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Protein Ontology report - chymotrypsin-like elastase family member 2A, mature form (mouse)
PR:000037245 - http://purl.obolibrary.org/obo/PR_000037245
 
    Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:000037245   
  PRO namechymotrypsin-like elastase family member 2A, mature form (mouse) 
  Synonyms
PRO-Short-label: EXACT:mCELA2A/mature
PRO-proteoform-std: EXACT:UniProtKB:P05208, 31-271
PRO-proteoform-ftid: EXACT:PRO_0000027688
Other: RELATED:Cela2a (mouse) | Ela2 (mouse) | elastase 2 (mouse)
  Definition"A chymotrypsin-like elastase family member 2A, pro-form (mouse) that has had the activation peptide removed by proteolytic cleavage. UniProtKB:P05208, 31-271." [PMID:20179351, PMID:3641189, PRO:KRC] 
  CommentNote: Figure 3C in PMID:20179351 shows the Western blot analysis of WT and Tg-ELA2 (Tg) epidermal and dermal extracts, using an anti-FLAG antibody, revealing exogenous ELA2flag as pro-forms and active forms in the epidermis of transgenic animals. Figure 1 in PMID:3641189 shows sequence of mRNA corresponding to preproenzyme and presumes start site of active enzyme based on homology with porcine enzyme. 
  PRO Categoryorganism-modification 
  ParentPR:000028941 activated trypsin
PR:000037244 chymotrypsin-like elastase family member 2A, pro-form (mouse)
  TaxonNCBITaxon:10090 Mus musculus
  Term Hierarchy
  Visualization
DAG: OLS:
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006508 proteolysisPR:000037245 mCELA2A/mature MGI_ref:4440399; PMID:20179351
GO:0061436 establishment of skin barrierPR:000037245 mCELA2A/mature MGI_ref:4440399; PMID:20179351

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0017171 serine hydrolase activityPR:000037245 mCELA2A/mature MGI_ref:4440399; PMID:20179351
PR:000037245 mCELA2A/mature MGI_ref:4440399; PMID:20179351