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Protein Ontology report - protein Mdm4 (human)
PR:O15151 - http://purl.obolibrary.org/obo/PR_O15151
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:O15151   
  PRO nameprotein Mdm4 (human) 
  Synonyms
PRO-Short-label: EXACT:hMDM4
Gene-based: RELATED:MDM4 | MDMX
Other: EXACT:double minute 4 protein (human) | Mdm2-like p53-binding protein (human) | p53-binding protein Mdm4 (human) | protein Mdmx (human)
  Definition"A protein Mdm4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15151
  PRO Categoryorganism-gene 
  ParentPR:000010268 protein Mdm4
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6974 MDM4 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O15151
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:O15151

protein Mdm4 (human)

hMDM4


"A protein Mdm4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15151]


organism-sequence



PR:O15151-1

protein Mdm4 isoform 1 (human)

hMDM4/iso:1


"A protein Mdm4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025837

protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)

hMDM4/iso:1/PhosUbiq:1


"A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:JAN]

Yes

organism-sequence



PR:O15151-2

protein Mdm4 isoform 2 (human)

hMDM4/iso:2


"A protein Mdm4 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:O15151-3

protein Mdm4 isoform h3 (human)

hMDM4/iso:h3


"A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-3." [PRO:DNx, UniProtKB:O15151]


organism-sequence



PR:O15151-4

protein Mdm4 isoform hHDMX211 (human)

hMDM4/iso:hHDMX211


"A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-4." [PRO:DNx, UniProtKB:O15151]


organism-sequence



PR:O15151-5

protein Mdm4 isoform h5 (human)

hMDM4/iso:h5


"A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-5." [PRO:DNx, UniProtKB:O15151]


organism-modification



PR:000045578

protein Mdm4 phosphorylated 1 (human)

hMDM4/Phos:1


"A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-96 of the amino acid sequence represented by UniProtKB:O15151-1. Example: UniProtKB:O15151-1, Ser-96, MOD:00046." [iPTMnet:O15151, PMID:15735705]


organism-modification



PR:000048361

protein Mdm4 phosphorylated 2 (human)

hMDM4/Phos:2


"A protein Mdm4 (human) that has been post-translationally modified to include phosphoserine at positions 342, 367 and 403 of the amino acid sequence represented by UniProtKB:O15151. UniProtKB:O15151, Ser-342/Ser-367/Ser-403, MOD:00046." [PRO:DNx, Reactome:R-HSA-349441]


organism-modification



PR:000048362

protein Mdm4 phosphorylated 3 (human)

hMDM4/Phos:3


"A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-403 of the amino acid sequence represented by UniProtKB:O15151. UniProtKB:O15151, Ser-403, MOD:00046." [PRO:DNx, Reactome:R-HSA-349461]


organism-modification



PR:000048363

protein Mdm4 ubiquitinated form (human)

hMDM4/UbiqLys+


"A protein Mdm4 (human) that includes at least one ubiquitinated lysine. UniProtKB:O15151, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782502]


organism-modification



PR:000025837

protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)

hMDM4/iso:1/PhosUbiq:1


"A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:JAN]

Yes

organism-modification



PR:000064855

protein Mdm4 phosphorylated and ubiquitinated 1 (human)

hMDM4/PhosUbiq:1


"A protein Mdm4 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-342, Ser-367, and Ser-403 of the amino acid sequence represented by UniProtKB:O15151-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:O15151-1, Ser-342/Ser-367/Ser-403, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-6804938]


organism-modification



PR:000075564

protein Mdm4 methylated 1 (human)

hMDM4/Me:1


"A protein Mdm4 (human) that has been methylated on the residue at the position equivalent to Cys-389 of the amino acid sequence represented by UniProtKB:O15151-1. Example: UniProtKB:O15151-1, Cys-389, MOD:00660." [IEDB_epitope:1029137, PRO:DNx]


organism-modification



PR:000084138

protein Mdm4 phosphorylated 4 (human)

hMDM4/Phos:4


"A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Thr-119 of the amino acid sequence represented by UniProtKB:O15151-1. Example: UniProtKB:O15151-1, Thr-119, MOD:00047." [IEDB_epitope:2149899, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025837 hMDM4/iso:1/PhosUbiq:1
UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148
acts_upstream_of_or_withinGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator PMID:16511560
enablesGO:0071889 14-3-3 protein binding with PR:P27348 14-3-3 protein T-cell (human) PMID:16511572
GO:0071889 14-3-3 protein binding with PR:P61981 hYWHAG PMID:16511572
located_inGO:0005634 nucleus PMID:16511560