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Protein Ontology report - IgG4 immunoglobulin complex (human)
PR:000050308 -
http://purl.obolibrary.org/obo/PR_000050308
Protein Forms
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000050308
PRO name
IgG4 immunoglobulin complex (human)
Synonyms
PRO-Short-label
:
EXACT:
hIgG4
Other
:
EXACT:
IgG4 (human)
NARROW:
IgG4 antibody (human)
Definition
"An IgG immunoglobulin complex in human that is composed of two immunoglobulin heavy chains of an IgG4 isotype and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG4 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add,
PMID:19222496
,
PMID:25368619
, PRO:ADD]
Comment
Requested by=HIPC. Requested by=CL. Note: An IgG4 immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
PRO Category
organism-complex
Parent
G0071735
IgG immunoglobulin complex
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Complex
0
Organism-Complex
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-complex
PR:000050308
IgG4 immunoglobulin complex (human)
hIgG4
"An IgG immunoglobulin complex in human that is composed of two immunoglobulin heavy chains of an IgG4 isotype and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG4 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add, PMID:19222496, PMID:25368619, PRO:ADD]
organism-complex
PR:000050312
IgG4 immunoglobulin complex, circulating (human)
hIgG4/circulating
"An IgG4 immunoglobulin complex (human) that is composed of two immunoglobulin heavy chains of an IgG4 isotype of the secretory isoform and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add, PMID:25368619, PRO:ADD]
organism-complex
PR:000050316
IgG4 B cell receptor complex (human)
hIgG4/B-cell-receptor
"An IgG4 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG4 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]
