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Protein Ontology report - mitotic checkpoint protein BUB3 (human)
PR:O43684 - http://purl.obolibrary.org/obo/PR_O43684
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O43684   
  PRO namemitotic checkpoint protein BUB3 (human) 
  Synonyms
PRO-Short-label: EXACT:hBUB3
Gene-based: RELATED:BUB3
  Definition"A mitotic checkpoint protein BUB3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43684
  PRO Categoryorganism-gene 
  ParentPR:000004856 mitotic checkpoint protein BUB3
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1151 BUB3 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 16                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O43684
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:O43684

mitotic checkpoint protein BUB3 (human)

hBUB3


"A mitotic checkpoint protein BUB3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43684]

Yes

Yes
organism-sequence



PR:O43684-1

mitotic checkpoint protein BUB3 isoform h1 (human)

hBUB3/iso:h1


"A mitotic checkpoint protein BUB3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43684-1." [PRO:DNx, UniProtKB:O43684]


organism-sequence



PR:O43684-2

mitotic checkpoint protein BUB3 isoform 2 (human)

hBUB3/iso:2


"A mitotic checkpoint protein BUB3 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000035437

mitotic checkpoint protein BUB3 phosphorylated 1 (human)

hBUB3/Phos:1


"A mitotic checkpoint protein BUB3 phosphorylated 1 in human. Phosphorylated on the Ser residue within the motif D[YG]ISx[IV]K. UniProtKB:O43684, Ser-18, MOD:00046." [PMID:20057499, PRO:DAN, PRO:KER]

Yes

organism-modification



PR:000035454

mitotic checkpoint protein BUB3 unphosphorylated form (human)

hBUB3/PhosRes-


"A mitotic checkpoint protein BUB3 unphosphorylated form in human." [PRO:KER]


organism-modification



PR:000045593

mitotic checkpoint protein BUB3 phosphorylated 2 (human)

hBUB3/Phos:2


"A mitotic checkpoint protein BUB3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-207 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Tyr-207, MOD:00048." [iPTMnet:O43684, PMID:24316223]


organism-modification



PR:000071531

mitotic checkpoint protein BUB3 methylated 1 (human)

hBUB3/Me:1


"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Cys-101 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-101, MOD:00660." [IEDB_epitope:1054024, PRO:DNx]


organism-modification



PR:000071980

mitotic checkpoint protein BUB3 cysteinylated 1 (human)

hBUB3/Cyst:1


"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-184 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-184, MOD:00765." [IEDB_epitope:637078, PRO:DNx]


organism-modification



PR:000072028

mitotic checkpoint protein BUB3 cysteinylated 2 (human)

hBUB3/Cyst:2


"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-62 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-62, MOD:00765." [IEDB_epitope:924870, PRO:DNx]


organism-modification



PR:000072190

mitotic checkpoint protein BUB3 methylated 2 (human)

hBUB3/Me:2


"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Cys-105 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-105, MOD:00660." [IEDB_epitope:1057223, IEDB_epitope:1057225, PRO:DNx]


organism-modification



PR:000072404

mitotic checkpoint protein BUB3 acetylated 1 (human)

hBUB3/Ac:1


"A mitotic checkpoint protein BUB3 (human) that has been acetylated on the residue at the position equivalent to Lys-8 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Lys-8, MOD:00723." [IEDB_epitope:1832182, PRO:DNx]


organism-modification



PR:000073832

mitotic checkpoint protein BUB3 methylated 3 (human)

hBUB3/Me:3


"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Phe-284 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Phe-284, MOD:00717." [IEDB_epitope:1324242, PRO:DNx]


organism-modification



PR:000074693

mitotic checkpoint protein BUB3 cysteinylated 3 (human)

hBUB3/Cyst:3


"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-105 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-105, MOD:00765." [IEDB_epitope:1057224, IEDB_epitope:1060796, PRO:DNx]


organism-modification



PR:000079964

mitotic checkpoint protein BUB3 deaminated 1 (human)

hBUB3/Deam:1


"A mitotic checkpoint protein BUB3 (human) that has been deaminated on the residue at the position equivalent to Gln-28 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Gln-28, MOD:00685." [IEDB_epitope:2140672, PRO:DNx]


organism-modification



PR:000083767

mitotic checkpoint protein BUB3 hydroxylated 1 (human)

hBUB3/Hy:1


"A mitotic checkpoint protein BUB3 (human) that has been hydroxylated on the residue at the position equivalent to Trp-71 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Trp-71, MOD:01622." [IEDB_epitope:1317184, PRO:DNx]


organism-modification



PR:000083783

mitotic checkpoint protein BUB3 methylated 4 (human)

hBUB3/Me:4


"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Cys-129 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-129, MOD:00660." [IEDB_epitope:1025305, PRO:DNx]


organism-modification



PR:000083859

mitotic checkpoint protein BUB3 deaminated 2 (human)

hBUB3/Deam:2


"A mitotic checkpoint protein BUB3 (human) that has been deaminated on the residue at the position equivalent to Gln-118 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Gln-118, MOD:00685." [IEDB_epitope:760621, PRO:DNx]


organism-modification



PR:000084196

mitotic checkpoint protein BUB3 deaminated 3 (human)

hBUB3/Deam:3


"A mitotic checkpoint protein BUB3 (human) that has been deaminated on the residue at the position equivalent to Asn-247 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Asn-247, MOD:00684." [IEDB_epitope:764763, PRO:DNx]


organism-modification



PR:000085371

mitotic checkpoint protein BUB3 cysteinylated 4 (human)

hBUB3/Cyst:4


"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-129 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-129, MOD:00765." [IEDB_epitope:927829, PRO:DNx]


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hBUB3 forms found in complexes   

hBUB3 Component
Complexes
PR:O43684 hBUB3 PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:000035563 BUB1B:BUB3 complex (human)
PR:000035564 BUB1:BUB3 complex (human)
PR:000035567 BUB1:BUB3:MAD1L1 complex (human)
PR:000035576 BUB1:BUB3:APC complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035437 hBUB3/Phos:1
UniProtKB:O43684, Ser-18, MOD:00046
acts_upstream_of_or_withinincreased GO:0012501 programmed cell death relative to PR:000035454 hBUB3/PhosRes- PMID:20057499
PR:O43684 hBUB3 enablesGO:0005515 protein binding with PR:O15350-1 PMID:10198256
GO:0005515 protein binding with PR:O15350-2 PMID:10198256
GO:0005515 protein binding with PR:O15350-3 PMID:10198256
GO:0005515 protein binding with PR:O15350-5 PMID:10198256
GO:0005515 protein binding with PR:O43683 BUB1 PMID:10198256
GO:0005515 protein binding with PR:O60566 BUB1B PMID:10198256
GO:0005515 protein binding with PR:P25054 APC PMID:10198256
GO:0005515 protein binding with PR:Q12834 CDC20 PMID:10198256
GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:10198256
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 PMID:10198256
located_inGO:0000776 kinetochore PMID:11283619