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Protein Ontology report - NS1
PR:000036824 - http://purl.obolibrary.org/obo/PR_000036824
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036824   
  PRO nameNS1 
  Synonyms
PRO-Short-label: EXACT:DenV-NS1
Other: EXACT:non-structural protein 1
  Definition"A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:ES] 
  CommentRequested by=IDODEN. NS1 is a secreted glycoprotein that is absent from viral particles but accumulates in the supernatant and on the plasma membrane of cells during infection. Because it derives from a glycosylated precursor it includes two N-glycosylated residues at Asn-130 and Asn-207. [PMID:18052531, PRO:ES]. 
  PRO Categorymodification 
  ParentPR:000036818 dengue virus genome polyprotein proteolytic cleavage product
PR:000036998 NS1-NS2A
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification3                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
modification


PR:000036824
NS1
DenV-NS1
"A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:ES]

Yes
modification


PR:000037000
NS1, with complex sugar attached
DenV-NS1/sugar(+)
"An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]

Yes
modification


PR:000037001
NS1, without complex sugar attached
DenV-NS1/sugar(-)
"An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]

Yes
organism-modification


PR:000044758
NS1 (Dengue virus 2 Thailand/NGS-C/1944)
NS1 (DEN2N)
"An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx]
Yes
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DenV-NS1 forms found in complexes   

DenV-NS1 Component
 Complexes
PR:000036824 DenV-NS1 PR:000037002 NS1 dimer
PR:000037000 DenV-NS1/sugar(+) PR:000037003 NS1 dimer, with complex sugar attached
PR:000037005 NS1 hexamer, with complex sugar attached
PR:000037001 DenV-NS1/sugar(-) PR:000037004 NS1 dimer, without complex sugar unattached
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0019079 viral genome replicationPR:000044758 NS1 (DEN2N) PMID:23408612
GO:0097281 immune complex formationPR:000044758 NS1 (DEN2N) PMID:23408612

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0019034 viral replication complexPR:000044758 NS1 (DEN2N) PMID:23408612