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"An estrogen receptor isoform 1 phosphorylated 5 in human. UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]
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modification
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PR:000027723 |
estrogen receptor isoform 1 phosphorylated 1
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ESR1/iso:1/Phos:1
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"An estrogen receptor isoform 1 that has been phosphorylated at the Ser residue within the most C-terminal CK-2 phosphorylation consensus sequence S-x(2)-[DE] in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This is one of the major phosphorylation sites needed for activation of the receptor. Example: UniProtKB:P03372-1, Ser-167, MOD:00046." [Pfam:PF02159, PMID:19940156, PRO:PD]
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organism-modification
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PR:000027724 |
estrogen receptor isoform 1 phosphorylated 1 (human)
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hESR1/iso:1/Phos:1
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"An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]
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Yes |
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modification
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PR:000027725 |
estrogen receptor isoform 1 phosphorylated 2
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ESR1/iso:1/Phos:2
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"An estrogen receptor isoform 1 that has been phosphorylated at the Tyr residue within the two YxxP motifs, on located in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159), the other in the zf-C4 (Pfam:PF00105) domain. Example: UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]
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organism-modification
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PR:000027726 |
estrogen receptor isoform 1 phosphorylated 2 (human)
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hESR1/iso:1/Phos:2
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"An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]
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Yes |
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modification
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PR:000027753 |
estrogen receptor isoform 1 phosphorylated 3
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ESR1/iso:1/Phos:3
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"An estrogen receptor isoform 1 that has been phosphorylated on a Ser residue in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This phosphorylation site is involved in modulating the expression of genes downregulated by 17-beta-estradiol and 4-Hydroxytamoxifen. Example: UniProtKB:P03372-1, Ser-118, MOD:00046." [Pfam:PF02159, PMID:17615152, PRO:PD]
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organism-modification
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PR:000027754 |
estrogen receptor isoform 1 phosphorylated 3 (human)
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hESR1/iso:1/Phos:3
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"An estrogen receptor isoform 1 phosphorylated 3 in human. UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD]
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modification
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PR:000027755 |
estrogen receptor isoform 1 acetylated 1
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ESR1/iso:1/Ac:1
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"An estrogen receptor isoform 1 that has been acetylated at two conserved lysine residues in the DNA- binding domain. Acetylation of these lysines increases the DNA- binding activity of estrogen receptor isoform 1. Example: UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]
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organism-modification
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PR:000027756 |
estrogen receptor isoform 1 acetylated 1 (human)
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hESR1/iso:1/Ac:1
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"An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]
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Yes |
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modification
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PR:000027775 |
estrogen receptor isoform 1 phosphorylated 4
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ESR1/iso:1/Phos:4
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"An estrogen receptor isoform 1 that has been phosphorylated on a Thr located in the helix 1 of the hormone binding domain. This highly conserved Thr residue is part of a leucine -rich nuclear export signal sequence and phosphorylation at this site blocks ERalpha nuclear export and promotes its transcriptional activation. Example: UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]
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organism-modification
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PR:000027776 |
estrogen receptor isoform 1 phosphorylated 4 (human)
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hESR1/iso:1/Phos:4
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"An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]
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Yes |
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modification
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PR:000027777 |
estrogen receptor isoform 1 phosphorylated 5
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ESR1/iso:1/Phos:5
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"An estrogen receptor isoform 1 that has been phosphorylated at two Ser residues within the N-terminal activation function 1 (AF1) domain (Pfam:PF02159) in response to reactive oxygen species. Example: UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]
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organism-modification
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PR:000027778 |
estrogen receptor isoform 1 phosphorylated 5 (human)
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hESR1/iso:1/Phos:5
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"An estrogen receptor isoform 1 phosphorylated 5 in human. UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]
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