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Protein Ontology report - left-right determination factor 2 (human)
PR:O00292 - http://purl.obolibrary.org/obo/PR_O00292
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O00292   
  PRO nameleft-right determination factor 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hLEFTY2
Gene-based: RELATED:EBAF | LEFTA | LEFTY2 | LEFTYA | PSEC0024 | TGFB4
Other: EXACT:endometrial bleeding-associated factor (human) | left-right determination factor A (human) | protein lefty-2 (human) | protein lefty-A (human) | TGF-beta-4 (human) | transforming growth factor beta-4 (human)
  Definition"A lefty 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00292
  PRO Categoryorganism-gene 
  ParentPR:000000288 lefty 2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:3122 LEFTY2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O00292
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:O00292

left-right determination factor 2 (human)

hLEFTY2


"A lefty 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00292]


organism-sequence



PR:000000452

lefty 2 sequence variant S342N (human)

hLEFTY2/var:S342N


"A left-right determination factor 2 (human) that has an Asn residue at the position equivalent to Ser-342 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347." [PMID:10053005, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O00292-1

left-right determination factor 2 isoform 1 (human)

hLEFTY2/iso:1


"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036549

lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036550

lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

organism-sequence



PR:O00292-2

left-right determination factor 2 isoform h2 (human)

hLEFTY2/iso:h2


"A left-right determination factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-2." [PRO:DNx, UniProtKB:O00292]


organism-modification



PR:000048185

left-right determination factor 2, signal peptide removed form (human)

hLEFTY2/SigPep-


"A left-right determination factor 2 (human) that has had the signal peptide removed. UniProtKB:O00292, 22-366." [PRO:DNx, Reactome:R-HSA-114708]


organism-modification



PR:000083292

left-right determination factor 2 phosphorylated 1 (human)

hLEFTY2/Phos:1


"A left-right determination factor 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-213 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-213, MOD:00046." [IEDB_epitope:2149881, PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0007275 multicellular organism developmentPR:000036549 hLEFTY2/iso:1/Clv:1 PMID:10053005
PR:O00292-1 hLEFTY2/iso:1 PMID:10053005
GO:0007309 oocyte axis specificationPR:000036549 hLEFTY2/iso:1/Clv:1 PMID:10053005
PR:O00292-1 hLEFTY2/iso:1 PMID:10053005
GO:0043406 positive regulation of MAP kinase activityPR:000036550 hLEFTY2/iso:1/Clv:2 PMID:11278322

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:0050545 visceral heterotaxyPR:000000452 hLEFTY2/var:S342N PMID:10053005

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000036549 hLEFTY2/iso:1/Clv:1 PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2 PMID:11278322