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Protein Ontology report - BUB1 CDK-consensus sites phosphorylated form
PR:000035413 -
http://purl.obolibrary.org/obo/PR_000035413
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000035413
PRO name
BUB1 CDK-consensus sites phosphorylated form
Synonyms
PRO-Short-label
:
EXACT:
BUB1/PhosRes+
Definition
"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is phosphorylated on CDK consensus sites (S/T-P-X-K/R) located in the middle region of BUB1." [
PMID:12606573
,
PMID:16760428
, PRO:KER]
PRO Category
modification
Parent
PR:000004854
mitotic checkpoint serine/threonine-protein kinase BUB1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
modification
PR:000035413
BUB1 CDK-consensus sites phosphorylated form
BUB1/PhosRes+
"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is phosphorylated on CDK consensus sites (S/T-P-X-K/R) located in the middle region of BUB1." [PMID:12606573, PMID:16760428, PRO:KER]
organism-modification
PR:000035411
mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-)
Spom972h-BUB1/Phos:6
"A BUB1 CDK-consensus sites phosphorylated form in Schizosaccharomyces pombe 972h-. The exact combination of phosphorylated sites is not known but may involve Thr-340, Thr-423, Thr-455, and/or Ser-466 of the amino acid sequence represented by UniProtKB:O94751. UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)." [PMID:12606573, PRO:DAN, PRO:KER]
Yes
organism-modification
PR:000035412
mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)
hBUB1/Phos:7
"A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER]
Yes
Yes
organism-modification
PR:000035419
mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 1 (yeast)
yBUB1/Phos:CDK-1
"A BUB1 CDK-consensus sites phosphorylated form in yeast that has phosphorylation at Thr-566. This phosphorylation is essential for deactivating the spindle checkpoint in anaphase and adaptation to prolonged mitotic arrest. UniProtKB:P41695, Thr-566, MOD:00047." [PMID:21298086, PRO:KER]
Yes
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BUB1/PhosRes+
forms found in complexes
BUB1/PhosRes+
Component
Complexes
PR:000035412
hBUB1/Phos:7
PR:000035581
phosphoBUB1:PLK1 complex (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000035411
Spom972h-BUB1/Phos:6
UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)
acts_upstream_of_or_within
GO:0007094
mitotic spindle assembly checkpoint signaling
PMID:12606573
GO:0045143
homologous chromosome segregation
PMID:12606573
located_in
GO:0000776
kinetochore
PMID:12606573
PR:000035412
hBUB1/Phos:7
Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047
acts_upstream_of_or_within
GO:0034501
protein localization to kinetochore
PMID:16760428
enables
increased
GO:0005515
protein binding
with
PR:Q9NQS7
hINCENP
PMID:16760428
PR:000035419
yBUB1/Phos:CDK-1
UniProtKB:P41695, Thr-566, MOD:00047
acts_upstream_of_or_within
NOT
GO:0031577
spindle checkpoint signaling
PMID:21298086
