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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)

PR:O60566 - http://purl.obolibrary.org/obo/PR_O60566

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

PAF

GPI

PRO ID

PR:O60566

PRO name

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)

Synonyms

PRO-Short-label:	EXACT:	hBUB1B
Gene-based:	RELATED:	BUB1B \| BUBR1 \| MAD3L \| SSK1
Other:	EXACT:	hBUBR1 \| MAD3/BUB1-related protein kinase (human) \| mitotic checkpoint kinase MAD3L (human) \| protein SSK1 (human)

Definition

"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60566]

PRO Category

organism-gene

Parent

PR:000004855 mitotic checkpoint serine/threonine-protein kinase BUB1 beta
PR:000029067 Homo sapiens protein

Gene Template

HGNC:1149 BUB1B (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	3
Modification	0	Organism-Modification	16

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	UniProtKB:O60566

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

organism-gene

PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)

hBUB1B

Yes

organism-sequence

PR:O60566-1 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human)

hBUB1B/iso:1

organism-modification

PR:000028798 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human)

hBUB1B/iso:1/Ac:1

organism-sequence

PR:O60566-2 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h2 (human)

hBUB1B/iso:h2

organism-sequence

PR:O60566-3 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h3 (human)

hBUB1B/iso:h3

organism-modification

PR:000035362 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human)

hBUB1B/Phos:1

Yes

organism-modification

PR:000035373 mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human)

hBUB1B/PhosRes-

Yes

organism-modification

PR:000035428 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)

hBUB1B/Phos:2

Yes

organism-modification

PR:000035432 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)

hBUB1B/Phos:3

Yes

organism-modification

PR:000035435 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human)

hBUB1B/Phos:4

Yes

organism-modification

PR:000065892 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 1 (human)

hBUB1B/Me:1

organism-modification

PR:000066223 mitotic checkpoint serine/threonine-protein kinase BUB1 beta cysteinylated 1 (human)

hBUB1B/Cyst:1

organism-modification

PR:000070779 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 1 (human)

hBUB1B/Deam:1

organism-modification

PR:000074218 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 2 (human)

hBUB1B/Deam:2

organism-modification

PR:000074309 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 2 (human)

hBUB1B/Me:2

organism-modification

PR:000076756 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 3 (human)

hBUB1B/Me:3

organism-modification

PR:000077474 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 4 (human)

hBUB1B/Me:4

organism-modification

PR:000077494 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 3 (human)

hBUB1B/Deam:3

organism-modification

PR:000078944 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 5 (human)

hBUB1B/Me:5

organism-modification

PR:000080893 mitotic checkpoint serine/threonine-protein kinase BUB1 beta citrullinated 1 (human)

hBUB1B/Cit:1

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hBUB1B forms found in complexes

hBUB1B Component	Complexes
PR:000035373 hBUB1B/PhosRes-	PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:000035428 hBUB1B/Phos:2	PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:O60566 hBUB1B	PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
	PR:000035563 BUB1B:BUB3 complex (human)
	PR:000035575 BUB1B:CDC20 complex (human)

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000035362 hBUB1B/Phos:1 Example: UniProtKB:O60566-1, Thr-620, MOD:00047	enables	increased GO:0005515 protein binding with PR:P53350 hPLK1	PMID:17785528
PR:000035373 hBUB1B/PhosRes-	acts_upstream_of_or_within	GO:0001933 negative regulation of protein phosphorylation	PMID:22801780
		GO:0010826 negative regulation of centrosome duplication	PMID:19503101
		GO:0033673 negative regulation of kinase activity	PMID:19503101
	enables	GO:0005515 protein binding with PR:000035669 hPLK1/PhosRes-	PMID:19503101
	located_in	GO:0000776 kinetochore	PMID:22801780
	located_in	GO:0005813 centrosome	PMID:19503101
PR:000035428 hBUB1B/Phos:2 Example: UniProtKB:O60566-1, Thr-620, MOD:00047\|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)\|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)	acts_upstream_of_or_within	GO:0006974 DNA damage response	PMID:18440313
		increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes-	PMID:17785528
		increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes-	PMID:17376779; PMID:17785528
	enables	increased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes-	PMID:17376779
		increased GO:0005515 protein binding with PR:O43683 BUB1	PMID:23079597
		increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A	PMID:23079597
		increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes-	PMID:23079597
	located_in	GO:0000776 kinetochore	PMID:17785528
PR:000035432 hBUB1B/Phos:3 Example: UniProtKB:O60566-1, Thr-608, MOD:00047	acts_upstream_of_or_within	decreased GO:0001933 negative regulation of protein phosphorylation relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
		increased GO:0007059 chromosome segregation relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
		increased GO:0031577 spindle checkpoint signaling relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
		increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
		increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
		increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
	located_in	GO:0000776 kinetochore	PMID:22801780
PR:000035435 hBUB1B/Phos:4 Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046	acts_upstream_of_or_within	increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035373 hBUB1B/PhosRes-	PMID:19015317; PMID:20016069
	acts_upstream_of_or_within	increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes-	PMID:20016069
	located_in	GO:0000776 kinetochore	PMID:19015317
PR:O60566 hBUB1B	acts_upstream_of_or_within	GO:0006469 negative regulation of protein kinase activity	PMID:15592459
		GO:0031577 spindle checkpoint signaling	PMID:11030144
		GO:0031647 regulation of protein stability	PMID:17671183
		NOT GO:0034501 protein localization to kinetochore	PMID:16760428
		GO:0051310 metaphase chromosome alignment	PMID:12719470; PMID:15592459
		GO:0051444 negative regulation of ubiquitin-protein transferase activity	PMID:15525512
		GO:0051444 negative regulation of ubiquitin-protein transferase activity	PMID:15525512
		GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore	PMID:15592459
	enables	GO:0005515 protein binding with PR:000035449 hCDC27/Phos:1	BioGRID:BG-682429
		GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes-	BioGRID:BG-682429
		GO:0005515 protein binding with PR:O15350 hTP73	BioGRID:BG-682429
		GO:0005515 protein binding with PR:O15379 HD3 (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:O43683 BUB1	BioGRID:BG-682429
		GO:0005515 protein binding with PR:O43684 BUB3	BioGRID:BG-682429
		GO:0005515 protein binding with PR:O76070 BCSG1	BioGRID:BG-682429
		GO:0005515 protein binding with PR:O95997 EAP1	BioGRID:BG-682429
		GO:0005515 protein binding with PR:P04049 cRaf (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:P04637-1	BioGRID:BG-682429
		GO:0005515 protein binding with PR:P09874 ADP-ribosyltransferase diphtheria toxin-like 1 (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:P25054 APC	BioGRID:BG-682429
		GO:0005515 protein binding with PR:P51587 BRCA2	BioGRID:BG-682429
		GO:0005515 protein binding with PR:P63010 adaptor protein complex AP-2 subunit beta (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q02224 CENP-E (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q12834 CDC20	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q13042 ANAPC6	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q13257 hMAD2L1	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q13547 HD1 (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q15013 caught by MAD2 protein (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q92769 HD2 (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q92831 histone acetylase PCAF (human)	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q96GD4 AIK2	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q96IF1 AJUBA	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q9H081 hMIS12	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q9H4B4 CNK	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q9NQS7 hINCENP	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q9UJX3 ANAPC7	BioGRID:BG-682429
		GO:0005515 protein binding with PR:Q9UJX5 ANAPC4	BioGRID:BG-682429
		GO:0016301 kinase activity	PMID:11030144
		GO:0055105 ubiquitin-protein transferase inhibitor activity	PMID:15525512
		GO:0055105 ubiquitin-protein transferase inhibitor activity	PMID:15525512
	located_in	GO:0000776 kinetochore	PMID:12719470; PMID:16760428
		GO:0000922 spindle pole	PMID:15190214
		GO:0000939 inner kinetochore	PMID:11792804
		GO:0000940 outer kinetochore	PMID:11792804
		GO:0005737 cytoplasm	PMID:10749118