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Protein Ontology report - transforming growth factor beta-1, signal peptide removed form (human)
PR:000049430 - http://purl.obolibrary.org/obo/PR_000049430
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000049430   
  PRO nametransforming growth factor beta-1, signal peptide removed form (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB1/SigPep-
PRO-proteoform-std: EXACT:UniProtKB:P01137, 30-390
  Definition"A transforming growth factor beta-1 (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390." [PRO:DNx, Reactome:R-HSA-114705] 
  PRO Categoryorganism-modification 
  ParentPR:000018291 TGF-beta 1, signal peptide removed form
PR:P01137 transforming growth factor beta-1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 18                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-modification


PR:000049430 transforming growth factor beta-1, signal peptide removed form (human)
hTGFB1/SigPep-

organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human)
hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human)
hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human)
hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human)
hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human)
hTGFB1/var:R218H/Clv:2
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
PR:000026335 hTGFB1/iso:1/inactive PMID:3162913
GO:0043066 negative regulation of apoptotic processPR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005160 transforming growth factor beta receptor bindingPR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11278244
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
NOT GO:0005160 transforming growth factor beta receptor bindingPR:000026335 hTGFB1/iso:1/inactive PMID:2677679; PMID:3162913
GO:0008083 growth factor activityPR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741
PR:000000625 hTGFB1/var:C225R/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activityPR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
PR:000026335 hTGFB1/iso:1/inactive PMID:3162913

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000000620 hTGFB1/var:T81H/Clv:2 PMID:12493741
PR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741
PR:000000625 hTGFB1/var:C225R/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
GO:0031012 extracellular matrixPR:000026335 hTGFB1/iso:1/inactive PMID:17015622; PMID:8294500
GO:0032991 protein-containing complexPR:000026335 hTGFB1/iso:1/inactive PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP PMID:17015622; PMID:3162913
SO:0001558 polypeptide_localization_variantPR:000000619 hTGFB1/var:T81H/Clv:1 PMID:12493741
SO:0001561 polypeptide_partial_loss_of_functionPR:000000622 hTGFB1/var:R218C/Clv:2 PMID:11278244
PR:000000624 hTGFB1/var:H222D/Clv:2 PMID:11278244
PR:000000626 hTGFB1/var:C225R/Clv:2 PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2 PMID:11278244
SO:0001601 conformational_change_variantPR:000000624 hTGFB1/var:H222D/Clv:2 PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2 PMID:11278244