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Protein Ontology report - CD14 molecule cleaved 2 (human)
PR:000037480 - http://purl.obolibrary.org/obo/PR_000037480
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000037480   
  PRO nameCD14 molecule cleaved 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hCD14/Clv:2
PRO-proteoform-std: EXACT:UniProtKB:P08571, 20-345
PRO-proteoform-ftid: EXACT:PRO_0000020885
Other: RELATED:CD14 molecule (human)
  Definition"A CD14 molecule cleaved 2 in human. This represents both the GPI-anchored and soluble forms. UniProtKB:P08571, 20-345." [PRO:CNA, PRO:DAN] 
  PRO Categoryorganism-modification 
  ParentPR:000036848 CD14 molecule cleaved 2
PR:P08571 monocyte differentiation antigen CD14 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-modification


PR:000037480
CD14 molecule cleaved 2 (human)
hCD14/Clv:2
"A CD14 molecule cleaved 2 in human. This represents both the GPI-anchored and soluble forms. UniProtKB:P08571, 20-345." [PRO:CNA, PRO:DAN]

Yes
organism-modification


PR:000035702
CD14 molecule cleaved 2 GPI-anchored form (human)
hCD14/Clv:2/anchored
"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]
Yes
Yes
organism-modification


PR:000035703
CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]
Yes
Yes
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hCD14/Clv:2 forms found in complexes   

hCD14/Clv:2 Component
 Complexes
PR:000035702 hCD14/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000037480 hCD14/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0034142 toll-like receptor 4 signaling pathwayPR:000035702 hCD14/Clv:2/anchored Reactome:REACT_6894
PR:000035703 hCD14/Clv:2/soluble Reactome:REACT_6894

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0001530 lipopolysaccharide bindingPR:000035703 hCD14/Clv:2/soluble PMID:9464818

Cellular Location GO Term
Protein Forms & Complexes
Evidence
CL:0000129 microglial cellPR:000035703 hCD14/Clv:2/soluble PMID:24659539
GO:0005576 extracellular regionPR:000035703 hCD14/Clv:2/soluble PMID:2779588; PMID:9665271
GO:0005886 plasma membranePR:000035702 hCD14/Clv:2/anchored Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored Reactome:REACT_7740
PR:000035702 hCD14/Clv:2/anchored Reactome:REACT_7740