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PRO ID
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PRO name | viral dsRNA:TLR3 complex |
Synonyms | PRO-Short-label: | EXACT: | (vir)dsRNA:TLR3 | |
Definition | "A macromolecular complex that is composed of viral double stranded RNA (dsRNA) and a homodimer of TLR3. Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positively charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA." [PMID:18420935, PMID:20861016, PRO:CNA, PRO:DAN, Reactome:R-HSA-167985] |
Comment | Requested by=TLR. |
PRO Category | complex |
Parent | G0032991 protein-containing complex
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Terms by PRO Category |
Organism-Independent |
Organism-Specific |
Category |
Number of Terms |
Category |
Number of Terms | Complex | 1 |
Organism-Complex |
3 | | | |
Term Hierarchy Visualizationccc |
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