back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - Toll-like receptor 4 (human)
PR:O00206 - http://purl.obolibrary.org/obo/PR_O00206
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:O00206   
  PRO nameToll-like receptor 4 (human) 
  Synonyms
PRO-Short-label: EXACT:hTLR4
Gene-based: RELATED:TLR4
Other: EXACT:CD284 (human) | hToll
  Definition"A Toll-like receptor 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00206] 
  PRO Categoryorganism-gene 
  ParentPR:000001155 Toll-like receptor 4
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11850 TLR4 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
UniProtKB:O00206
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:O00206
Toll-like receptor 4 (human)
hTLR4
"A Toll-like receptor 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00206]

organism-sequence


PR:O00206-1
Toll-like receptor 4 isoform 1 (human)
hTLR4/iso:1
"A Toll-like receptor 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036075
Toll-like receptor 4 isoform 1, signal peptide removed form (human)
hTLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-sequence


PR:O00206-2
Toll-like receptor 4 isoform 2 (human)
hTLR4/iso:2
"A Toll-like receptor 4 isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:O00206-3
Toll-like receptor 4 isoform h3 (human)
hTLR4/iso:h3
"A Toll-like receptor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00206-3." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000074467
Toll-like receptor 4 deaminated 1 (human)
hTLR4/Deam:1
"A Toll-like receptor 4 (human) that has been deaminated on the residue at the position equivalent to Gln-523 of the amino acid sequence represented by UniProtKB:O00206-1. Example: UniProtKB:O00206-1, Gln-523, MOD:00685." [IEDB_epitope:1353391, PRO:DNx]

organism-modification


PR:000079302
Toll-like receptor 4 deaminated 2 (human)
hTLR4/Deam:2
"A Toll-like receptor 4 (human) that has been deaminated on the residue at the position equivalent to Asn-409 of the amino acid sequence represented by UniProtKB:O00206-1. Example: UniProtKB:O00206-1, Asn-409, MOD:00684." [IEDB_epitope:2000330, PRO:DNx]

Back to top
hTLR4 forms found in complexes   

hTLR4 Component
 Complexes
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:000028678 ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036004 LY96:TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000044684 activated TLR4 complex (human)