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Protein Ontology report - transforming growth factor beta-1, signal peptide removed form (human)

PR:000049430 - http://purl.obolibrary.org/obo/PR_000049430

Protein Forms

Annotations

Ontology Information

Show OBO stanza

GPI

PRO ID

PR:000049430

PRO name

transforming growth factor beta-1, signal peptide removed form (human)

Synonyms

PRO-Short-label:	EXACT:	hTGFB1/SigPep-
PRO-proteoform-std:	EXACT:	UniProtKB:P01137, 30-390

Definition

"A transforming growth factor beta-1 (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390." [PRO:DNx, Reactome:R-HSA-114705]

PRO Category

organism-modification

Parent

PR:000018291 TGF-beta 1, signal peptide removed form
PR:P01137 transforming growth factor beta-1 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	0	Organism-Modification	18

Term Hierarchy
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Protein Forms

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Category

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?

organism-modification

PR:000049430

transforming growth factor beta-1, signal peptide removed form (human)

hTGFB1/SigPep-

"A transforming growth factor beta-1 (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390." [PRO:DNx, Reactome:R-HSA-114705]

organism-modification

PR:000021903

TGF-beta 1 sequence variant T81H, signal peptide removed form (human)

hTGFB1/var:T81H/SigPep-

"A TGF-beta 1 sequence variant T81H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Tyr-81, CHEBI:29979." [PRO:DAN]

organism-modification

PR:000000619

TGF-beta 1 sequence variant T81H cleaved 1 (human)

hTGFB1/var:T81H/Clv:1

"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000000620

TGF-beta 1 sequence variant T81H cleaved 2 (human)

hTGFB1/var:T81H/Clv:2

"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000021904

TGF-beta 1 sequence variant R218C, signal peptide removed form (human)

hTGFB1/var:R218C/SigPep-

"A TGF-beta 1 sequence variant R218C (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950." [PRO:DAN]

organism-modification

PR:000000621

TGF-beta 1 sequence variant R218C cleaved 1 (human)

hTGFB1/var:R218C/Clv:1

"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000000622

TGF-beta 1 sequence variant R218C cleaved 2 (human)

hTGFB1/var:R218C/Clv:2

"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000021905

TGF-beta 1 sequence variant H222D, signal peptide removed form (human)

hTGFB1/var:H222D/SigPep-

"A TGF-beta 1 sequence variant H222D (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, His-222, CHEBI:29958." [PRO:DNx]

organism-modification

PR:000000623

TGF-beta 1 sequence variant H222D cleaved 1 (human)

hTGFB1/var:H222D/Clv:1

"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000000624

TGF-beta 1 sequence variant H222D cleaved 2 (human)

hTGFB1/var:H222D/Clv:2

"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000021906

TGF-beta 1 sequence variant C225R, signal peptide removed form (human)

hTGFB1/var:C225R/SigPep-

"A TGF-beta 1 sequence variant C225R (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Cys-225, CHEBI:29952." [PRO:DAN]

organism-modification

PR:000000625

TGF-beta 1 sequence variant C225R cleaved 1 (human)

hTGFB1/var:C225R/Clv:1

"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000000626

TGF-beta 1 sequence variant C225R cleaved 2 (human)

hTGFB1/var:C225R/Clv:2

"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000021907

TGF-beta 1 sequence variant R218H, signal peptide removed form (human)

hTGFB1/var:R218H/SigPep-

"A TGF-beta 1 sequence variant R218H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29979." [PRO:DAN]

organism-modification

PR:000000627

TGF-beta 1 sequence variant R218H cleaved 1 (human)

hTGFB1/var:R218H/Clv:1

"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000000628

TGF-beta 1 sequence variant R218H cleaved 2 (human)

hTGFB1/var:R218H/Clv:2

"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification

PR:000026335

TGF-beta 1 isoform 1 inactive form (human)

hTGFB1/iso:1/inactive

"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]

Yes

organism-modification

PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP

"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000619 hTGFB1/var:T81H/Clv:1 UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979	located_in	SO:0001558 polypeptide_localization_variant	PMID:12493741
PR:000000620 hTGFB1/var:T81H/Clv:2 UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979	located_in	GO:0005615 extracellular space	PMID:12493741
PR:000000621 hTGFB1/var:R218C/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11062463; PMID:12493741; PMID:12843182
	enables	GO:0005160 transforming growth factor beta receptor binding	PMID:11278244
		increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:11062463; PMID:12493741; PMID:12843182
		GO:0042803 protein homodimerization activity	PMID:11062463; PMID:12493741; PMID:12843182
	located_in	GO:0005615 extracellular space	PMID:11062463; PMID:12493741; PMID:12843182
PR:000000622 hTGFB1/var:R218C/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
PR:000000623 hTGFB1/var:H222D/Clv:1 UniProtKB:P01137, 279-390, His-222, CHEBI:29958	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:12493741
	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	PMID:12493741
	enables	increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:12493741
	located_in	GO:0005615 extracellular space	PMID:12493741
PR:000000624 hTGFB1/var:H222D/Clv:2 UniProtKB:P01137, 30-278, His-222, CHEBI:29958	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
	located_in	SO:0001601 conformational_change_variant	PMID:11278244
PR:000000625 hTGFB1/var:C225R/Clv:1 UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952	enables	increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:11062463; PMID:12493741; PMID:12843182
	located_in	GO:0005615 extracellular space	PMID:11062463; PMID:12493741; PMID:12843182
PR:000000626 hTGFB1/var:C225R/Clv:2 UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
PR:000000627 hTGFB1/var:R218H/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11278244
	enables	GO:0005160 transforming growth factor beta receptor binding	PMID:11278244
		increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein	PMID:12493741; PMID:12843182
		GO:0042803 protein homodimerization activity	PMID:11278244
	located_in	GO:0005615 extracellular space	PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979	located_in	SO:0001561 polypeptide_partial_loss_of_function	PMID:11278244
	located_in	SO:0001601 conformational_change_variant	PMID:11278244
PR:000026335 hTGFB1/iso:1/inactive UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:3162913
	enables	NOT GO:0005160 transforming growth factor beta receptor binding	PMID:2677679; PMID:3162913
	enables	GO:0042803 protein homodimerization activity	PMID:3162913
	located_in	GO:0031012 extracellular matrix	PMID:17015622; PMID:8294500
	located_in	GO:0032991 protein-containing complex	PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160	located_in	GO:0032991 protein-containing complex	PMID:17015622; PMID:3162913