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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
PR:000035428 - http://purl.obolibrary.org/obo/PR_000035428
 
    Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:000035428   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hBUB1B/Phos:2
PRO-proteoform-std: NARROW:UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)
Other: RELATED:BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
  Definition"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER] 
  CommentNote: This phosphorylated form is observed during pro metaphase, spindle depolymerization (nocodazole), and lack of kinetochore tension (taxol). Kinase=("CDK1"; PR:000003271; Thr-620). Kinase=("PLK1"; PR:P53350; Ser-676/Thr-680). 
  PRO Categoryorganism-modification 
  ParentPR:000035427 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Term Hierarchy
  Visualization
DAG: OLS:
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hBUB1B/Phos:2 forms found in complexes   

hBUB1B/Phos:2 Component
 Complexes
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006974 DNA damage responsePR:000035428 hBUB1B/Phos:2 PMID:18440313
increased GO:0008608 attachment of spindle microtubules to kinetochorePR:000035428 hBUB1B/Phos:2 PMID:17785528
increased GO:0051310 metaphase chromosome alignmentPR:000035428 hBUB1B/Phos:2 PMID:17376779; PMID:17785528

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004672 protein kinase activityPR:000035428 hBUB1B/Phos:2 PMID:17376779
GO:0005515 protein bindingPR:000035428 hBUB1B/Phos:2 PMID:23079597
PR:000035428 hBUB1B/Phos:2 PMID:23079597
PR:000035428 hBUB1B/Phos:2 PMID:23079597

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0000776 kinetochorePR:000035428 hBUB1B/Phos:2 PMID:17785528