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Protein Ontology report - transforming growth factor beta-1, signal peptide removed form (human)
PR:000049430 - http://purl.obolibrary.org/obo/PR_000049430
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000049430   
  PRO nametransforming growth factor beta-1, signal peptide removed form (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB1/SigPep-
PRO-proteoform-std: EXACT:UniProtKB:P01137, 30-390
  Definition"A transforming growth factor beta-1 (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390." [PRO:DNx, Reactome:R-HSA-114705] 
  PRO Categoryorganism-modification 
  ParentPR:000018291 TGF-beta 1, signal peptide removed form
PR:P01137 transforming growth factor beta-1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 18                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-modification


PR:000049430 transforming growth factor beta-1, signal peptide removed form (human)
hTGFB1/SigPep-

organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human)
hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human)
hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human)
hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human)
hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human)
hTGFB1/var:R218H/Clv:2
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000619 hTGFB1/var:T81H/Clv:1
UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979		 located_inSO:0001558 polypeptide_localization_variant PMID:12493741
PR:000000620 hTGFB1/var:T81H/Clv:2
UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979		 located_inGO:0005615 extracellular space PMID:12493741
PR:000000621 hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463; PMID:12493741; PMID:12843182
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000622 hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000623 hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
GO:0043066 negative regulation of apoptotic process PMID:12493741
enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741
located_inGO:0005615 extracellular space PMID:12493741
PR:000000624 hTGFB1/var:H222D/Clv:2
UniProtKB:P01137, 30-278, His-222, CHEBI:29958		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000000625 hTGFB1/var:C225R/Clv:1
UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952		 enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000626 hTGFB1/var:C225R/Clv:2
UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000627 hTGFB1/var:R218H/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278244
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11278244
located_inGO:0005615 extracellular space PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000026335 hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:2677679; PMID:3162913
GO:0042803 protein homodimerization activity PMID:3162913
located_inGO:0031012 extracellular matrix PMID:17015622; PMID:8294500
GO:0032991 protein-containing complex PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160		 located_inGO:0032991 protein-containing complex PMID:17015622; PMID:3162913