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Protein Ontology report - neuregulin-1 type I-beta1a
PR:000044820 - http://purl.obolibrary.org/obo/PR_000044820
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000044820   
  PRO nameneuregulin-1 type I-beta1a 
  Synonyms
PRO-Short-label: EXACT:NRG1/iso:Ibeta1a
Other: RELATED:NRG beta1 | NRG beta1a
  Definition"A pro-neuregulin-1, membrane-bound isoform that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02297-6 or a 1:1 ortholog thereof." [PMID:12648463, PRO:KRC] 
  PRO Categorysequence 
  ParentPR:000029649 pro-neuregulin-1, membrane-bound isoform
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
sequence



PR:000044820

neuregulin-1 type I-beta1a

NRG1/iso:Ibeta1a


"A pro-neuregulin-1, membrane-bound isoform that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02297-6 or a 1:1 ortholog thereof." [PMID:12648463, PRO:KRC]


organism-sequence



PR:P43322-5

neuregulin-1 type I-beta1a (rat)

rNRG1/iso:Ibeta1a


"A neuregulin-1 type I-beta1a that is encoded in the genome of rat." [PRO:CNA, UniProtKB:P43322]


organism-sequence



PR:Q02297-6

neuregulin-1 type I-beta1a (human)

hNRG1/iso:Ibeta1a


"A neuregulin-1 type I-beta1a that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q02297]


organism-sequence



PR:Q6DR98-1

neuregulin-1 type I-beta1a (mouse)

mNRG1/iso:Ibeta1a


"A neuregulin-1 type I-beta1a that is encoded in the genome of mouse." [PMID:11116142, PRO:KRC]


organism-modification



PR:000044821

neuregulin-1 type I-beta1a mature form (mouse)

mNRG1/iso:Ibeta1a/mature


"A neuregulin-1 type I-beta1a (mouse) that has been proteolytically processed by the Meltrin beta/ADAM19 metalloprotease to produce a soluble form consisting of the ectodomain." [PMID:11116142, PRO:KRC]

Yes

organism-modification



PR:000044823

neuregulin-1 type I-beta1a transmembrane precursor (mouse)

mNRG1/iso:Ibeta1a/precursor


"A neuregulin-1 type I-beta1a (mouse) that has not been proteolytically processed." [PMID:11116142, PRO:KRC]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044821 mNRG1/iso:Ibeta1a/mature acts_upstream_of_or_withinGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:3625788; PMID:11116142
located_inGO:0005576 extracellular region MGI_ref:3625788; PMID:11116142