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Documentation
Protein Ontology report - IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
PR:000037353 -
http://purl.obolibrary.org/obo/PR_000037353
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000037353
PRO name
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
Synonyms
Reactome-displayName
:
RELATED:
activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-TBK1/p-IKKE:IRF3
Definition
"A protein-containing complex that is composed of activated Toll-like receptor 3 (TLR3), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated TBK1 and IRF3 unphosphorylated." [
PMID:14517278
,
PMID:14739303
,
PMID:16281057
]
Comment
Requested by=TLR.
PRO Category
complex
Parent
G0032991
protein-containing complex
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Complex
1
Organism-Complex
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
complex
PR:000037353
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
ARAP3/iso:1
"A protein-containing complex that is composed of activated Toll-like receptor 3 (TLR3), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated TBK1 and IRF3 unphosphorylated." [PMID:14517278, PMID:14739303, PMID:16281057]
organism-complex
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
ARAP3/iso:1
"An IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex whose components are encoded in the genome of human." [PMID:14517278, PMID:14739303, PMID:16281057, PRO:VS]
Yes
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Functional Annotation (GO-centric view)
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PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0002756
MyD88-independent toll-like receptor signaling pathway
PR:000037354
ARAP3/iso:1
Reactome:REACT_6783
GO:0034138
toll-like receptor 3 signaling pathway
PR:000037354
ARAP3/iso:1
Reactome:REACT_6783
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0010008
endosome membrane
PR:000037354
ARAP3/iso:1
Reactome:REACT_6783
