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Protein Ontology report - aurora kinase
PR:000035365 - http://purl.obolibrary.org/obo/PR_000035365
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000035365   
  PRO nameaurora kinase 
  Synonyms
Other: EXACT:AURK
  Definition"A protein that is a serine-threonine protein kinase that controls several aspects of cell division. It contains a copy of the Protein kinase domain (Pfam:PF00069)." [PIRSF:PIRSF501130, PMID:18662747, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 18                                        
         Sequence0                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF501130
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000035365 aurora kinase
hCENPA/InitMet-/Phos:1

gene


PR:000004515 aurora kinase A
AURKA

organism-gene


PR:O14965 aurora kinase A (human)
hAURKA
Yes
organism-modification


PR:000045573 aurora kinase A phosphorylated 1 (human)
hAURKA/Phos:1

organism-modification


PR:000046439 aurora kinase A sumoylated 1 (human)
hAURKA/Sumo:1

organism-modification


PR:000064814 aurora kinase A ubiquitinated form (human)
hAURKA/UbiqLys+

organism-modification


PR:000084713 aurora kinase A hydroxylated 1 (human)
hAURKA/Hy:1

organism-gene


PR:P59241 aurora kinase A (rat)
rAURKA

organism-gene


PR:P97477 aurora kinase A (mouse)
mAURKA

organism-sequence


PR:P97477-1 aurora kinase A isoform m1 (mouse)
mAURKA/iso:m1

organism-sequence


PR:P97477-2 aurora kinase A isoform m2 (mouse)
mAURKA/iso:m2

gene


PR:000004517 aurora kinase B
AURKB

organism-gene


PR:000060242 serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe)
Spom-AURKB

organism-gene


PR:O01427 aurora/IPL1-related protein kinase 2 (worm)
AURKB (worm)

organism-gene


PR:O55099 aurora kinase B (rat)
rAURKB

organism-gene


PR:O59790 serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe 972h-)
Spom972h-AURKB

organism-gene


PR:O70126 aurora kinase B (mouse)
mAURKB

organism-gene


PR:Q6DE08 aurora kinase B-A (frog)
frog-AURKB

organism-gene


PR:Q6NW76 aurora kinase B (zebrafish)
z-AURKB

organism-gene


PR:Q96GD4 aurora kinase B (human)
hAURKB
Yes
organism-sequence


PR:Q96GD4-1 aurora kinase B isoform h1 (human)
hAURKB/iso:h1

organism-sequence


PR:Q96GD4-2 aurora kinase B isoform h2 (human)
hAURKB/iso:h2

organism-sequence


PR:Q96GD4-3 aurora kinase B isoform h3 (human)
hAURKB/iso:h3

organism-sequence


PR:Q96GD4-4 aurora kinase B isoform h4 (human)
hAURKB/iso:h4

organism-sequence


PR:Q96GD4-5 aurora kinase B isoform h5 (human)
hAURKB/iso:h5

organism-modification


PR:000035661 aurora kinase B unphosphorylated form (human)
hAURKB/PhosRes-
Yes
organism-modification


PR:000035663 aurora kinase B phosphorylated 1 (human)
hAURKB/Phos:1
Yes
organism-modification


PR:000046026 aurora kinase B phosphorylated 2 (human)
hAURKB/Phos:2

organism-modification


PR:000046440 aurora kinase B sumoylated 1 (human)
hAURKB/Sumo:1

organism-modification


PR:000075980 aurora kinase B methylated 1 (human)
hAURKB/Me:1

organism-modification


PR:000077527 aurora kinase B cysteinylated 1 (human)
hAURKB/Cyst:1

organism-gene


PR:Q9VKN7 aurora kinase B (fruit fly)
fly-AURKB

modification


PR:000019090 aurora kinase B, initiator methionine removed form
AURKB/InitMet-

modification


PR:000035660 aurora kinase B unphosphorylated form
AURKB/PhosRes-

organism-modification


PR:000035661 aurora kinase B unphosphorylated form (human)
hAURKB/PhosRes-
Yes
modification


PR:000035662 aurora kinase B phosphorylated 1
AURKB/Phos:1

organism-modification


PR:000035663 aurora kinase B phosphorylated 1 (human)
hAURKB/Phos:1
Yes
gene


PR:000004518 aurora kinase C
AURKC

organism-gene


PR:D4AD76 aurora kinase C (rat)
rAURKC

organism-gene


PR:O64629 serine/threonine-protein kinase Aurora-3 (Arabidopsis thaliana)
At-AURKC

organism-gene


PR:O88445 aurora kinase C (mouse)
mAURKC

organism-gene


PR:Q9UQB9 aurora kinase C (human)
hAURKC

organism-sequence


PR:Q9UQB9-1 aurora kinase C isoform h1 (human)
hAURKC/iso:h1

organism-sequence


PR:Q9UQB9-2 aurora kinase C isoform h2 (human)
hAURKC/iso:h2

organism-sequence


PR:Q9UQB9-3 aurora kinase C isoform h3 (human)
hAURKC/iso:h3

gene


PR:000029237 spindle assembly checkpoint kinase
IPL1

organism-gene


PR:P38991 spindle assembly checkpoint kinase (yeast)
yIPL1
Yes
organism-gene


PR:Q54WX4 aurora kinase (Dictyostelium discoideum)
Dicty-IPL1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035661 hAURKB/PhosRes- enablesGO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:22024163
located_inGO:0000776 kinetochore PMID:22024163
PR:000035663 hAURKB/Phos:1
UniProtKB:Q96GD4, Ser-331, MOD:00046		 acts_upstream_of_or_withinincreased GO:0007059 chromosome segregation relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
increased GO:0031577 spindle checkpoint signaling relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
increased GO:0051310 metaphase chromosome alignment relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
enablesincreased GO:0004672 protein kinase activity relative to PR:000035661 hAURKB/PhosRes- PMID:17276342; PMID:22024163
GO:0005515 protein binding PMID:22024163
located_inGO:0000776 kinetochore PMID:22024163
PR:O14965 hAURKA enablesGO:0005515 protein binding with PR:Q9H4B4 CNK PMID:15190214
located_inGO:0000922 spindle pole PMID:15190214
GO:0005813 centrosome PMID:15190214
GO:0030496 midbody PMID:15190214
PR:P38991 yIPL1 enablesGO:0004672 protein kinase activity PMID:17504936
PR:Q96GD4 hAURKB acts_upstream_of_or_withinGO:0007059 chromosome segregation PMID:12719470
GO:0008608 attachment of spindle microtubules to kinetochore PMID:12719470; PMID:15592459
GO:0031577 spindle checkpoint signaling PMID:12719470
GO:0034501 protein localization to kinetochore PMID:12719470; PMID:17617734; PMID:22732840
NOT GO:0051306 mitotic sister chromatid separation PMID:12719470
GO:0051310 metaphase chromosome alignment PMID:12719470; PMID:22732840
GO:0071459 protein localization to chromosome, centromeric region PMID:12719470; PMID:21658950
GO:0140014 mitotic nuclear division PMID:12719470
enablesGO:0004672 protein kinase activity PMID:12719470
GO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:P06493 CDC2 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:P68431 H3C1 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q13043 hSTK4 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q15208 hSTK38 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q53HL2 CDCA8 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q71DI3 H3-clustered histone 13 (human) BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
located_inGO:0000776 kinetochore PMID:20624902
GO:0000779 condensed chromosome, centromeric region PMID:12719470; PMID:15917996
GO:0000939 inner kinetochore PMID:15592459
GO:0030496 midbody PMID:15917996
GO:0051233 spindle midzone PMID:15917996