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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
PR:000035428 -
http://purl.obolibrary.org/obo/PR_000035428
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:000035428
PRO name
mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hBUB1B/Phos:2
PRO-proteoform-std
:
NARROW:
UniProtKB:O60566-1
, Thr-620,
MOD:00047
|(Ser-676,
MOD:00046
and/or Thr-680,
MOD:00047
)|(Thr-792,
MOD:00047
and/or Thr-1008,
MOD:00047
)
Other
:
RELATED:
BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
Definition
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example:
UniProtKB:O60566-1
, Thr-620,
MOD:00047
|(Ser-676,
MOD:00046
and/or Thr-680,
MOD:00047
)|(Thr-792,
MOD:00047
and/or Thr-1008,
MOD:00047
)." [
PMID:10593653
,
PMID:11030144
,
PMID:11792804
,
PMID:17276342
,
PMID:17376779
,
PMID:17785528
,
PMID:18440313
,
PMID:23079597
, PRO:KER]
Comment
Note: This phosphorylated form is observed during pro metaphase, spindle depolymerization (nocodazole), and lack of kinetochore tension (taxol). Kinase=("CDK1";
PR:000003271
; Thr-620). Kinase=("PLK1";
PR:P53350
; Ser-676/Thr-680).
PRO Category
organism-modification
Parent
PR:000035427
mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
PR:O60566
mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)
Taxon
NCBITaxon:9606
Homo sapiens
Term Hierarchy
Visualization
DAG:
OLS:
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hBUB1B/Phos:2
forms found in complexes
hBUB1B/Phos:2
Component
Complexes
PR:000035428
hBUB1B/Phos:2
PR:000035577
BUB1:phosphoBUB1B complex (human)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000035428
hBUB1B/Phos:2
Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)
acts_upstream_of_or_within
GO:0006974
DNA damage response
PMID:18440313
increased
GO:0008608
attachment of spindle microtubules to kinetochore
relative to
PR:000035425
frog-BUB1B/PhosRes-
PMID:17785528
increased
GO:0051310
metaphase chromosome alignment
relative to
PR:000035425
frog-BUB1B/PhosRes-
PMID:17376779
;
PMID:17785528
enables
increased
GO:0004672
protein kinase activity
relative to
PR:000035425
frog-BUB1B/PhosRes-
PMID:17376779
increased
GO:0005515
protein binding
with
PR:O43683
BUB1
PMID:23079597
increased
GO:0005515
protein binding
with
PR:Q15172
hPPP2R5A
PMID:23079597
increased
GO:0005515
protein binding
relative to
PR:000035425
frog-BUB1B/PhosRes-
PMID:23079597
located_in
GO:0000776
kinetochore
PMID:17785528