PRO Term |
GO Annotation |
Evidence |
PR:000000398 hTGFB1/var:L10P UniProtKB:P01137, Leu-10, CHEBI:50342 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:9783545 |
PR:000000399 hTGFB1/var:T81H UniProtKB:P01137, Tyr-81, CHEBI:29979 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11062463 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
located_in | SO:0001558 polypeptide_localization_variant |
PMID:11062463; PMID:12493741 |
PR:000000400 hTGFB1/var:R218C UniProtKB:P01137, Arg-218, CHEBI:29950 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:12843182 |
GO:0043066 negative regulation of apoptotic process |
PMID:11062463; PMID:12493741; PMID:12843182 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:10973241; PMID:11062463; PMID:12493741; PMID:12843182 |
enables | increased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000401 hTGFB1/var:R218H UniProtKB:P01137, Arg-218, CHEBI:29979 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
PR:000000402 hTGFB1/var:H222D UniProtKB:P01137, His-222, CHEBI:29958 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:12493741 |
GO:0043066 negative regulation of apoptotic process |
PMID:12493741 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
PR:000000403 hTGFB1/var:C225R UniProtKB:P01137, Cys-225, CHEBI:29952 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11062463; PMID:12493741; PMID:12843182 |
GO:0043066 negative regulation of apoptotic process |
PMID:11062463; PMID:12493741; PMID:12843182 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
enables | increased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod |
PMID:11062463; PMID:12493741; PMID:12843182 |
located_in | GO:0005615 extracellular space |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000619 hTGFB1/var:T81H/Clv:1 UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979 |
located_in | SO:0001558 polypeptide_localization_variant |
PMID:12493741 |
PR:000000620 hTGFB1/var:T81H/Clv:2 UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979 |
located_in | GO:0005615 extracellular space |
PMID:12493741 |
PR:000000621 hTGFB1/var:R218C/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11062463; PMID:12493741; PMID:12843182 |
enables | GO:0005160 transforming growth factor beta receptor binding |
PMID:11278244 |
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:11062463; PMID:12493741; PMID:12843182 |
GO:0042803 protein homodimerization activity |
PMID:11062463; PMID:12493741; PMID:12843182 |
located_in | GO:0005615 extracellular space |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000622 hTGFB1/var:R218C/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
PR:000000623 hTGFB1/var:H222D/Clv:1 UniProtKB:P01137, 279-390, His-222, CHEBI:29958 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:12493741 |
GO:0043066 negative regulation of apoptotic process |
PMID:12493741 |
enables | increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:12493741 |
located_in | GO:0005615 extracellular space |
PMID:12493741 |
PR:000000624 hTGFB1/var:H222D/Clv:2 UniProtKB:P01137, 30-278, His-222, CHEBI:29958 |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
SO:0001601 conformational_change_variant |
PMID:11278244 |
PR:000000625 hTGFB1/var:C225R/Clv:1 UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 |
enables | increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:11062463; PMID:12493741; PMID:12843182 |
located_in | GO:0005615 extracellular space |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000626 hTGFB1/var:C225R/Clv:2 UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
PR:000000627 hTGFB1/var:R218H/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11278244 |
enables | GO:0005160 transforming growth factor beta receptor binding |
PMID:11278244 |
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:12493741; PMID:12843182 |
GO:0042803 protein homodimerization activity |
PMID:11278244 |
located_in | GO:0005615 extracellular space |
PMID:11278244 |
PR:000000628 hTGFB1/var:R218H/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
SO:0001601 conformational_change_variant |
PMID:11278244 |
PR:000025927 hTGFB1/iso:1/mature UniProtKB:P01137-1, 279-390 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:8471846 |
GO:0043066 negative regulation of apoptotic process |
PMID:9918798 |
enables | GO:0042803 protein homodimerization activity |
PMID:3162913; PMID:8471846 |
located_in | GO:0031012 extracellular matrix |
PMID:8294500 |
PR:000026335 hTGFB1/iso:1/inactive UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:3162913 |
enables | NOT GO:0005160 transforming growth factor beta receptor binding |
PMID:2677679; PMID:3162913 |
GO:0042803 protein homodimerization activity |
PMID:3162913 |
located_in | GO:0031012 extracellular matrix |
PMID:17015622; PMID:8294500 |
GO:0032991 protein-containing complex |
PMID:3162913 |
PR:000036526 hTGFB1/iso:1/LAP UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160 |
located_in | GO:0032991 protein-containing complex |
PMID:17015622; PMID:3162913 |
PR:P01137-1 hTGFB1/iso:1 |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:1544940 |
GO:0043066 negative regulation of apoptotic process |
PMID:9918798 |
enables | GO:0042803 protein homodimerization activity |
PMID:1544940 |
located_in | GO:0005796 Golgi lumen |
PMID:1544940 |