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Protein Ontology report - left-right determination factor 2 (human)
PR:O00292 - http://purl.obolibrary.org/obo/PR_O00292
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O00292   
  PRO nameleft-right determination factor 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hLEFTY2
Gene-based: RELATED:EBAF | LEFTA | LEFTY2 | LEFTYA | PSEC0024 | TGFB4
Other: EXACT:endometrial bleeding-associated factor (human) | left-right determination factor A (human) | protein lefty-2 (human) | protein lefty-A (human) | TGF-beta-4 (human) | transforming growth factor beta-4 (human)
  Definition"A lefty 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00292] 
  PRO Categoryorganism-gene 
  ParentPR:000000288 lefty 2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:3122 LEFTY2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O00292
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:O00292 left-right determination factor 2 (human)
hLEFTY2

organism-sequence


PR:000000452 lefty 2 sequence variant S342N (human)
hLEFTY2/var:S342N
Yes
organism-sequence


PR:O00292-1 left-right determination factor 2 isoform 1 (human)
hLEFTY2/iso:1
Yes
organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human)
hLEFTY2/iso:1/Clv:1
Yes
organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human)
hLEFTY2/iso:1/Clv:2
Yes
organism-sequence


PR:O00292-2 left-right determination factor 2 isoform h2 (human)
hLEFTY2/iso:h2

organism-modification


PR:000048185 left-right determination factor 2, signal peptide removed form (human)
hLEFTY2/SigPep-

organism-modification


PR:000083292 left-right determination factor 2 phosphorylated 1 (human)
hLEFTY2/Phos:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007275 multicellular organism developmentPR:000036549 hLEFTY2/iso:1/Clv:1 PMID:10053005
PR:O00292-1 hLEFTY2/iso:1 PMID:10053005
GO:0007309 oocyte axis specificationPR:000036549 hLEFTY2/iso:1/Clv:1 PMID:10053005
PR:O00292-1 hLEFTY2/iso:1 PMID:10053005
GO:0043406 positive regulation of MAP kinase activityPR:000036550 hLEFTY2/iso:1/Clv:2 PMID:11278322

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050545 visceral heterotaxyPR:000000452 hLEFTY2/var:S342N PMID:10053005

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036549 hLEFTY2/iso:1/Clv:1 PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2 PMID:11278322