Protein Ontology

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Protein Ontology report - Myc proto-oncogene protein (human)

PR:P01106 - http://purl.obolibrary.org/obo/PR_P01106

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Ontology Information

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PRO ID

PR:P01106

PRO name

Myc proto-oncogene protein (human)

Synonyms

PRO-Short-label:	EXACT:	hMYC
Gene-based:	RELATED:	BHLHE39 \| MYC
Other:	EXACT:	class E basic helix-loop-helix protein 39 (human) \| proto-oncogene c-Myc (human) \| transcription factor p64 (human)

Definition

"A c-myc protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01106]

PRO Category

organism-gene

Parent

PR:000000084 c-myc protein
PR:000029067 Homo sapiens protein

Gene Template

HGNC:7553 MYC (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	3
Modification	0	Organism-Modification	9

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	UniProtKB:P01106

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

organism-gene

PR:P01106 Myc proto-oncogene protein (human)

hMYC

organism-sequence

PR:P01106-1 c-myc protein isoform 1 (human)

hMYC/iso:1

organism-modification

PR:000026033 c-myc protein isoform 1 acetylated 1 (human)

hMYC/iso:1/Ac:1

organism-modification

PR:000026038 c-myc protein isoform 1 unmodified form (human)

hMYC/iso:1/UnMod

organism-modification

PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human)

hMYC/iso:1/Phos:4

organism-modification

PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human)

hMYC/iso:1/OGlyco:1

organism-modification

PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human)

hMYC/iso:1/Phos:2

organism-modification

PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human)

hMYC/iso:1/Phos:3

organism-modification

PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human)

hMYC/iso:1/Phos:1

organism-sequence

PR:P01106-2 c-myc protein isoform 2 (human)

hMYC/iso:2

organism-sequence

PR:P01106-3 Myc proto-oncogene protein isoform h3 (human)

hMYC/iso:h3

organism-modification

PR:000048491 Myc proto-oncogene protein ubiquitinated form (human)

hMYC/UbiqLys+

organism-modification

PR:000077803 Myc proto-oncogene protein deaminated 1 (human)

hMYC/Deam:1

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hMYC forms found in complexes

hMYC Component	Complexes
PR:000026033 hMYC/iso:1/Ac:1	PR:000026035 Myc-max acetylated complex (human)
PR:000026038 hMYC/iso:1/UnMod	PR:000026039 Myc-max complex 1 (human)
PR:P01106 hMYC	PR:000025987 Myc-max complex (human)

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000026033 hMYC/iso:1/Ac:1 UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394	enables	GO:0003700 DNA-binding transcription factor activity	PMID:16126174
	located_in	GO:0005634 nucleus	PMID:16126174
	located_in	GO:0005667 transcription factor complex	PMID:16126174
PR:000026051 hMYC/iso:1/OGlyco:1 UniProtKB:P01106-1, Thr-58, MOD:00806	acts_upstream_of_or_within	GO:0006357 regulation of transcription by RNA polymerase II	PMID:11904304
	enables	GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:11904304
PR:000026054 hMYC/iso:1/Phos:2 UniProtKB:P01106-1, Thr-58, MOD:00047\|Ser-62, MOD:00046	enables	NOT GO:0003700 DNA-binding transcription factor activity	PMID:7623799
PR:000026055 hMYC/iso:1/Phos:3 UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046	acts_upstream_of_or_within	GO:0045766 positive regulation of angiogenesis	PMID:12676581
	located_in	GO:0005634 nucleus	PMID:12676581
PR:000036448 hMYC/iso:1/Phos:1 UniProtKB:P01106-1, Ser-62, MOD:00046	enables	GO:0005515 protein binding with PR:O15169-1	PMID:19131971
PR:P01106-1 hMYC/iso:1	acts_upstream_of_or_within	GO:0006357 regulation of transcription by RNA polymerase II	PMID:16908182; PMID:2006410
		GO:0008283 cell population proliferation	PMID:10962037
		GO:0051726 regulation of cell cycle	PMID:10962037
	enables	contributes_to GO:0003700 DNA-binding transcription factor activity	PMID:16908182; PMID:2006410
	enables	GO:0005515 protein binding	PMID:12706874
	located_in	GO:0005667 transcription factor complex	PMID:16908182; PMID:2006410
PR:P01106-2 hMYC/iso:2	enables	contributes_to GO:0003700 DNA-binding transcription factor activity	PMID:3277717